Posted by Cam W. on February 19, 2000, at 13:11:16
In reply to Comparing benzos - your experiences please.., posted by John on February 19, 2000, at 12:29:48
> Although the mechanisms are all similar, there are substantive differences that I invite feedback over:
>
> 1. diazepam: Has a definitive onset of action, but the effect lasts shorter than others, although because of active metabolites, there is still sedating drug flowing: e.g. have a beer after a few days of 15mg/day and though perhaps 5 or more hours after the last pill, the accumulation is definite!
>
> 2. chlordiazepoxide: As I recall less 'effect' but equally anxiolitic, and less (half) as long lingering in the system (un-noted) until some other substance activates.. And so cheap.
>
> 3. clorazepate: This is something I have little recollection of but have read of its potentially incredible accumulative properties
>
> 4. clonazepam: Seems ideal for lack of rapid (flush) onset and questionable accumulation as established by at least No. 1 above.
>
> 5. alprazolam: So popular but why?
>
> 6. lorazepam: slow onset, but rapidly out and... by FAR THE WORST 'withdrawal' of any and after very short course of therapy. What is it about this one that is so MISERABLE (in the end)
>
> 7. bromazepam seems like another ideal one as clonaz but no US.John - Just to start out, the worst withdrawl from long-term benzodiazepine use is Halcion (triazolam). All Benzodiazepines (BZDs) have different pharmacokinetics (absorption, metabolism, distribution and excretion). It is the differences between these factors that account for the differences in each BZD's activity in the body.They all do exactly the same thing to the GABA receptor. They bind to the GABA receptor and better facilitate GABA's binding (GABA now binds easier to the receptor, thus facilitating its inhibitory control over other neurons.) - Cam W.
poster:Cam W.
thread:22501
URL: http://www.dr-bob.org/babble/20000209/msgs/22507.html