Psycho-Babble Neurotransmitters Thread 1004444

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Desipramine, Nortriptyline, Vivactil+Parnate???

Posted by MRM1666 on December 8, 2011, at 5:15:51

Hello.

I've suffered from Major Depression my entire adult life. My primary symptom is a kind of ennervation, a tiredness that seems to be present most of the time.

Can anyone say if they have added to Parnate any of the following:

Desipramine, or Nortriptyline, or Vivactil? If so, did you feel more "energized?"

I don't want to add a stimulant (not even Nuvigil) because it becomes very easy for me to build a tolerance to such medications).

My current medications are the following:

1. Parnate-100mgs
2. Abilify-10 mgs and 3. Lamictal 200mg (both to potentiate the Parnate)and
3. Lunesta-3mgs

My current psychiatrist is wary of adding a TCA (the ones listed above) to my mix so I'm beginning to search for a different psychiatrist.

Thank you again.

 

Re: Desipramine, Nortriptyline, Vivactil+Parnate???

Posted by williamockham on December 9, 2011, at 8:45:40

In reply to Desipramine, Nortriptyline, Vivactil+Parnate???, posted by MRM1666 on December 8, 2011, at 5:15:51

Nortriptyline was sedating for me, even up to 100mg taken chronically, although not nearly as sedating as amitriptyline. Were I to add a TCA to my MAOI, would def start with desipramine. Not too familiar with protriptyline; the affinities suggest it's got more anticholinergic, antihistamine, and 5HT2A antagonism action, relative to NET inhibition, than desi. But affinities can be misleading. Maybe worth a shot, too. I'd be interested to hear about the results.

 

Desipramine, Nortriptyline, Vivactil+Parnate???

Posted by MRM1666 on December 11, 2011, at 16:03:18

In reply to Re: Desipramine, Nortriptyline, Vivactil+Parnate???, posted by williamockham on December 9, 2011, at 8:45:40

Hi williamockham, and thanks for your response.

Yes, I'll be speaking with my psychopharmacologist about adding Desipramine (or Vivactil) to the other medications I'm on, but I don't know if he'll be willing to do so.

Thanks again.


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