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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by rjlockhart37 on January 16, 2015, at 10:54:31
i took my medication about 2 hours ago.....i notice the effect, the prozac im in a better mood than i have been the past couple years, but this is kinda known to work for couple days and then the effect demineshes, one thing i've been praying signifcantly for this resistance to go away, and prayer with faith can work but sometimes it seems like words into the wind.....
so.....i'm glad for right now, the prozac im noticing with the mood, lamictal is not so noticable.....
hopefully this is going to start to end, and ill be in a better state
just had to write that down
r
Posted by rjlockhart37 on January 16, 2015, at 16:25:33
In reply to medicine worked this morning, posted by rjlockhart37 on January 16, 2015, at 10:54:31
so.....it leveled out though the day, it was working htis morning which was just.....i noticed the prozac pep feeling, but it demished with in 3 hours later, see i was on prozac since 2005, and when i move it to 40mg it made me slightly hypomanic, i was too happy and bubbly, if a drank an energy drink iwth it, it would just make me unnatrually happy......but after went by, and the main which i have written since 2010 most of medications lost their sensitivty.....
but .... hopefully thing are going to work, if i have to beg god, to return me back to normal, maybe it will happen....just knowing if i could come out of the gloom period from 2011-15......i hope it will end
but things are always better if you believe it will get better, choosing to stay pessimistic and cynical leads to misery
r
Posted by Zyprexa on January 16, 2015, at 22:18:42
In reply to medicine worked this morning, posted by rjlockhart37 on January 16, 2015, at 10:54:31
So have you been off all your meds for 8 days now?
Posted by ed_uk2010 on January 17, 2015, at 14:12:12
In reply to Re: medicine worked this morning, posted by rjlockhart37 on January 16, 2015, at 16:25:33
>i noticed the prozac pep feeling
Prozac has a long duration of action in the body. After you have been taking it daily on a long-term basis (like you have), the drug level does not vary much throughout the day - it remains fairly constant. Any changes in mood that you notice across the day, or from day to day, are unlikely to be related to you having recently taken your dose. The changes in your mood are due to other reasons, many of which you may never know... But other reasons nonetheless - psychological, biological and situational factors etc. It's not that Prozac 'worked' today but not yesterday. Your mood has changed due to something else. Only when you first start taking Prozac do your blood levels vary significantly across the day.
Posted by rjlockhart37 on January 17, 2015, at 23:32:10
In reply to Re: medicine worked this morning, posted by ed_uk2010 on January 17, 2015, at 14:12:12
yea.....you said something about blood levels vary, that does kinda make since because, first my body has changed vary much since 2009, because in 2010 is when i started having this problem with the resistance, and it's been vary difficult these past years, up and down, but the way prozac works for me, it just ... i don't have the feeling o being in a dump, and previous 2010 it would give a since of content, not euphoria or pleasure, just feeling of content, not being depressed and noticing life better.....
the one thing i wanted to ask, if i eat, you said some thing abou the blood levels.... the chemistry of it, could they change because my body has defiently changed since 2010......and it's difficult to figure out the problem with no obvious signs of that it's a problem.....
the nuvigil used to wake me up, not speedy wake like adderall, but it just promotes to be awake, and sometimes like i said it doenst, i go right back to sleep and sleep hard, until later in the day, and iddnt notice it, thats when it started to bother me, like my body changed....absorbation, something in blood levels that flucuate, the thing is i don't know the problem
it's making me really depressed just thinking about it, thomatheus and herpills advised to get the vita D checked, i can start to get on supplement, just paranoid about a problem thats going undected, thinking i have a absorbation problem, too much agitation thinking about it
advanced tests would have to be done and too costly.....
is there anything you think i test could do? check blood levels to see if it's being absorbed?
