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Dr. Bob is Robert Hsiung, MD,
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Posted by Zana on March 26, 2009, at 15:13:00
In reply to Re: Agomelatine, posted by Niltiac on March 25, 2009, at 12:19:44
What is agomelatin? I can't find it listing on my RX sites.
Thanx
Zana
Posted by Negcreep on March 30, 2009, at 7:58:05
In reply to Re: Agomelatine, posted by Niltiac on March 25, 2009, at 12:19:44
I'm living in the UK and a sufferer of GAD too. I also work in a university in an academic environment so can completely sympathise! Agomelatine has helped me a lot.
All I can say is to visit our group and you will be pleasantly surprised.See you there
Negcreep :)
Posted by Michael Bell on April 3, 2009, at 20:18:37
In reply to Agomelatine, posted by Bob12 on February 28, 2009, at 11:01:05
I am just wondering what effect, if any, agomelatine has on social anxiety?
Posted by Sigismund on April 3, 2009, at 23:13:43
In reply to Re: Agomelatine - what effect on socialization?, posted by Michael Bell on April 3, 2009, at 20:18:37
>what effect, if any, agomelatine has on social anxiety?
Agomelatine does not jack my mood up as such, but it does make me feel more resilient, and therefore is useful for social anxiety, but not at all like disinhibiting agents.
Posted by bearfan on July 8, 2009, at 16:52:29
In reply to Re: Agomelatine - what effect on socialization? » Michael Bell, posted by Sigismund on April 3, 2009, at 23:13:43
When will Agomelatine be released in the U.S.? I heard its Phase III trials, and no further trial applicants are being accepted. Can you buy this online overseas like similar unavailable medicines?
Posted by bearfan on July 17, 2009, at 13:58:08
In reply to Agomelatine, posted by Bob12 on February 28, 2009, at 11:01:05
I was kind of curious on how this compares with Lexapro on GAD? I thought Lexapro was effective for GAD, but it wasn't really activating in making me really have the motivation to change my life; plus there was a dopey effect. Possibly Agomelatine is better in that regard?
Posted by Negcreep on July 27, 2009, at 2:48:21
In reply to Re: Agomelatine, posted by bearfan on July 17, 2009, at 13:58:08
Its not quite as powerful an effect as lexapro (for me anyway), and positive mood is not changed so significantly. But it does make a difference and the lasck of side effcts is a bonus.
Posted by allanpommer on October 25, 2010, at 22:05:33
In reply to Re: Agomelatine » Bob12, posted by Maria3667 on March 2, 2009, at 16:00:03
I found intersting to share my experience with this new medication Agomelatine, well i was expecting it for long time now after march of 2010 we have it available in brasil, well i have tried lots of diferents medicines, first i was for 6 years having paroxetine 20mg once a day, well the first year i got so sleepy and mindless, start waking up late after 11 a.m. lost my job and had to face new way to deal with my own condition, till i get in deep depression, so, doctors try new medicines, until i gave up last year, when i stopped taking antedepressants, now i just started a 7 days ago the agomelatine 25mg, I dint stop my sleeping pills in fist day of agomelatine, but after 4 days im not taking sleeping pills along with agomelatine, it seams that my sleep conditions have improved, i wake up better and i feel better with just 7 days, apart from my sleepy, I can say im more calm then a week ago, specialy in traffic when i used to be so anxious. now and then i hope i get even better but id like to share whats happening in my life with agomelatine.
Allan Pommer
Posted by ggggg123 on October 28, 2010, at 2:59:23
In reply to Re: Agomelatine, posted by allanpommer on October 25, 2010, at 22:05:33
What are people's experiences from ago? anyone been on this med for a while? is it good for anhedonia? I see it mainly affects melatonin, which is good for sleep but it also indirectly raises norepinephrine and dopamine but not serotonin, hopefully meaning ago would be good for anhedonia and have a positive afect on sexual functioning, also it is made by servier, possibly to make up for the rejection of aminetpine? thanks.
Posted by Ernie D. on October 29, 2010, at 23:24:46
In reply to Re: Agomelatine, posted by ggggg123 on October 28, 2010, at 2:59:23
I've been taking Ago for 9 months now at 12.5mg per night for GAD. The 25mg dose gives me pain in my legs. I'm not sure what this med is doing if anything at all. Nothing will ever touch the benefits that Aminetpine(Survector) produces.
Posted by Ron Hill on October 30, 2010, at 18:32:02
In reply to Agomelatine, posted by Bob12 on February 28, 2009, at 11:01:05
> Hi,
> Can anyone describe their experiences with Agomelatine?
> thanks
> Bob
-------------------------
I've been taking Valdoxan (agomelatine) for more than three months and it has stopped my bipolar ultra rapid cycling.See the following post for more information:
http://www.dr-bob.org/babble/20101020/msgs/966675.html
-- Ron
Posted by ggggg123 on October 31, 2010, at 10:28:11
In reply to Re: Agomelatine, posted by Ernie D. on October 29, 2010, at 23:24:46
I have never tried amineptine, but I hear it was the only good ad, especially for people with anhedonia/dopamine deficient depression. It was also made by servier like agomelatine is, shame its been banned, its still available on the net but ridiculously expensive. So you are'nt getting much benefit from the valdoxan, what about adding another agent? something dopaminergic?
