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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by sowhysosad on April 2, 2009, at 23:15:17
Let's say the dopamine receptors are rendered supersensitive as a side effect of an AD like fluoxetine.
If you were to add a dopaminergic supplement to the mix - NADH for example - would the receptors downregulate to adapt to the extra dopamine?
Or could this create problems by overstimulating the already overly-sensitive receptors?
I'm considering this strategy to combat EPS from fluoxetine, but I don't want to make things worse!
Posted by desolationrower on April 3, 2009, at 3:29:53
In reply to Supersensitive dopamine receptors/downregulation, posted by sowhysosad on April 2, 2009, at 23:15:17
well long-term you do want to get a reasonable stimulus to that part of the brain; part of supersensitivity may also be atrophy of the neurons. I would think you'd want to use them in complex ways, to fully utilize every bit of the pathway, and redevelop properly.
-d/r
Posted by sowhysosad on April 3, 2009, at 11:41:19
In reply to Re: Supersensitive dopamine receptors/downregulation, posted by desolationrower on April 3, 2009, at 3:29:53
I was interested to read that all SSRI's and some other AD's, including imipramine, render D2 receptors supersensitive after chronic use.
That said, another study shows that CBT alone also has this effect, so perhaps it's an adaptive mechanism of the brain when recovering from depression rather than being caused by the meds themselves.
So do you think "upping" the dopamine with supersensitive receptors should be ok d/r?
Posted by Alexanderfromdenmark on April 8, 2009, at 17:35:30
In reply to Supersensitive dopamine receptors/downregulation, posted by sowhysosad on April 2, 2009, at 23:15:17
Can you provide a link to the studies saying that CBT renders D2 receptors supersensitive?
Posted by sowhysosad on April 9, 2009, at 17:59:58
In reply to Re: Supersensitive dopamine receptors/downregulation, posted by Alexanderfromdenmark on April 8, 2009, at 17:35:30
> Can you provide a link to the studies saying that CBT renders D2 receptors supersensitive?
This will be the study I was thinking of:
http://www3.interscience.wiley.com/journal/120123080/abstract
Whilst it doesn't say they're rendered SUPERsensitive, it does suggest that D2 sensitivity increases after long-term CBT.
This is the end of the thread.
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