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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 25 of 32. This is the beginning of the thread.
Posted by Mogger on January 2, 2014, at 17:18:18
I thought this study might be of interested to some. Wonder if it might be safe with poly pharmacy.
ARTICLE:
Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial
Phytotherapy Research
Jayesh Sanmukhani Vimal Satodia Jaladhi Trivedi Tejas Patel Deepak Tiwari Bharat Panchal Ajay Goel Chandra Bhanu Tripathi
DOI: 10.1002/ptr.5025http://onlinelibrary.wiley.com/doi/10.1002/ptr.5025/abstract
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DISCLAIMER:
John Wiley & Sons are not responsible for the content of this
e-mail, and anything said in this e-mail does not necessarily
reflect the views or position of John Wiley & Sons.
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Posted by sigismund on January 2, 2014, at 17:52:11
In reply to Recent study on Prozac augmented with curcumin, posted by Mogger on January 2, 2014, at 17:18:18
I take around 1g/d BCM curcumin without noticeable neuro effects. But with any ADs, idk.
Posted by linkadge on January 2, 2014, at 18:47:46
In reply to Re: Recent study on Prozac augmented with curcumin, posted by sigismund on January 2, 2014, at 17:52:11
It was interesting that the curcumin monotherapy was similar to fluoxetine monotherapy.
With the relative lack of side effects (?) with curcumin, and possible additional health benefits, one wonders why it isn't a first line treatment (besides the obvious financial reasons)
Posted by Mogger on January 3, 2014, at 1:09:01
In reply to Re: Recent study on Prozac augmented with curcumin, posted by linkadge on January 2, 2014, at 18:47:46
I tried life extension's bio available curcumin a few years ago via bioperine and I must say it is powerful. Too powerful and I knew it was mixing with my meds. Perhaps the true curcumin unadultered would be more subtle as I know it doesn't get absorbed well.
Posted by linkadge on January 3, 2014, at 8:22:02
In reply to Re: Recent study on Prozac augmented with curcumin » linkadge, posted by Mogger on January 3, 2014, at 1:09:01
it apparently has mao-a inhibiting activities. I'm surprised this wasn't considered when combining it with fluoxetine.
I had some mild serotonin syndrome like effects when combining it with an SSRI
Linkadge
Posted by mogger on January 3, 2014, at 9:17:33
In reply to Re: Recent study on Prozac augmented with curcumin, posted by linkadge on January 3, 2014, at 8:22:02
Did you take a bio available form or regular?
Posted by linkadge on January 3, 2014, at 19:45:29
In reply to Re: Recent study on Prozac augmented with curcumin » linkadge, posted by mogger on January 3, 2014, at 9:17:33
just from turmeric
Posted by mogger on January 5, 2014, at 23:33:11
In reply to Re: Recent study on Prozac augmented with curcumin, posted by linkadge on January 3, 2014, at 19:45:29
Countries that heavily incorporate turmeric into their diets would ingest far more than 1000 mg a day don't you think? Wondering if psychotopic medications were more effective and perhaps used at lower doses in areas that heavily use turmeric in their diet.
Posted by Chris O on January 9, 2014, at 19:30:39
In reply to Recent study on Prozac augmented with curcumin, posted by Mogger on January 2, 2014, at 17:18:18
Fascinating study, though I remember taking New Chapter's Tumeric supplement years ago without any noticeable effects. Maybe I'll give it a go again.
Chris
Posted by mogger on January 10, 2014, at 1:31:52
In reply to Re: Recent study on Prozac augmented with curcumin, posted by Chris O on January 9, 2014, at 19:30:39
There is a huge difference in absorption I believe with turmeric. The bioperine in some formulas enhance its absorption ten fold but bioperine can have interactions with meds. I agree a fascinating study. Any product New Chapter puts out is high quality I think.
Posted by sigismund on January 11, 2014, at 21:37:58
In reply to Re: Recent study on Prozac augmented with curcumin » Chris O, posted by mogger on January 10, 2014, at 1:31:52
Then there's BCM, then soluble curcuminoids, or with phospatidylcholine type stuff.
Given the epidemiological evidence, perhaps plain turmeric cooked the Indian way (fried?) might be as good as plain curcumin.
