Psycho-Babble Medication Thread 1099213

Shown: posts 1 to 5 of 5. This is the beginning of the thread.

Benzos more rapid onst of action?

Posted by Lamdage22 on June 19, 2018, at 11:54:07

Intranasal midazolam? Sublingual? Anyone. I want an immediate onset of action.

Re: Benzos more rapid onst of action?

Posted by sigismund on June 19, 2018, at 14:28:15

In reply to Benzos more rapid onst of action?, posted by Lamdage22 on June 19, 2018, at 11:54:07

Sublingual diazepam is very quick.

Re: Benzos more rapid onst of action? » sigismund

Posted by ed_uk2010 on June 19, 2018, at 15:30:58

In reply to Re: Benzos more rapid onst of action?, posted by sigismund on June 19, 2018, at 14:28:15

>Sublingual diazepam is very quick.

Yep, it is very fast acting. No doubt you will get told otherwise (eg. a lot of doctors claim lorazepam works more rapidly, but it doesn't).

Diazepam on a empty stomach works much more quickly than most benzos. It is interesting how few doctors realise this.

Re: Benzos more rapid onst of action? » ed_uk2010

Posted by beckett2 on June 20, 2018, at 17:40:13

In reply to Re: Benzos more rapid onst of action? » sigismund, posted by ed_uk2010 on June 19, 2018, at 15:30:58

> >Sublingual diazepam is very quick.
>
> Yep, it is very fast acting. No doubt you will get told otherwise (eg. a lot of doctors claim lorazepam works more rapidly, but it doesn't).
>
> Diazepam on a empty stomach works much more quickly than most benzos. It is interesting how few doctors realise this.
>
>

Faster than sublingual alprazolam?

Re: Benzos more rapid onst of action? » beckett2

Posted by ed_uk2010 on June 21, 2018, at 17:20:28

In reply to Re: Benzos more rapid onst of action? » ed_uk2010, posted by beckett2 on June 20, 2018, at 17:40:13

>Faster than sublingual alprazolam?

Should be similar.

Sublingual administration doesn't speed the onset of alprazolam, however, beyond a placebo effect. Sublingually administered alprazolam taken without water is absorbed more slowly than a plain alprazolam tablet swallowed whole with a glass of water. The reason is that alprazolam and other benzos are absorbed predominantly from the GI tract, not the mouth, and that a glass of water speeds absorption. A tablet swallowed on an empty stomach with a full glass of water will take effect most rapidly.

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