Psycho-Babble Neurotransmitters Thread 944066

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Nortriptyline a 5-HT2c antagonist/inverse agonist?

Posted by SLS on April 19, 2010, at 16:45:20

How potent is nortriptyline as a 5-HT2c antagonist or inverse agonist?

- Scott

What about amitriptyline + 5HT2C=)weight gain?

Posted by Brainbeard on May 25, 2010, at 6:57:00

In reply to Nortriptyline a 5-HT2c antagonist/inverse agonist?, posted by SLS on April 19, 2010, at 16:45:20

> How potent is nortriptyline as a 5-HT2c antagonist or inverse agonist?
>
>
> - Scott

Yeah, that's what I wanna know too. And the same for amitriptyline!!

Perhaps nortriptyline and amitriptyline's 5HT2C-antagonism is the main reason why they are likely to cause weight gain. I gain weight like crazy on low dose Prozac, which must also be due to 5HT2C-antagonism..

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