Posted by Chris O on January 12, 2014, at 1:43:20
In reply to Re: Recent study on Prozac augmented with curcumin » Chris O, posted by mogger on January 10, 2014, at 1:31:52
Mogger:
Any idea which tumeric/curcumin brand replicates the stuff that was used in this study?
Thanks,
Chris
Posted by mogger on January 12, 2014, at 9:56:29
In reply to Re: Recent study on Prozac augmented with curcumin » mogger, posted by Chris O on January 12, 2014, at 1:43:20
Chris,
I unfortunately don't. I wonder if you can contact the researchers and see what they say?
Joseph
Posted by Chris O on January 12, 2014, at 18:50:36
In reply to Re: Recent study on Prozac augmented with curcumin » Chris O, posted by mogger on January 12, 2014, at 9:56:29
Great suggestion. I'll try it.
Chris
Posted by mogger on January 15, 2014, at 13:10:04
In reply to Re: Recent study on Prozac augmented with curcumin » mogger, posted by Chris O on January 12, 2014, at 18:50:36
This article from Dr. Michael Murray popped up in my email inbox this morning that I thought I would share. Seems it is a bio-available form of curcumin. Caveat though if you do try it be really careful for symptoms of serotonin syndrome and let your doctor know. Linkadge mentioned that he had some Serotonin Syndrome symptoms as did I when I tried Life Extension's bio-available curcumin with bioperine along with my meds. It is an interesting article.
mogger
http://doctormurray.com/?utm_source=Marketing+vs.+Science&utm_campaign=1%2F14&utm_medium=email
Posted by Chris O on January 15, 2014, at 13:20:27
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 13:10:04
Mogger:
Thanks for that. Ajay Goel, one of the study conductors, did write back to me. He said he could only recommend BCM-95, an Indian-produced brand. I wonder if there is any connection between what appears to be an all Indian group of study conductors and the company that produces this supplement? Maybe I'll give Dr. Murray's brand a try. For the past week, I've been taking Gaia herbs form of turmeric. From what I've read though, to get clinical results with curcumin, you basically have to take several grams a day. One thing I did notice over the past week of taking the turmeric supplement: I had a trunk rash (probably fungal or bacterial) for the last 6 or so weeks. It didn't seem to be going anywhere. I've gotten it in the past when it's hot and I sweat a lot. Last year, I had to treat it with some form of cortisol rub on stuff. Over the past five days, the rash has almost disappeared. I'm not sure if there is a connection with the turmeric, but if so, I'm impressed. I'll check back in if anything else dramatic happens. Not expecting much.
Chris
Posted by mogger on January 15, 2014, at 13:24:44
In reply to Re: Recent study on Prozac: Theracumin? » mogger, posted by Chris O on January 15, 2014, at 13:20:27
Chris that is great man! Sounds like the anti inflammatory properties perhaps could be causing the rash to subside. Here is what I picked up from BCM 95's website which states how theirs is bio-available. Very interesting.
"Enhancing the bioavailability of curcumin by combining curcuminoids and essential oils of turmeric with Ar turmerone was developed by Arjuna Natural Extracts Ltd. The new formulation showed blood concentrations of free, unconjugated curcumin in micromolar concentrations about 7-9 times more bioavailable compared to regular curcumin. It is retained in significant amount in the blood upto 8 hours after oral dose which are required if any clinical benefit is to accrue from ingested curcumin, based on the results of preclinical studies.This product has been trade-named as BCM-95 (Biocurcumin). Since the higher bioavailability of curcumin from BCM-95 delivers significant levels of curcumin in vivo, we evaluated the detailed safety profile of BCM-95 aspects in various animal models".
Posted by Chris O on January 15, 2014, at 13:56:18
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 13:24:44
Thanks! Not crazy about buying any supplements manufactured in India, China, or Mexico, though. Prefer that they come from a farm someplace in North America (Canada or US), with Good Manufacturing Practices certification. Even with that, I just don't trust much of anything. (I heard New Chapter was recently bought by Proctor and Gamble.) I'm just a paranoid little guy that can't get anything to work on my fr*gg*ng oh so dysfunctional brain.
