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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by NKP on April 20, 2011, at 13:41:08
According to Wikipedia:
"Flupentixol acts as an antagonist at various dopamine (D1-D5), serotonin (5-HT2), adrenaline (α1), and histamine (H1) receptors, without affecting the muscarinic acetylcholine receptors.
Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation."
(http://en.wikipedia.org/wiki/Fluanxol)
Since Fluanxol blocks the dopamine autoreceptor at lower doses, would this lessen the risk of tardive dysknesia?
Posted by Christ_empowered on April 20, 2011, at 14:52:59
In reply to Fluanxol, tardive dyskinesia, posted by NKP on April 20, 2011, at 13:41:08
Hey. I'd be kind of afraid to take Fluanxol, too, but from what I've read, acute EPS and TD are both fairly infrequent with the doses used for depression. I imagine that if you get acute EPS off the first few doses that would be a warning sign; you might then want to switch to a low dose atypical, or avoid neuroleptics altogether.
TD risk goes up as dose and length of treatment go up, so low doses of any antipsychotic are preferable to standard or high doses in terms of TD risk, especially if you're going with an older, conventional antipsychotic.
Do doctors in your area prescribe the Fluanxol alone to treat problems, or do they use it as an add-on to other things?
Posted by NKP on April 22, 2011, at 1:36:11
In reply to Re: Fluanxol, tardive dyskinesia, posted by Christ_empowered on April 20, 2011, at 14:52:59
> Hey. I'd be kind of afraid to take Fluanxol, too, but from what I've read, acute EPS and TD are both fairly infrequent with the doses used for depression. I imagine that if you get acute EPS off the first few doses that would be a warning sign; you might then want to switch to a low dose atypical, or avoid neuroleptics altogether.
>
> TD risk goes up as dose and length of treatment go up, so low doses of any antipsychotic are preferable to standard or high doses in terms of TD risk, especially if you're going with an older, conventional antipsychotic.
>
> Do doctors in your area prescribe the Fluanxol alone to treat problems, or do they use it as an add-on to other things?I am taking 0.5 mg / day Fluanxol and 50 mg / day Zoloft. I feel I am benefiting from the Fluanxol and I do not want to stop using it.
Something which I have noticed, although I think it may be the Zoloft which is responsible, because in the past, when using Zoloft, Cymbalta, and Wellbutrin, the same thing happened, is that I keep compulsively jerking, tensing and relaxing the muscles in my legs and arms, especially around my knees and elbows. It seems worse in the mornings and evenings. It is not involuntary though, I can control it. Is this what they mean by akathisia or hyperkinesia?
Factors which I think make it less likely I will develop TD:
* I am using a very low dose of Fluanxol.
* I am a man.
* I don't drink or smoke.
* I don't have any brain trauma.
* I take 400 IU vitamin E daily.
* I am taking Zoloft at the same time.Factors which I think make it more likely I will develop TD:
* Fluanxol is a high potency typical neuroleptic.
* I plan on using Fluanxol long-term.
* I have depression, and TD is more common with affective disorders than with psychoses.
* By the nature of my work, I sometimes get too little sleep during the week, and this places stress on my brain.
* The muscle jerks in my legs and arms may suggest a predisposition towards TD.
This is the end of the thread.
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