Posted by Cam W. on March 1, 2000, at 21:33:42
In reply to questions for the meds specialists around here, posted by SIGOLENE on March 1, 2000, at 15:13:52
Sigolene - Tricyclics block the serotonin (5-HT) reuptake pump just like SSRIs, but they also block norepinephrine (NE) reuptake pumps as well (also blocking cholinergic-muscarinic-M1, histamine-H1, and alpha-adrenergic receptors which is why we see so many side effects with the TCAs). They do work differently than SSRIs and one may work for you. Desipramine blocks NE reuptake more than 5-HT reuptake, but Clomipramine blocks 5-HT reuptake more than NE reuptake. Since you haven't responded to SSRIs, your doctor might be better off prescribing a TCA from the Desipramine end of the spectrum. With TCAs in general, you may notice more dry mouth and sedation than with SSRIs, but not as much sexual dysfunction (except, sometimes, with Clomipramine). Hope this helps - Cam W.
poster:Cam W.
thread:25205
URL: http://www.dr-bob.org/babble/20000220/msgs/25321.html