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Re: Parnate vs Moclobemide in terms of Social phobia

Posted by Scott L. Schofield on January 30, 2000, at 13:29:34

In reply to Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 29, 2000, at 15:50:47

> Hi,

> I am on Parnate for about 6 weeks. It really helps with anxiety but itīs not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I donīt care about anything.

> I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.

> Thanks for any replies!


I hope you get plenty of replies. I would really like to know how successful moclobemide (Manerix) can be for social phobia.

About four years ago, the manufacturer (Roche, I believe) was conducting clinical trials in the U.S. for the indication of social phobia. Of course, they wanted to get it approved by the FDA for anything, thereby making it the first reversible MAO-inhibitor in the country. When I spoke to the drug company's director of U.S. investigations for moclobemide, he told me that they had dropped the project, but did not say why.

From some of the stuff that I've read, I think Nardil is the MAOI considered to be the best choice for treating social phobia. It is also often used in GAD (generalized anxiety disorder). I don't doubt that Parnate can be very effective too - I guess you have to try them to find out. It may seem counterintuitive that a drug known to be stimulating can reduce anxiety, but it definitely can.

As far as moclobemide is concerned, I have never thought much of it as an antidepressant - especially in severe cases. I have tried it, but my opinion is based more on what I have read than on what my personal experience had been. Likewise, the investigators whose opinions I respect a great deal don't think very much of moclobemide for social phobia either. The advantages of using moclobemide include a reduced need to follow a special diet of food-restrictions and a perhaps better side-effect profile.

Usual caveats apply. Moclobemide may work miracles for you.


- Scott


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poster:Scott L. Schofield thread:20013
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