Posted by Ernie D. on October 31, 2010, at 21:17:27
In reply to Re: Agomelatine, posted by ggggg123 on October 31, 2010, at 10:28:11
> I have never tried amineptine, but I hear it was the only good ad, especially for people with anhedonia/dopamine deficient depression. It was also made by servier like agomelatine is, shame its been banned, its still available on the net but ridiculously expensive. So you are'nt getting much benefit from the valdoxan, what about adding another agent? something dopaminergic?
I am going to drop the Ago and replace it with Mebicar (Adaptol).
Posted by ggggg123 on November 2, 2010, at 12:58:00
In reply to Re: Agomelatine, posted by Ernie D. on October 31, 2010, at 21:17:27
Sounds good for anxiety, it can't be as bad as western medicine.
Posted by SLS on November 2, 2010, at 16:02:22
In reply to Re: Agomelatine » Ernie D., posted by ggggg123 on November 2, 2010, at 12:58:00
I have just discontinued taking agomelatine. I responded quite well to it for a few days during week 2. However, I experienced no improvement thereafter. I would have stayed on it longer, but it made me feel more depressed. I guess I could rechallenge my system by restarting agomelatine, but I'm in no mood to feel worse again.
Interestingly, I reacted to agomelatine by experiencing an improvement in depression for a few days beginning the day after my first h.s. dose. Unfortunately, it didn't last. When I responded to agomelatine again 10 days later, I was convinced that I was going to attain a long-term remission. I was just about ready to drop another $600 on the stuff.
- Scott
Posted by sigismund on November 3, 2010, at 16:16:14
In reply to Re: Agomelatine, posted by SLS on November 2, 2010, at 16:02:22
>I was just about ready to drop another $600 on the stuff.
Goodness! You haven't been on it long.
How much do you have to pay for it (if you don't mind me asking)?
It's not super expensive in the US like other meds, is it?
Posted by SLS on November 3, 2010, at 16:36:19
In reply to Re: Agomelatine » SLS, posted by sigismund on November 3, 2010, at 16:16:14
> >I was just about ready to drop another $600 on the stuff.
>
> Goodness! You haven't been on it long.
>
> How much do you have to pay for it (if you don't mind me asking)?
>
> It's not super expensive in the US like other meds, is it?
I try to be patient with allowing medication sufficient time to work. However, this stuff was making me feel like crap. I stopped taking it after only 3 weeks. The bottom line is that my brain sucks.I found that agomelatine costs about $100 for a 28 day supply at 25mg/day. By US standards, this is relatively inexpensive. I was so convinced that my response to agomelatine would continue, that I was ready to start hoarding the stuff.
I am really undecided whether or not to restart agomelatine. I think I have exhausted all of what US psychopharmacology has to offer, and I am all out of ideas. I guess it makes sense to rechallenge myself with agomelatine to see if I react badly to it again.
I hope you are doing well.
- Scott
Posted by ed_uk2010 on November 3, 2010, at 16:49:02
In reply to Re: Agomelatine » sigismund, posted by SLS on November 3, 2010, at 16:36:19
>I think I have exhausted all of what US psychopharmacology has to offer, and I am all out of ideas.
Have you tried tianeptine yet? I don't recall.
Posted by Ron Hill on November 3, 2010, at 18:16:17
In reply to Re: Agomelatine » sigismund, posted by SLS on November 3, 2010, at 16:36:19
Scott,
Warning: Tongue in cheek below:
> I was so convinced that my response to agomelatine would continue, that I was ready to start hoarding the stuff.
HOARDING? They have a saying in the stock market; Bulls make money, Bears make money, but Pigs get slaughtered!
Correct me if I'm wrong, but I don't think you meant "hoarding". Instead, I think you meant that you were going to buy in bulk in order to lower your cost, and replenish your supply. And, at the same time, you would have been staying within the U.S FDA rules for purchasing medication off-shore.
Since Valdoxan quit working for you, I'm delighted that you did not pay $600 bucks to hoard, (oops, I mean restock) by buying another three months supply.
Always remember, Pigs get slaughtered. And, that's not kosher.
-- Ron
Posted by ggggg123 on November 3, 2010, at 19:50:09
In reply to Re: Agomelatine » SLS, posted by ed_uk2010 on November 3, 2010, at 16:49:02
what are your depressive symptoms?
I think physical exercise for at least an hour a day is about 80% and meds 20%.
Have you tried the tri's and the maois?
theres a new treatment called vagus nerve stimulation, it sounds sick, but seems to be helping people, its like having a pacemaker for depression lol.