Posted by rjlockhart37 on January 17, 2015, at 23:43:45
In reply to Re: medicine worked this morning, posted by ed_uk2010 on January 17, 2015, at 14:12:12
like it worked this morning, well it could of been a placebo effect, but i felt better, and some days i do notice the nuvigil but only works for short time then my body just levelizes everything.....to where there's no noticed alteration
the one thing i have noticed is not severe depression, yet it's up and down, this problem is figuring out what kind of needle is hidden in the hey stack
Posted by ed_uk2010 on January 18, 2015, at 6:59:33
In reply to Re: medicine worked this morning, posted by rjlockhart37 on January 17, 2015, at 23:43:45
>like it worked this morning, well it could of been a placebo effect, but i felt better, and some days i do notice the nuvigil but only works for short time then my body just levelizes everything.....to where there's no noticed alteration
It could have been a placebo effect.... but more likely you're just like the rest of us in that you have good days and bad days. You may have fewer or less severe bad days with meds but they don't eliminate unpleasant emotions.
>this problem is figuring out what kind of needle is hidden in the hey stack
I think part of the problem is that you attribute everything to your medication. It's very likely that most of the emotions you feel are not because of your meds.... or only partly related to them. There are so many other things which affect mood apart from meds.
Posted by ed_uk2010 on January 18, 2015, at 7:32:08
In reply to Re: medicine worked this morning, posted by rjlockhart37 on January 17, 2015, at 23:32:10
Hi RJ,
> yea.....you said something about blood levels vary, that does kinda make sense because, first my body has changed vary much since 2009, because in 2010 is when i started having this problem with the resistance, and it's been vary difficult these past years, up and down, but the way prozac works for me, it just ... i don't have the feeling o being in a dump, and previous 2010 it would give a since of content, not euphoria or pleasure, just feeling of content, not being depressed and noticing life better.....
SSRIs are other ADs often help to some extent, but many people with long-term mental health problems still continue to have symptoms, often at a less severe level. This is not in any way unusual - you are not alone or different here. I think you think you are, but you're not.
>the one thing i wanted to ask, if i eat, you said some thing about the blood levels.... the chemistry of it, could they change because my body has defiently changed since 2010......and it's difficult to figure out the problem with no obvious signs of that it's a problem.....
The blood levels of Prozac stay almost constant during long-term use. This is because it is slowly metabolised and eliminated. You don't need to worry about your Prozac levels changing throughout the day - this is normally only an issue with short acting antidepressants like Effexor.
>the nuvigil used to wake me up, not speedy wake like adderall, but it just promotes to be awake, and sometimes like i said it doenst, i go right back to sleep and sleep hard, until later in the day, and iddnt notice it, thats when it started to bother me, like my body
Some degree of tolerance can happen to stimulants and related drugs after regular use. This occurs mainly because the brain adjusts itself and adapts to reduce the med's effects.
...............................................................
A relevant factor for some people is smoking. Smoking increases the metabolism and elimination of certain drugs, including Zyprexa.... this reduces blood levels and weakens the effects of the medication. Stopping smoking may increase levels of Zyprexa and increase the effects. The change in levels is not caused by nicotine, it is due to other ingredients in tobacco smoke. As a result, using nicotine patches or electronic cigarettes does not reduce medication levels like smoking does. Bear in mind, smoking only affects certain meds.
>....absorbation, something in blood levels that flucuate, the thing is i don't know the problem
No, the problem is not due to changes in med absorption. Unless you have a serious intestinal condition, which you would know about if you did, you should be absorbing your meds fine.
>it's making me really depressed just thinking about it, thomatheus and herpills advised to get the vita D checked, i can start to get on supplement, just paranoid about a problem thats going undected, thinking i have a absorbation problem, too much agitation thinking about it
You don't need any advanced tests for absorption of medication. If there's one thing I can say it's that your problems are not due to changes in med absorption. That is not something that just happens.
If you regularly feel very depressed and tired, there are various simple blood tests which can be done by your doctor. These are all routine tests, nothing unusual. If you haven't had any blood tests recently you could see your GP/family doc for advice. Here are some examples...
A complete blood count - checks for anemia which can cause tiredness. If anaemia is detected, further blood tests can be performed to find the cause eg. iron deficiency, folic acid deficiency, vitamin B12 deficiency etc.
Liver panel - abnormalities may be caused by many factors. One factor can be too much alcohol, which can aggravate mental health problems and fatigue.
Thyroid function tests - abnormal thyroid function can sometimes cause symptoms similar to depression and anxiety disorders. Many people with thyroid illness also have a mental health problem, however.
