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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by rjlockhart37 on May 30, 2018, at 23:00:48
i really didn't think much of this, deplin, but i've been a very gloomy night, i took deplin and literally noticed like my neurotransmitters were restored, it's a folate medicine a B vitamin, can't believe how much better i am doing after, its like it replenished a deficiency . I get in gloomy states, and do have some dopamine definitely, trying get things done but your just .... so sluggish, armodafinil helps with keeping going or helping, but tonight i'm much better....l-methylfolate is folic acid, a B vitamin, which synthesizes neurotransmitters
Posted by SLS on May 31, 2018, at 7:46:03
In reply to l-methyfolate rescue, posted by rjlockhart37 on May 30, 2018, at 23:00:48
> i really didn't think much of this, deplin, but i've been a very gloomy night, i took deplin and literally noticed like my neurotransmitters were restored, it's a folate medicine a B vitamin, can't believe how much better i am doing after, its like it replenished a deficiency . I get in gloomy states, and do have some dopamine definitely, trying get things done but your just .... so sluggish, armodafinil helps with keeping going or helping, but tonight i'm much better....l-methylfolate is folic acid, a B vitamin, which synthesizes neurotransmitters
The big question is whether or not L-methylfolate can produce a persistent and stable antidepressant effect. I experienced an improvement in my bipolar depression early in treatment with Deplin, but it quickly fizzled out.
- Scott
Posted by Christ_empowered on May 31, 2018, at 13:17:57
In reply to Re: l-methyfolate rescue, posted by SLS on May 31, 2018, at 7:46:03
hi. I"m glad it helped. I do Orthomolecular, which involves fairly high doses of all the b-vitmains, plus lots of B3 (niacinamide, in my case). And..
as much as I'd like to believe that the vitamins are somehow "correcting" problems, I think its more like...
massive doses of combinations of vitamins can do things, over time, that pharmaceuticals do, at a lower cost and with less toxicity. Oh, and the "alternative" health people say that Orthomolecular produces "side -benefits- " as opposed to "sid effects" (adverse effects) from standard psych drugs.
I don't think anyone -needs- 6grams/B3 (my current dose), but taking 6 grams/B3 daily helps me simmer down...it helps the anxiety and obsessive weirdness, and I'm spared an SSRI or Anafranil. Life is good.
Posted by PeterMartin on June 1, 2018, at 8:24:39
In reply to Re: l-methyfolate rescue, posted by Christ_empowered on May 31, 2018, at 13:17:57
If you take Lamictal be aware that methyfolate can reduce its effectiveness significantly. There was a study a couple years back which discovered that.
Posted by SLS on June 2, 2018, at 10:57:39
In reply to Re: l-methyfolate rescue, posted by PeterMartin on June 1, 2018, at 8:24:39
> If you take Lamictal be aware that methyfolate can reduce its effectiveness significantly. There was a study a couple years back which discovered that.
That's interesting. I take Lamictal for bipolar depression. I found myself feeling worse on L-methylfolate after experiencing an initial improvement. Do you know the reason why the efficacy of Lamictal is reduced?
Thanks.
- Scott
Posted by PeterMartin on June 2, 2018, at 20:44:39
In reply to Re: l-methyfolate rescue » PeterMartin, posted by SLS on June 2, 2018, at 10:57:39
> >I found myself feeling worse on L-methylfolate after experiencing an initial improvement. Do you know the reason why the efficacy of Lamictal is reduced?
>
> Thanks.
>
>
> - ScottThis is where that info came from - thoughts?
"Folic acid seems to nullify the effect of lamotrigine."
https://www.sciencedirect.com/science/article/pii/S2215036615004502
===
Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial
Background
Depressive symptoms are a major cause of disability in bipolar disorder and there are few safe and effective treatments. The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. We aimed to determine if combination therapy with quetiapine plus lamotrigine leads to greater improvement in depressive symptoms over 12 weeks than quetiapine monotherapy plus lamotrigine placebo.Methods
In this double-blind, randomised, placebo-controlled, parallel group, 2 × 2 factorial trial (CEQUEL), patients with DSM-IV bipolar disorder I or II, who were aged 16 years or older, and required new treatment for a depressive episode, were enrolled from 27 sites in the UK. Patients were randomly assigned (1:1) by an adaptive minimisation algorithm to lamotrigine or placebo and to folic acid or placebo. Participants and investigators were masked to the treatment groups. The primary outcome was improvement in depressive symptoms at 12 weeks with the Quick Inventory of Depressive Symptomatologyself report version 16 (QIDS-SR16). Analysis was by modified intention-to-treat. This trial is registered with EUdraCT, number 2007-004513-33.Findings
Between Oct 21, 2008, and April 27, 2012, 202 participants were randomly assigned; 101 to lamotrigine and 101 to placebo. The mean difference in QIDS-SR16 total score between the group receiving lamotrigine versus the placebo group at 12 weeks was −1·73 ([95% CI −3·57 to 0·11]; p=0·066) and at 52 weeks was −2·69 ([4·89 to −0·49]; p=0·017). Folic acid was not superior to placebo. There was a significant interaction (p=0·028), with folic acid reducing the effectiveness of lamotrigine at 12 weeks. The mean difference on QIDS-SR16 was −4·14 ([95% CI −6·90 to −1·37]; p=0·004) for patients receiving lamotrigine without folic acid compared with 0·12 ([2·58 to 2·82]; p=0·931) for those receiving lamotrigine and folic acid.Interpretation
Addition of lamotrigine to quetiapine treatment improved outcomes. Folic acid seems to nullify the effect of lamotrigine. CEQUEL should encourage clinicians and patients to consider lamotrigine for bipolar depression, but also to be aware that concurrent folic acid might reduce its effectiveness.
Posted by Lamdage22 on June 3, 2018, at 7:06:28
In reply to Re: l-methyfolate rescue, posted by PeterMartin on June 2, 2018, at 20:44:39
I take 5mg methylfolate. My doctor said folate was too high. I hear that Metformin can increase folate
Posted by rjlockhart37 on June 3, 2018, at 21:09:30
In reply to Re: l-methyfolate rescue, posted by Lamdage22 on June 3, 2018, at 7:06:28
its a more direct form of folate, it works directly .... i've noticed it has helped me when im in slumps, or gloomy nights.....even while on caffeine i still feel gloomy, i took dose 15-30mg and noticed improvement
Posted by rjlockhart37 on June 15, 2018, at 22:21:50
In reply to Re: l-methyfolate rescue, posted by rjlockhart37 on June 3, 2018, at 21:09:30
i had another gloomy night, tonight, even with coffee, took it again, there must be like a depletion of neurotransmitters, some days im doing ok, others im sluggy, but i read that l-methylfolate is the synthesis of making neurotransmitters, when there low even with coffee or prozac your alert, but your in gloomy mood
This is the end of the thread.
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