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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by revv33 on May 1, 2016, at 12:33:21
I was wondering if anyone here knows if Rexulti affect less recptors then Abilify? From reading the wikis it looks like it, but maybe they left some of them out?
I don't know but I was just wondering because Abilify seems to be I think plus anyone know if Rexulti would be less likely to cause sexual problems?
I believe Rexulti affects the d2 receptors less then Abilify but I could be wrong... and if it does affect them less would it mean less sexual problems possibly? I know dosage affects this also but im talking if it is 1:1
Posted by J Kelly on May 1, 2016, at 12:44:54
In reply to Does Rexulti affect less receptors then Abilify?, posted by revv33 on May 1, 2016, at 12:33:21
> I was wondering if anyone here knows if Rexulti affect less recptors then Abilify? From reading the wikis it looks like it, but maybe they left some of them out?
>
> I don't know but I was just wondering because Abilify seems to be I think plus anyone know if Rexulti would be less likely to cause sexual problems?
>> I believe Rexulti affects the d2 receptors less then Abilify but I could be wrong... and if it does affect them less would it mean less sexual problems possibly? I know dosage affects this also but im talking if it is 1:1
Hope this helps :)
Jade
Posted by revv33 on May 1, 2016, at 12:48:22
In reply to Re: Does Rexulti affect less receptors then Abilify? » revv33, posted by J Kelly on May 1, 2016, at 12:44:54
> > I was wondering if anyone here knows if Rexulti affect less recptors then Abilify? From reading the wikis it looks like it, but maybe they left some of them out?
> >
> > I don't know but I was just wondering because Abilify seems to be I think plus anyone know if Rexulti would be less likely to cause sexual problems?
> >
>
> > I believe Rexulti affects the d2 receptors less then Abilify but I could be wrong... and if it does affect them less would it mean less sexual problems possibly? I know dosage affects this also but im talking if it is 1:1
>
> http://mentalhealthdaily.com/2015/08/12/rexulti-brexpiprazole-approved-for-schizophrenia-depression-adjunct/
>
> Hope this helps :)
>
> Jade
>
>
If it affects serotonergic receptors does that mean I could get Permanent Post Sexual Dysfunction from it?
Posted by revv33 on May 1, 2016, at 12:54:29
In reply to Re: Does Rexulti affect less receptors then Abilify?, posted by revv33 on May 1, 2016, at 12:48:22
I just saw a reply saying it killed there sex drive uhg... :[
but I would be willing to give it a try I guess since I don't think it could be worse then being on abilify for sexual side effects but I could be wrong...
Posted by J Kelly on May 1, 2016, at 13:04:19
In reply to Re: Does Rexulti affect less receptors then Abilify?, posted by revv33 on May 1, 2016, at 12:48:22
> >
> If it affects serotonergic receptors does that mean I could get Permanent Post Sexual Dysfunction from it?
>I did a quick search and did not find anything to support this. Hopefully someone smarter than me will come along and present you with a better answer.
Jade
Posted by revv33 on May 1, 2016, at 13:15:18
In reply to Re: Does Rexulti affect less receptors then Abilify? » revv33, posted by J Kelly on May 1, 2016, at 13:04:19
I cant edit my post for whatever reasons but I meant persistent post ssri sexual dysfunction.
Posted by J Kelly on May 1, 2016, at 13:29:53
In reply to Re: Does Rexulti affect less receptors then Abilify?, posted by revv33 on May 1, 2016, at 13:15:18
> I cant edit my post for whatever reasons but I meant persistent post ssri sexual dysfunction.
>
>Here's an old babble thread. Maybe you'll find it useful.
URL: http://www.dr-bob.org/babble/20090818/msgs/913953.html
Jade
Btw- you cant edit a post once its been posted.
Posted by crabcakebenny on May 1, 2016, at 14:15:10
In reply to Re: Does Rexulti affect less receptors then Abilify?, posted by revv33 on May 1, 2016, at 13:15:18
Looks like it has more of an antagonist than Abilify: http://jpet.aspetjournals.org/content/350/3/589
Could be good for agitation or intrusive and paranoid thoughts.
Posted by SLS on May 1, 2016, at 16:23:52
In reply to Re: Does Rexulti affect less receptors then Abilify? » revv33, posted by J Kelly on May 1, 2016, at 12:44:54
Rexulti (brexpiprazole) is less of a D3 dopamine partial receptor agonist than is Abilify. If I understand correctly, there should be less akathisia associated with its use. Rexulti is more active at serotonin 5-HT1a receptors than is Abilify. In addition, Rexulti blocks certain norepinephrine alpha-2 receptors. I don't know what the end result would be of these actions. I guess Rexulti acts as a sort of dopamine-serotonin system modulator.
- Scott
This is the end of the thread.
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