Blood glucose - diabetes is a common cause of fatigue so doctors increasingly check glucose, especially if people also feel thirsty and pee a lot, or have blurry vision. Zyprexa can increase the risk of diabetes so regular monitoring is important. People on Zyprexa should also monitor their weight and have their lipids checked (cholesterol level and triglycerides etc).
ESR or plasma viscosity - this is a vague test to look for inflammatory disorders. It cannot diagnose anything on its own, but if the results are abnormal it requires further investigation.
These blood tests often come back normal but the purpose is sometimes just to rule out additional medical problems which can be contributing to your mental health problems.
Posted by Zyprexa on January 18, 2015, at 8:05:12
In reply to Smoking and other issues, posted by ed_uk2010 on January 18, 2015, at 7:32:08
I'm glade to hear that its the tobaco and not the nicotine that eliminates zyprexa. I've almost quit tobaco for the e cig.
Posted by Zyprexa on January 18, 2015, at 8:14:00
In reply to Smoking and other issues, posted by ed_uk2010 on January 18, 2015, at 7:32:08
How does alcohol affect zyprexa and other meds?
Posted by ed_uk2010 on January 18, 2015, at 9:05:57
In reply to Re: Smoking and other issues, posted by Zyprexa on January 18, 2015, at 8:14:00
>How does alcohol affect zyprexa and other meds?
It depends on the med... but the interaction is complex because it also differs depending on the type of alcohol intake. There are metabolic interactions .......and other interactions based on the pharmacological effects of alcohol.
Metabolic interactions:
1. Intoxication with alcohol can raise the levels of some meds. This is due to the acute inhibition of certain drug metabolising liver enzymes eg. CYP2E1 and CYP3A4.
2. Regular substantial alcohol use (excluding periods of intoxication) can reduce the blood levels of some meds. This is due to increased production of certain drug metabolising liver enzymes (mainly CYP2E1 and CYP3A4). Note that these are the same enzymes whose function can be inhibited during intoxication.
3. Small amounts of alcohol drunk intermittently do not affect the levels of most meds very much or at all.
4. Liver damage in chronic alcohol abusers may lead to the rise the blood levels of some drugs, and resulting toxicity. Electrolyte imbalances may predispose to cardiac toxicity and confusion.
Due to points 1 and 2, heavy drinkers may experience toxic drug levels during periods of intoxication and subtherapeutic levels (or withdrawal symptoms) the rest of the time. Common meds and psych drugs likely to be affected on a metabolic level by alcohol include acetaminophen (Tylenol, paracetamol), warfarin, some benzos (especially Xanax and Klonopin), Ambien, Lunesta, Remeron, trazodone, some tricyclic antidepressants, Depakote, Tegretol, Seroquel and methadone. Heavy drinking in combination with the likes of Xanax, Klonopin and methadone has resulted in fatalities. Sedation, amnesia, strange behavior, confusion and respiratory depression can occur. The interaction is more than a metabolic interaction because alcohol can also greatly potentiate the central nervous system depression produced by other drugs.
Pharmacological interactions:
1. Regular use of alcohol (except small/occasional quantities) may make antipsychotics less effective. Alcohol should be avoided in psychosis.
2. Alcohol can cause excessive sedation in combination with most sedative drugs, including antipsychotics. This is also the case for drugs such as Zyprexa where there is little evidence of any metabolic interaction.
Alcohol should be avoided with all benzos, opiates, Ambien and Lunesta. People often drink with these meds and think they're fine.... until something bad happens on the occasion they have too much (or when they stop after regular use). How much is too much? Not predictable in advance... Use of alcohol and benzos/sleep drugs together often leads to periods of intoxication, memory loss and disinhibited behavior followed by highly unpleasant periods of withdrawal, followed by further intoxication etc. Obviously, this not the route to health! It does, however, appear to be the standard way that celebrities die young.
3. Regular heavy drinking may lead to liver damage when combined with other drugs which can affect the liver eg. Depakote.
4. Heavy alcohol use with bupropion (Wellbutrin, Zyban) may result in seizures and lack of antidepressant efficacy.
....................................
