Posted by PeterJ on May 8, 2000, at 20:00:23
In reply to Re: Drugs for Creativity? , posted by Janice on May 8, 2000, at 14:37:42
> hi Dc,
>
> I forgot to respond to your part about stimulants. Of course, we are all different, but I found stimulants either prevented or decreased my mania. I'm not positive, but I believe they would more often than not prevent rather than induce mania (for me anyway). JaniceYour observation is backed up by several studies and case reports showing that amphetamine reduces manic symptoms On the other hand there are reports of amphetamine inducing mania as well and certainly the effects of amphetamine can mimic manic symptoms. It would seem that many bipolar individuals react to amphetamine in a ways similar to people with ADHD and find the stimulant calming. Here are some references.
Peter
Case study: antimanic effectiveness of dextroamphetamine in a brain-injured adolescent.
Max JE; Richards L; Hamdan-Allen G
University of Iowa, Department of Psychiatry, Iowa City 52242-1009, USA.
J Am Acad Child Adolesc Psychiatry 1995 Apr;34(4):472-6
ABSTRACT:
A relatively enduring and counterintuitive antimanic response to dextroamphetamine in a brain-injured
adolescent who had failed trials involving divalproex, lithium, haloperidol, and carbamazepine is
described. This finding combined with data from previous reports of antimanic effects of test doses of
stimulants imply that such a pharmacological probe may prove relevant for the prediction of treatment
response of mania to dextroamphetamine and perhaps for subclassification of bipolar disorder.Treatment of mania with dextroamphetamine [letter]
Clower CG
J Clin Psychiatry 1988 Jul;49(7):283Dextroamphetamine treatment of mania.
Garvey MJ; Hwang S; Teubner-Rhodes D; Zander J; Rhem C
Department of Psychiatry, Veterans Administration Medical Center, Iowa City, IA 52242.
J Clin Psychiatry 1987 Oct;48(10):412-3
ABSTRACT: Five of six acutely manic patients treated with dextroamphetamine experienced a 50% or greater
reduction in their mania severity scores. Side effects were noted in only one patient. The treatment
results suggest that dextroamphetamine might be useful in the treatment of mania.[Proceedings: D-Amphetamine in manic syndrome (author's transl)]
D-Amphetamin beim manischen Syndrom
Beckmann H; Heinemann H
Arzneimittelforschung 1976;26(6):1185-6
ABSTRACT:
Six manic patients were acutely treated with 30 or 50 mg d-amphetamine, respectively. There was no
intensification in any of these patients of gross manic behavior or single manic symptoms. Conversely,
there was sedation and considerable reduction of manic symptomatology in all of them. This effect
lasted for 1 to 3 h only. The clinical subgroup "elated-grandiose" was significantly, the subgroup
"paranoid-destructive" was not significantly influenced. "Drive" and "mood" were similarly reduced.
There was, however, no complete recovery from mania.
poster:PeterJ
thread:32741
URL: http://www.dr-bob.org/babble/20000508/msgs/32818.html