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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Ben on September 26, 2011, at 3:05:19
I take 80 mg of Parnate and 50 mg of Doxepin. ith the Parnate I had no weight gain but since I added Doxepin my weight has gone up. I read that MAOIs and TCAs potentiate weight gain. Whats your experience?
Posted by SLS on September 26, 2011, at 8:54:31
In reply to Parnate and Doxepin --) weight gain, posted by Ben on September 26, 2011, at 3:05:19
> I take 80 mg of Parnate and 50 mg of Doxepin. ith the Parnate I had no weight gain but since I added Doxepin my weight has gone up. I read that MAOIs and TCAs potentiate weight gain. Whats your experience?
I can almost guarantee that if you combine Parnate with desipramine, you will lose weight.
- Scott
Posted by Phillipa on September 26, 2011, at 10:47:09
In reply to Re: Parnate and Doxepin --) weight gain » Ben, posted by SLS on September 26, 2011, at 8:54:31
Scott seriously lose weight on a TCA? Why is this? Phillipa
Posted by jono_in_adelaide on September 26, 2011, at 17:00:48
In reply to Re: Parnate and Doxepin --) weight gain » SLS, posted by Phillipa on September 26, 2011, at 10:47:09
The weight gain is related to the antihistaminic/sedative activity of there TCA's, doxepin has extremely high antihistaminic activity, so lots of weight gain, desipramine has almost none, so little weight gain (but it wont help you sleep though)
Posted by creepy on September 27, 2011, at 4:07:00
In reply to Re: Parnate and Doxepin --) weight gain » SLS, posted by Phillipa on September 26, 2011, at 10:47:09
desipramine is all NE reuptake. Doesnt really work on much else.
I got a little tachycardia and heartburn on it, but it was pretty good on energy and depression.
I really dont think weight gain is common on that, despite what the PI sheet says.
You might get a little physical anxiety on it, thats about the only real downside.
Posted by Ben on September 27, 2011, at 4:46:15
In reply to Re: Parnate and Doxepin --) weight gain, posted by creepy on September 27, 2011, at 4:07:00
Do you think Doxepin causes weight gain at doses from 10 to 25mg/d. I would like to take it at bedtime to sleep. I read that MAOis does potentiate the weight gain of TCAs.
Posted by SLS on September 27, 2011, at 6:15:51
In reply to Re: Parnate and Doxepin --) weight gain, posted by Ben on September 27, 2011, at 4:46:15
> Do you think Doxepin causes weight gain at doses from 10 to 25mg/d. I would like to take it at bedtime to sleep. I read that MAOis does potentiate the weight gain of TCAs.
I think the relationship is additive rather than synergistic. I don't think it is a true potentiation of effect.
If you need something for sleep, what alternatives has your doctor presented you with?
- Scott
Posted by Ben on September 27, 2011, at 6:22:21
In reply to Re: Parnate and Doxepin --) weight gain, posted by SLS on September 27, 2011, at 6:15:51
Benzodiazepines, Zolpidem CR, Zopiclon etc. The problem is that Doxepin helps my depression and for my nervousness.
Posted by SLS on September 27, 2011, at 7:00:55
In reply to Re: Parnate and Doxepin --) weight gain, posted by Ben on September 27, 2011, at 6:22:21
> Benzodiazepines, Zolpidem CR, Zopiclon etc. The problem is that Doxepin helps my depression and for my nervousness.
Nortriptyline might be just as effective as an antidepressant. Anxiety very is often co-morbid with depression. In these cases, the anxiety subsides as the depression dissipates. Weight gain with nortriptyline is, at most, moderate. For me, it doesn't seem to contribute to my increases in body weight. Abilify and Nardil did that. When I discontinued nortriptyline for awhile as an experiment, there was no reduction in weight.
Desipramine is an alternative, but it might exacerbate anxiety and insomnia a bit at first. It should not produce any weight gain.
- Scott
Posted by Ben on September 27, 2011, at 7:05:39
In reply to Re: Parnate and Doxepin --) weight gain » Ben, posted by SLS on September 27, 2011, at 7:00:55
Thanks a lot. I am on Abilfy too. Desipramine isn't available where I life. Isn't Nortyptilin activating? Concerning the Abilify I think I got more anxious and have more tremor as from the lithium alone. Whats your experience?
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