Posted by sigismund on November 4, 2010, at 18:46:38
In reply to Re: Agomelatine » sigismund, posted by SLS on November 3, 2010, at 16:36:19
Yeah, I'm fine Scott :)
>I found that agomelatine costs about $100 for a 28 day supply at 25mg/day. By US standards, this is relatively inexpensive.
I imagine it is.
They say it will be on sale here now almost for around $60.
Posted by Bob on November 9, 2010, at 16:20:36
In reply to Re: Agomelatine » sigismund, posted by SLS on November 3, 2010, at 16:36:19
>
>
> I try to be patient with allowing medication sufficient time to work. However, this stuff was making me feel like crap. I stopped taking it after only 3 weeks. The bottom line is that my brain sucks.
>
> I found that agomelatine costs about $100 for a 28 day supply at 25mg/day. By US standards, this is relatively inexpensive. I was so convinced that my response to agomelatine would continue, that I was ready to start hoarding the stuff.
>
> I am really undecided whether or not to restart agomelatine. I think I have exhausted all of what US psychopharmacology has to offer, and I am all out of ideas. I guess it makes sense to rechallenge myself with agomelatine to see if I react badly to it again.
>
> I hope you are doing well.
>
>
> - Scott
>
Well, if your brain is crap, I don't know where that leaves me. I get very little therapeutic benefit from the meds, and I can only tolerate a fraction of what you can.Bob
P.S. Have you entertained something like rTMS, or DBS? I think I remember you saying you had ECT, right?
Posted by SLS on November 9, 2010, at 16:59:48
In reply to Re: Agomelatine » SLS, posted by Bob on November 9, 2010, at 16:20:36
>
> >
> >
> > I try to be patient with allowing medication sufficient time to work. However, this stuff was making me feel like crap. I stopped taking it after only 3 weeks. The bottom line is that my brain sucks.
> >
> > I found that agomelatine costs about $100 for a 28 day supply at 25mg/day. By US standards, this is relatively inexpensive. I was so convinced that my response to agomelatine would continue, that I was ready to start hoarding the stuff.
> >
> > I am really undecided whether or not to restart agomelatine. I think I have exhausted all of what US psychopharmacology has to offer, and I am all out of ideas. I guess it makes sense to rechallenge myself with agomelatine to see if I react badly to it again.
> >
> > I hope you are doing well.
> >
> >
> > - Scott
> >
>
>
> Well, if your brain is crap, I don't know where that leaves me. I get very little therapeutic benefit from the meds, and I can only tolerate a fraction of what you can.
>
> Bob
>
> P.S. Have you entertained something like rTMS, or DBS? I think I remember you saying you had ECT, right?
I feel that I am incredibly fortunate that people like you should remember such things about me and my illness. Thanks.I would do rTMS tomorrow if I were able to afford it. It costs $8000 for the initial series of treatments. Each maintenance treatment thereafter is $400. My hope is that Medicare will eventually cover it, as it seems that evidence is accumulated that it can be effective for TRD.
Be well.
- Scott
Posted by Bob on November 10, 2010, at 15:38:50
In reply to Re: Agomelatine » Bob, posted by SLS on November 9, 2010, at 16:59:48
> >
> > >
> > >
> > > I try to be patient with allowing medication sufficient time to work. However, this stuff was making me feel like crap. I stopped taking it after only 3 weeks. The bottom line is that my brain sucks.
> > >
> > > I found that agomelatine costs about $100 for a 28 day supply at 25mg/day. By US standards, this is relatively inexpensive. I was so convinced that my response to agomelatine would continue, that I was ready to start hoarding the stuff.
> > >
> > > I am really undecided whether or not to restart agomelatine. I think I have exhausted all of what US psychopharmacology has to offer, and I am all out of ideas. I guess it makes sense to rechallenge myself with agomelatine to see if I react badly to it again.
> > >
> > > I hope you are doing well.
> > >
> > >
> > > - Scott
> > >
> >
> >
> > Well, if your brain is crap, I don't know where that leaves me. I get very little therapeutic benefit from the meds, and I can only tolerate a fraction of what you can.
> >
> > Bob
> >
> > P.S. Have you entertained something like rTMS, or DBS? I think I remember you saying you had ECT, right?
>
>
> I feel that I am incredibly fortunate that people like you should remember such things about me and my illness. Thanks.
>
> I would do rTMS tomorrow if I were able to afford it. It costs $8000 for the initial series of treatments. Each maintenance treatment thereafter is $400. My hope is that Medicare will eventually cover it, as it seems that evidence is accumulated that it can be effective for TRD.
>
> Be well.
>
>
> - Scott
>
>
Yeah, I hear you... it is real, real expensive.I guess you are not entertaining being in any studies or the like?
Posted by SLS on November 10, 2010, at 17:21:39
In reply to Re: Agomelatine » SLS, posted by Bob on November 10, 2010, at 15:38:50
> I guess you are not entertaining being in any studies or the like?
Not really.
I would hate to subject myself to 4 weeks of sham treatments.
- Scott
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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