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Dr. Bob is Robert Hsiung, MD,
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Posted by Phillipa on May 10, 2016, at 20:51:24
News Alerts > Medscape Medical News
Olanzapine Linked to Rare but Serious Skin Reaction, FDA Warns
Caroline Cassels
Disclosures | May 10, 2016
Depression
Depression and Suicide
Postpartum Depression
The US Food and Drug Administration (FDA) is warning that the antipsychotic olanzapine (multiple brands) has been linked to a severe condition known as drug reaction with eosinophilia and systemic symptoms (DRESS).The FDA Adverse Event Reporting System (FAERS) database identified 23 cases of DRESS reported with olanzapine worldwide since 1996, when the first olanzapine-containing product was approved.
In a release, the FDA notes that FAERS includes only reports submitted to the agency, so there are likely to be additional cases of which the FDA is unaware.
It reports that one patient taking olanzapine experienced DRESS and died; however, this patient was taking multiple medicines that could have contributed to death.
DRESS may start as a rash that can spread to all parts of the body. It can include fever, swollen lymph nodes, and a swollen face. It causes a higher-than-normal eosinophil count that can cause inflammation or swelling. DRESS can result in injury to organs, including the liver, kidneys, lungs, heart, or pancreas, and can lead to death. DRESS is a potentially fatal drug reaction with a mortality rate of up to 10%.
The FDA recommends that physicians immediately stop treatment with olanzapine if DRESS is suspected. There is currently no specific treatment for DRESS. The important ways to manage DRESS are early recognition of the syndrome, discontinuation of the offending agent as soon as possible, and supportive care.
Treatment with systemic corticosteroids should be considered in cases with extensive organ involvement. When prescribing the medicine, physicians should explain the signs and symptoms of severe skin reactions to their patients and should tell them when to seek immediate medical care.
To report any problems associated with the use of olanzapine, visit www.fda.gov/MedWatch or call 1-800-332-1088.
Posted by Phillipa on May 10, 2016, at 20:54:49
In reply to Zyprexa not identified with rare side effects READ, posted by Phillipa on May 10, 2016, at 20:51:24
All forms of this medication. This was received as an FDA news Alert. Phillipa
Posted by J Kelly on May 10, 2016, at 21:35:22
In reply to Zyprexa not identified with rare side effects READ, posted by Phillipa on May 10, 2016, at 20:51:24
"Jade yes they said rare. Seems always a scare about some medication. Phillipa"
And another one :(
Jade
Posted by Phillipa on May 10, 2016, at 22:44:11
In reply to Re: Zyprexa not identified with rare side effects READ » Phillipa, posted by J Kelly on May 10, 2016, at 21:35:22
I know started with motrin, tylenol, The statins the benzos and now more and more?
Posted by rjlockhart37 on May 12, 2016, at 13:37:26
In reply to Zyprexa not identified with rare side effects READ, posted by Phillipa on May 10, 2016, at 20:51:24
that defeintly sounds concerning, the problem i have (had) with zyprexa is weight gain, and sedation, i noticed zyprexa made me very quiet, its like i never have anything to say when i take it, it just .... chills out the mind and your just feel passive
when i don't zyprexa after several days i notice i talk alot more, but also get irrtibile
diabetes is associated with olanzipine use, that still concerns me because i have been on zyprexa for 7 years
Posted by Zyprexa on May 12, 2016, at 19:40:41
In reply to Re: Zyprexa not identified with rare side effects READ, posted by rjlockhart37 on May 12, 2016, at 13:37:26
I've been taking zyprexa for 19 years now and it never made me diabetic. I even had low sugars for a while when I was eating super healthy.
This is the end of the thread.
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