My advice with Zyprexa is that people who are new to it should not drink at all, nor should people drink while psychotic. Once stable on Zyprexa, small amounts of alcohol socially may be OK, but response may vary. Regular drinking is a bad idea.... and alcohol binges on Zyprexa could be dangerous. Smoking affects the blood levels of Zyprexa far more than alcohol, but alcohol may affect the clinical effects of Zyprexa through other mechanisms. As a result, alcohol excess may be harmful for mental health while on Zyprexa. Smoking, of course, is very harmful physically (as is alcohol abuse!). Chronic lung disease or liver disease is an awful way to die. Smoking E-cigs is much less harmful to the lungs.
Posted by baseball55 on January 18, 2015, at 19:32:28
In reply to Re: medicine worked this morning, posted by rjlockhart37 on January 17, 2015, at 23:32:10
>
> it's making me really depressed just thinking about it, thomatheus and herpills advised to get the vita D checked, i can start to get on supplement, just paranoid about a problem thats going undected, thinking i have a absorbation problem, too much agitation thinking about it
>
> advanced tests would have to be done and too costly.....
>
> is there anything you think i test could do? check blood levels to see if it's being absorbed?
>
>If you had an absorption problem, I would think it would effect other things as well - like absorption of nutrients. But you don't have a problem with this. I'm not sure what you mean by "absorption." I'm also not sure what you mean when you talk about low brain voltage. I don't think these are medically meaningful concepts for which there are tests.
Meds often stop working for people or they never work at all. And, like Ed says, even when meds have created some baseline mood stabilization, people still have good days and bad days.
Posted by rjlockhart37 on January 19, 2015, at 0:39:39
In reply to Re: medicine worked this morning, posted by ed_uk2010 on January 18, 2015, at 6:59:33
right meds don't manage emotions, there are some that sedate them, but taking tranqilzers all the time in some people is blocking how to live real life.....
so yes, learn coping skills with medications, is the best way, there always will be dr-feelgood's i've heard of a case on the news of a lady being on 13 psych meds, that is not medical treatment, thats feeding a drug addiction because lots of them where narotics
meds and coping skills, maybe having a therapist is good, to make everything levelized and stable
Posted by rjlockhart37 on January 19, 2015, at 0:47:41
In reply to Smoking and other issues, posted by ed_uk2010 on January 18, 2015, at 7:32:08
thanks ed, i read it
one thign is the thyroid test, i have a vary difficult way to get going in the day, it's like petrolem oil getting out of the bed, it used to be that.....im defeintly , next time i see my doctor is get that checked out
i have had low sugar levels but it doesnt have anything to do with this situation, when i went on a liquid diet for 3 weeks, on the last week i got weak, and i had to eat something, nearly fainted, but i notice it can be boosted fast by drinking sugared drinks, or orange juice moderate levels to get the glucose back up in the blood stream
just what ever religious faith believers i need a nudge that god will do something, worry too much about both health problems, then thinking about spirits that caused me to get me sick, if i watch these shows about possession and demonic attacks, theres a show that comes on at night about people's life accounts through the experience, it reminds me of simmilar things that happened in paranoia stages, fear, sickness, no more paranoia spirit shows for me
alright......vitamen D, and maybe a basic blood test.......just makes me agitated thinking about it, having little effect
anyways.....ughhh lol
thanks ed
r
Posted by rjlockhart37 on January 19, 2015, at 0:59:02
In reply to Re: medicine worked this morning » rjlockhart37, posted by baseball55 on January 18, 2015, at 19:32:28
yea....just maybe it's not binding onto something, im too agitated thinking about it, ill go through the day, it's really a gloomy feeling.....but the other day i took the prozac with the others, it had same feeling, that feeling of content, like everything is going be alright, then it left, when i started prozac it gave me a content feeling, it made me bubbly, and made a more laugh, gave more serotonin energy, it's all levelized now, i've taken prozac for 10 years now.....05
i just want to go back to normal and stop being in gloom phase like i've been in
thanks baseball
r
Posted by Zyprexa on January 22, 2015, at 7:49:06
In reply to Re: medicine worked this morning, posted by rjlockhart37 on January 19, 2015, at 0:59:02
If you have a hard time getting up in the morning and feel like molases. the zyprexa is working! Just drink lots of caffine.
If you have sugar cravings. the zyprexa is working!
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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