![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by PamS on May 12, 2008, at 19:33:50
Hi all,
I have a bottle of bulk inositol powder here that I've been wanting to try for my panic/anxiety, but have been nervous due to the high amounts that they recommend (approximately 12 grams). I've tried 1/4 teaspoon mixed in water, but that is only 750 mgs and I felt no change, obviously.
I was wondering if anyone knew exactly what part of the brain inositol triggers. Is it the serotonin receptors, GABA or both? I've heard that it inhibits desensitization of serotonin receptors, thereby, making them work better, and that when serotonin goes up, GABA automatically goes up. Is GABA connected to serotonin this way, or does inositol actually trigger GABA directly as well as serotonin?
Thanks in advance,
Pam
Posted by bleauberry on May 15, 2008, at 19:51:28
In reply to Inositol and Neurotransmitters, posted by PamS on May 12, 2008, at 19:33:50
I think it is a pretty fair assumption that when we cannot manipulate one neurotransmitter system without directly or indirectly impacting the others. Exactly what inositol's impact on other neuros would be I think is not understood in detail.
From what I have read, it looks like inositol is a second messenger for serotonin, whatever that means. It somehow works with the serotonin system. Some people find it calming, some people not. Some people find it antidepressant, some people not.
Starting with 750mg I think was wise. I doubt one dose, unless a big one, is going to have much impact though. A strategy to try would be to take 750mg a day for 4 days in a row and see if there is any accumulative effect. If not, then double the dose and go another 4 days. Keep going like that until something happens and you can feel what it is doing.
Posted by SLS on May 16, 2008, at 5:04:31
In reply to Re: Inositol and Neurotransmitters, posted by bleauberry on May 15, 2008, at 19:51:28
I think inositol helps to stabilize neuronal membranes and locks receptors in place as an anchor. Perhaps inositol acts more like a mood-stabilizer for bipolar disorder.
Second messengers are formed in the post-synaptic neuron in response to receptor (G-coupled) stimulation. The cascade of events subsequently modulates nuclear gene expression. This probably works as a negative-feedback system to modulate receptor sensitivity. This is where lithium comes in. I believe it is an inhibitor of protein-kinase C, which inhibits the encoding of receptor numbers in the membrane. G-proteins? I don't remember.
- Scott
Posted by PamS on May 19, 2008, at 11:11:44
In reply to Re: Inositol and Neurotransmitters, posted by bleauberry on May 15, 2008, at 19:51:28
I read that also, about inositol being a second messenger for serotonin, but never new what that meant either. Titrating the dose every four days sounds like a good plan. Thanks for the suggestion.
This is the end of the thread.
Psycho-Babble Neurotransmitters | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
[email protected]
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.