Psycho-Babble Medication Thread 1122276

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Adderall help, please!!!

Posted by Jay2112 on December 1, 2023, at 21:40:38

Well, no doubt, I am experiencing tolerance...HIGH tolerance to Adderall. I am at 25mgs, and it's like I am taking nothing. Now, I have been on it, on and off, for years, but it's never been this bad. Do I have to stop if for a few weeks....a few months??? It has been the ONLY med (so far) to REALLY help me...I mean, take away the tears, and the fears.

Thank you,
Jay

Re: Adderall help, please!!!

Posted by SLS on December 8, 2023, at 9:04:49

In reply to Adderall help, please!!!, posted by Jay2112 on December 1, 2023, at 21:40:38

> Well, no doubt, I am experiencing tolerance...HIGH tolerance to Adderall. I am at 25mgs, and it's like I am taking nothing. Now, I have been on it, on and off, for years, but it's never been this bad. Do I have to stop if for a few weeks....a few months??? It has been the ONLY med (so far) to REALLY help me...I mean, take away the tears, and the fears.
>
> Thank you,
> Jay

As you know, I have responded best to the combining of MAOI + TCA. Of those combinations, Nardil + nortriptyline is what brought me to a sweet remission.

I built up a tolerance to high dosages of amphetamine when used as monotherapy or in combination with Parnate and desipramine. However it took less than a week for it to quit on me. That's my brain's modus operendi for all of the other drugs that I initially responded to. As far as the ways each of us react to amphetamine, they might not reflect the same neurobiological diathesis (substrate).

Before antidepressants came along, amphetamine was about the only substance that could make a dent in depression. However, remission was a rare outcome. Amphetamine is a legitimate adjunct, although I don't know what drugs it works best with.

If amphetamine has quit on you, you should quit on it. If tolerance is a problem, it is likely that there is no place for amphetamine in your treatment regime.

This is my magic:

Nardil - 90 mg/day
Nortriptyline - 100 mg/day
Lamotrigine - 300 mg/day
Lithium - 600 mg/day

I was slowly getting diminishing returns when I was taking lithium 300mg/day. Moving up to 600 mg/day is recapturing the more robust remission I maintained in the beginning.

- Scott

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