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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 19 to 43 of 43. Go back in thread:
Posted by undopaminergic on November 10, 2020, at 0:11:03
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on November 9, 2020, at 12:46:25
>
> Pramipexole sure is interesting, but difficult to come by... most doctors especially in Germany are afraid of full dopamine agonists ^^
>
> Imho Aripiprazole is interesting because it is pro-dopaminergic at low dosages (2 mg) and it exhibits 5HT2-antagonist-properties AND it isn't a strong antihistamine. But yeah, your mileage may vary.
>
> Low dosage of Olanzapine is also interesting, but strong antihistamine... ^^
>
> What is your current regimen?Sulpiride 150 mg, clozapine 350 mg, cariprazine 1.5 mg, lamotrigine 200 mg, and most importantly, trimipramine 150 mg.
Clozapine is particularly useless in my experience. Sulpiride was even better than a stimulant when I first tried it, but this effect disappeared after some week or so. Cariprazine may be slightly activating, and I recommend it over aripiprazole. Lamotrigine seems to do nothing. Trimipramine is the best drug I've ever tried that is classified as an antidepressant.
-undopaminergic
Posted by Skeletor on November 10, 2020, at 19:24:02
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 10, 2020, at 0:11:03
> Trimipramine is the best drug I've ever tried that is classified as an antidepressant.
>
> -undopaminergic
>That is interesting. Many people are quite satisfied with Trimipramine albeit it doesn't exhibit any Reuptake-Properties...
F*CK knows how these drugs work O_o
Posted by Skeletor on November 11, 2020, at 15:41:16
In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10
Today's poop was really hard to pass... O_o
Posted by ed_uk2010 on November 13, 2020, at 18:36:37
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 11, 2020, at 15:41:16
> Today's poop was really hard to pass... O_o
Nortriptyline can be constipating yeah, take a stool softener.
And yes, I've taken amitriptyline.
Posted by Skeletor on November 14, 2020, at 5:27:33
In reply to Re: Currently on low dose Nortriptyline but not sure.. » Skeletor, posted by ed_uk2010 on November 13, 2020, at 18:36:37
>
> And yes, I've taken amitriptyline.
>
>How was your experience?
Posted by ed_uk2010 on November 14, 2020, at 10:21:44
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 14, 2020, at 5:27:33
> >
> > And yes, I've taken amitriptyline.
> >
> >
>
> How was your experience?It was too anticholinergic, although the drowsiness does reduce over time.
Typically, nortriptyline is more tolerable.
Posted by Skeletor on November 15, 2020, at 8:36:14
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by ed_uk2010 on November 14, 2020, at 10:21:44
Not sure what to make of it.
One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it". It also f*cks with my teeth enamel...
Posted by undopaminergic on November 15, 2020, at 8:39:07
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 15, 2020, at 8:36:14
> Not sure what to make of it.
>
> One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
>Interesting.
> It also f*cks with my teeth enamel...
Just keep the acids neutralised.
-undopaminergic
Posted by Skeletor on November 15, 2020, at 8:44:56
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 15, 2020, at 8:39:07
> > Not sure what to make of it.
> >
> > One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
> >
>
> Interesting.
>
> > It also f*cks with my teeth enamel...
>
> Just keep the acids neutralised.
>
> -undopaminergic
>Interesting and somewhat paradoxal. I am continuing the test.
I bought a high concentrated fluoride toothpaste. Hope it will help to counter negative effects.
Posted by undopaminergic on November 15, 2020, at 9:19:17
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on November 15, 2020, at 8:44:56
> > > Not sure what to make of it.
> > >
> > > One the one hand, it kinda gives me a motivational push, but on the other hand I feel dysphoric and "out of it".
> > >
> >
> > Interesting.
> >
> > > It also f*cks with my teeth enamel...
> >
> > Just keep the acids neutralised.
> >
> > -undopaminergic
> >
>
> Interesting and somewhat paradoxal. I am continuing the test.
>
> I bought a high concentrated fluoride toothpaste. Hope it will help to counter negative effects.
>Some (eg. the holistic medicine proponents) say that fluoride can have adverse effects, notably on intelligence. I'd use xylitol and/or baking soda.
That said, I use flouride toothpaste myself, because of inertia (I'm too lazy and/or apathetic to arrange for better alternatives).
-undopaminergic
Posted by Lamdage22 on November 16, 2020, at 6:16:21
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 15, 2020, at 9:19:17
There are people who have flouride allergy. Their teeth are rotten.
Posted by Skeletor on November 16, 2020, at 9:35:31
In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10
Increased to 15mg of Nortriptyline.