Chris
Posted by mogger on January 15, 2014, at 13:58:07
In reply to Re: Recent study on Prozac: Theracumin? » mogger, posted by Chris O on January 15, 2014, at 13:56:18
I hear you Chris! Ever tried inositol 12 grams a day?
Posted by Chris O on January 15, 2014, at 16:12:45
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 13:58:07
Mogger:
You know, about 9 years ago, I started an experiment with Inositol (using the Jarrow powder). I know that those studies from the late 1990s showed promising results at 12-18 grams. And the conditions for which Inositol in those studies was used do seem to match my symptoms--ruminating GAD, PTSD, with obsessive worrying tendencies. But I got scared because 12-18 grams is so much to take and I really need to know that what I am putting in my body is completely safe if I'm going to take five heaping teaspoons a day! Anyway, I definitely did not give Inositol at high doses a sufficient trial. Have you tried it? Did you notice anything positive? I'd be willing to take Inositol in high doses if I knew it was completely safe and the stuff I was putting in my body was free of contaminants.
Posted by mogger on January 15, 2014, at 16:42:46
In reply to Re: Recent study on Prozac: Theracumin? » mogger, posted by Chris O on January 15, 2014, at 16:12:45
Chris,
I have been taking 18 grams (3 tablespoons) of inositol for 7 years a day and it is very helpful. Motivation, energy, depression and anxiety has improved. It is taken from rice in jarrow's case from Japan. Swanson vitamins takes their inositol from soy. It is the first supplement other than high doses of EPA from fish oil that my doctor at UCLA put me on. Both jarrow and swanson are GMP and my doctor says he is comfortable with his patients taking it long term. I hear you about being concerned about contaminants but I trust both brands and I do believe that at a certain point one must just goffor it. We could be hit by a bus this evening so I think it is important to try and set aside these concerns and try it anyway. I get check ups 2 times a year and I am in good physical health. The benefits outweigh the costs.
Posted by Chris O on January 15, 2014, at 17:01:02
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 16:42:46
Mogger:
Hey, thanks for that, man. That's awesome that it is working so well for you. Makes me really want to try it again. Need to find a brand I'm comfortable taking, I guess.
NOW Foods just wrote me back. Their Inositol country of origin is China. Yeah, well, that's not too promising for me. At least they told me the truth. And NOW Foods said they test it for contaminants in their "advanced in-house labs," but my eyes have seen too much to trust that. It's probably fine, but I just can't put any product into my body from the monstrosity that is the Chinese manufacturing industry.
As for Japan I know that this is just evidence of my paranoid, but what about radiation from the nuclear disaster there? Is that a concern with any of these supplements? Your doctor would probably say no, and it's also probably not of concern, but it still worries me.
Thanks,
Chris
Posted by mogger on January 15, 2014, at 19:13:50
In reply to Re: Recent study on Prozac: Theracumin?, posted by Chris O on January 15, 2014, at 17:01:02
They are not taking the inositol from rice near Fukushima as that is blocked off to farming. Actually Jarrow's inositol is now non GMO.
Posted by Chris O on January 16, 2014, at 1:35:22
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 19:13:50
Mogger:
That's interesting to know. Can you tell me what you experienced with the Inositol? How does it affect you, specifically?
Thanks,
Chris
Posted by Chris O on January 16, 2014, at 13:03:16
In reply to Re: Recent study on Prozac: Theracumin? » Chris O, posted by mogger on January 15, 2014, at 19:13:50
Mogger:
So, just out of curiosity, I wrote some of the companies producing Inositol yesterday to find out where they manufactured their product. From Swanson, I received this lovely reply (hey, at least they are honest!):
"Dear Valued Customer,
Thank you for contacting Swanson Health Products!
Upon speaking with one of our Products Specialists here at Swanson's they said that we do not know where it was made. Unfortunately, we are not always given the information of where our manufactor makes our products and this was one of those situations. We are sorry we do not have that information. Please let us know if you have any further questions!"Yes, that's right. Swanson does not know where its Inositol powder is made! Well, that's comforting! (And I'm pretty certain the person who wrote that reply is not a native English speaker.) Love being stuck between the hapless, "side-effect" filled pharmaceutical industry and the predatory, lawless "supplement" industry. Oh, isn't global capitalism grand!
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Dr. Bob is Robert Hsiung, MD,
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