So far: Bouts of Dysphoria, hot flashes and restlessness. Motivational spikes...
Posted by Skeletor on November 16, 2020, at 11:18:30
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 16, 2020, at 9:35:31
Some soft poop today... no diarrhea, but something in-between normal poop and diarrhea.
Posted by Skeletor on November 25, 2020, at 13:20:53
In reply to Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 8, 2020, at 10:35:10
Nortriptyline seems to make my "OCD" worse xD I've been obsessing about stupid stuff and was kinda anxious. NRIs do that? Generally speaking?
Although I am unsure if the worsening of OCDish features causes the anxiety or the other way around... sometimes it is difficult to distinguish
Yesterday...It was 23:30 PM... I still had 15 liters of fuel n my car-tank, but wanted to fill it up... first gas station was closed, the second one was too expensive, the third one was closing.... the forth too expensive, the fifth... closed and so on....I drove through half of Hamburg until I finally found a cheap open gas station....
totally obsessive and dumb... I surely made 35km and an hour of driving xD
That's what NTP does to me... but I am unsure which component causes it.
Presumably NRIs can cause agitation, anxiety, headache, restlessness and OCDish like side effects, but not sure ^^
Posted by Skeletor on December 9, 2020, at 9:30:07
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on November 25, 2020, at 13:20:53
Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...
Weight has gone down. Shakiness and tremor has gone up.
Motivation has gone up. Wastefulness has gone up.
Posted by undopaminergic on December 9, 2020, at 10:57:20
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by Skeletor on December 9, 2020, at 9:30:07
> Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...
>
> Weight has gone down. Shakiness and tremor has gone up.
>
> Motivation has gone up. Wastefulness has gone up.What about the teeth?
-undopaminergic
Posted by Skeletor on December 9, 2020, at 11:01:08
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on December 9, 2020, at 10:57:20
> > Up to 25mg. My anxiety and agitation is definitely up. Feeling edgy and jumpy...
> >
> > Weight has gone down. Shakiness and tremor has gone up.
> >
> > Motivation has gone up. Wastefulness has gone up.
>
> What about the teeth?
>
> -undopaminergic
>Dry mouth got somewhat better. Actually a dry sore throat is the bigger problem.
I was at the dentist and he prescribed special drops to stimulate salvia production and release.
Posted by undopaminergic on December 9, 2020, at 11:13:04
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on December 9, 2020, at 11:01:08
> > What about the teeth?
> >
> > -undopaminergic
> >
>
> Dry mouth got somewhat better. Actually a dry sore throat is the bigger problem.
>
> I was at the dentist and he prescribed special drops to stimulate salvia production and release.
>Interesting. What's the active ingredient? (I imagine it is a cholinomimetic.)
-undopaminergic
Posted by Skeletor on December 9, 2020, at 17:28:15
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on December 9, 2020, at 11:13:04
> > > What about the teeth?
> > >
> > > -undopaminergic
> > >
> >
> > Dry mouth got somewhat better. Actually a dry sore throat is the bigger problem.
> >
> > I was at the dentist and he prescribed special drops to stimulate salvia production and release.
> >
>
> Interesting. What's the active ingredient? (I imagine it is a cholinomimetic.)
>
> -undopaminergic
>Pilocarpine solution and Anethole trithione dragées. I did get both.
Posted by undopaminergic on December 10, 2020, at 3:26:48
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on December 9, 2020, at 17:28:15
> > > I was at the dentist and he prescribed special drops to stimulate salvia production and release.
> > >
> >
> > Interesting. What's the active ingredient? (I imagine it is a cholinomimetic.)
> >
> > -undopaminergic
> >
>
> Pilocarpine solution and Anethole trithione dragées. I did get both.I knew about pilocarpine, but anethole trithione is new to me.
-undopaminergic
Posted by Skeletor on December 10, 2020, at 17:48:25
In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on December 10, 2020, at 3:26:48
> -undopaminergic
I've always been a rather edgy and jumpy person, agitated with high motor restlessness. In fight or flight mode all the time. Tunnel vision. What I find interesting: Nortriptyline seems to make it worse.
I've always thought that my problem might be a lowish level of Noradrenaline, maybe some form of ADHD, but right now I think that it might exactly the opposite: too much Noradrenaline. Would at least explain my scrawny body.
Maybe some form of Noradrenaline producing "benign" tumour?
Posted by undopaminergic on December 11, 2020, at 9:09:04
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on December 10, 2020, at 17:48:25
> > -undopaminergic
>
> I've always been a rather edgy and jumpy person, agitated with high motor restlessness. In fight or flight mode all the time. Tunnel vision. What I find interesting: Nortriptyline seems to make it worse.
>
> I've always thought that my problem might be a lowish level of Noradrenaline, maybe some form of ADHD, but right now I think that it might exactly the opposite: too much Noradrenaline. Would at least explain my scrawny body.
>
> Maybe some form of Noradrenaline producing "benign" tumour?Do you have hypertension? Tremor? Dilated pupils? Other hyperadrenergic symptoms?
-undopaminergic
Posted by Skeletor on December 11, 2020, at 12:44:17
In reply to Re: Currently on low dose Nortriptyline but not sure.. » Skeletor, posted by undopaminergic on December 11, 2020, at 9:09:04
> > > -undopaminergic
> >
> > I've always been a rather edgy and jumpy person, agitated with high motor restlessness. In fight or flight mode all the time. Tunnel vision. What I find interesting: Nortriptyline seems to make it worse.
> >
> > I've always thought that my problem might be a lowish level of Noradrenaline, maybe some form of ADHD, but right now I think that it might exactly the opposite: too much Noradrenaline. Would at least explain my scrawny body.
> >
> > Maybe some form of Noradrenaline producing "benign" tumour?
>
> Do you have hypertension? Tremor? Dilated pupils? Other hyperadrenergic symptoms?
>
> -undopaminergic
>Dilated pupils and tremor quite often, but no hypertension. On the contrary: I often have low blood pressure and consequently headaches. I am quite skinny and pale, with rather low body temperature.
What would be other symptoms of hyperadrenergia?
Posted by undopaminergic on December 12, 2020, at 0:37:51
In reply to Re: Currently on low dose Nortriptyline but not sure.. » undopaminergic, posted by Skeletor on December 11, 2020, at 12:44:17
> > >
> > > Maybe some form of Noradrenaline producing "benign" tumour?
> >
> > Do you have hypertension? Tremor? Dilated pupils? Other hyperadrenergic symptoms?
> >
> > -undopaminergic
> >
>
> Dilated pupils and tremor quite often, but no hypertension. On the contrary: I often have low blood pressure and consequently headaches. I am quite skinny and pale, with rather low body temperature.
>
> What would be other symptoms of hyperadrenergia?Eg. sweating, lack of nasal congestion. Increased heart rate, if it's more adrenaline rather than noradrenaline. "Shaky" voice. There are others, but I can't remember at the moment -- maybe check Wikipedia?
I would expect increased central body temperature from high (nor)adrenaline, and/or decreased peripheral temperature (which manifests especially as cold extremities).
Have you checked your thyroid hormone levels?
Have you tried anti-adrenergic agents, such as propranolol, guanfacine, clonidine (and others)?
-undopaminergic
Posted by Skeletor on December 18, 2020, at 18:09:55
In reply to Re: Currently on low dose Nortriptyline but not sure.. » Skeletor, posted by undopaminergic on December 12, 2020, at 0:37:51
> > > >
> > > > Maybe some form of Noradrenaline producing "benign" tumour?
> > >
> > > Do you have hypertension? Tremor? Dilated pupils? Other hyperadrenergic symptoms?
> > >
> > > -undopaminergic
> > >
> >
> > Dilated pupils and tremor quite often, but no hypertension. On the contrary: I often have low blood pressure and consequently headaches. I am quite skinny and pale, with rather low body temperature.
> >
> > What would be other symptoms of hyperadrenergia?
>
> Eg. sweating, lack of nasal congestion. Increased heart rate, if it's more adrenaline rather than noradrenaline. "Shaky" voice. There are others, but I can't remember at the moment -- maybe check Wikipedia?
>
> I would expect increased central body temperature from high (nor)adrenaline, and/or decreased peripheral temperature (which manifests especially as cold extremities).
>
> Have you checked your thyroid hormone levels?
>
> Have you tried anti-adrenergic agents, such as propranolol, guanfacine, clonidine (and others)?
>
> -undopaminergic
>No sweating and no lack of nasal congestion. Heart rate is increased. Increased central body temperature and decreased peripheral temperature is spot on...
thyroid hormone levels are okay, although they weren't in the past....I haven't tried anti-adrenergic agents yet... I wanted to try propranolol, but haven't come to it yet.
With drugs like Nortriptyline it's kinda difficult to distinguish the different effects: might be caused by NRI, or might be caused by anticholinergic properties, or might be caused by 5HT2 antagonism... f*ck knows!
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
[email protected]
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