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Dr. Bob is Robert Hsiung, MD,
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Posted by bleauberry on August 19, 2010, at 18:36:16
In reply to Re: Marijuana as a Medication in Depress and Anxiety » bleauberry, posted by SLS on August 18, 2010, at 21:09:33
> > In longterm chronic use, I think the Indica strains have a very low likelihood of causing schizo-like problems. The Sativas are much more risky.
>
> How are the two strains different?
>
>
> - ScottIndicas are benzo-like, Sativas are stimulant-like.
Most strains are hybrid blends of varying percentages.
Posted by bleauberry on August 19, 2010, at 18:44:30
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 18, 2010, at 21:35:04
Thanks for sharing the posts on the studies.
I found the following line particularly interesting:
" It is also notable that some research suggests that alcohol abuse is a stronger predictor of psychotic symptoms than regular cannabis use (by a factor of four)."
Four times worse? Wow. But it's legal. Ok.
I think it is easy to accidentally get distracted off the subject in studies like those.
On one hand we are talking about medicinal use of mJ which is a completely different ballgame than teenage chronic abuse of mj. The abusers are smoking a bunch of it when they don't need it, abusing it.
The patients are smoking small controlled doses for specific benefits, getting high not being one of them.
The studies only looked at the abusers, not patients. The smoking habits of each of those two groups are completely different.
Posted by morgan miller on August 19, 2010, at 22:30:01
In reply to Re: Marijuana as a Medication in Depress and Anxiety » morgan miller, posted by bleauberry on August 19, 2010, at 18:44:30
>I found the following line particularly interesting:
>" It is also notable that some research suggests that alcohol abuse is a stronger predictor of psychotic symptoms than regular cannabis use (by a factor of four)."
>Four times worse? Wow. But it's legal. Ok.
Ha ha, yeah alcohol is bad news, much worse that MJ in many ways. I have to admit though that alcohol is still my preferred drug of choice.
>On one hand we are talking about medicinal use of mJ which is a completely different ballgame than teenage chronic abuse of mj. The abusers are smoking a bunch of it when they don't need it, abusing it.
Yep..Also, while the brain is still developing at such young ages, drug abuse is more likely to have a greater negative impact.
Posted by Zyprexa on August 19, 2010, at 23:35:05
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 18, 2010, at 21:35:04
After reading that.. I think that mj made me schizo. My first couple of times smoking mj, were very psychotic and incapasitating. My first time I lay on a bed unable to get up for several hours (2 maybe), second time I smoked and hit the floor right after smoking. When I finaly got up, my thinking was realy messed up and I didn't see life in a way that made sense, almost like a dream. Anouther time after that I would smoke and pass out. This has happened a lot, where I could not function and would be incapasitated for some time. On the other hand there were many times I could function just fine after a smoke, usualy when I was use to it. I smoked pretty much non stop for a bunch of years when I felt fine on it. Maybe it was different strains or lacing. But ya I think I was psychotic on mj for a number of years at times. I have heard that my diagnosis was mj depression. And thinking back in time I think mj may have made me psychotic at times.
I will say that alcohol never did any of this to me. Usualy (right from the beginning) alcohol was always a lift in mood and never have I heard any voicis more on alcohol more than sober.
Posted by Zyprexa on August 19, 2010, at 23:48:05
In reply to Re: Marijuana as a Medication in Depress and Anxiety » morgan miller, posted by bleauberry on August 19, 2010, at 18:44:30
I will say I always did better with small doses.
Posted by linkadge on August 20, 2010, at 8:29:08
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 17, 2010, at 20:15:08
>Many things are not conclusive, but there is >evidence. If you are genetically predisposed or >possibly genetically predisposed to >schizophrenia, why risk it?
Pretty much all there is are correlational studies. Schizophrenia is also "correlated" with high tobacco use, for instance. For a while they were suggesting that the tobacco exaserbated (or even caused) schizophrenia in "succeptable" people.
On the contrary they are finding mechanisms by which nicotine improves schizophrenic symptoms. It increases gaba levels in the schizophrenic brain and also appears to improve cognition and anxiety levels. Newer studies suggest that schizophrenics who smoke tobacco have a better long term prognosis than those who don't.
It all depends on how the study is conducted and what the researchers are trying to prove.
Newer researchers have tried to look for mechanisms by which marijaunna might actually be used theraputically for schizophrenia.
It has been known for a while that there is high overlap of bipolar disorder and schizophrenia. Many of the medications used for either illness are interchangeable. Some cases of schizophrenia are often misdiagnosed as bipolar. There are many bipolar patients who claim that marijuanna acts as a mood stabilizer for them - calming both the highs and the lows. By the same tolken, it could have theraputic utility in schizophrenia.
Some researchers have found greatly diminished levels of anandamide in the schizophrenic brain. They propose that schizophrenics smoke to replace the cannabanoid receptor activation that would be given by the missing anandamide.
Of course, if you don't need to smoke it..don't. But, if for some reason it works for you, I wouldn't be thrown off by a unproven potential ill effect.
Linkadge
Posted by linkadge on August 20, 2010, at 8:47:15
In reply to Re: Marijuana as a Medication in Depress and Anxiety » bleauberry, posted by Zyprexa on August 19, 2010, at 23:48:05
Correlation does not imply causation. That an individual was diagnosed with schizophrenia after marijuanna use does not prove that marijuanna caused the schizophrenia.
I smoked something once that made me feel very "off". I later learned that it was MJ laced with ketamine. I never had the same experience before or since.
Thats the problem with stuff on the street. You get all these case reports that are essentially meaningless because the same agent is not being tested.
Also, short term drug effects don't correlate with the symptoms of a disease. Enough amphetamine can cause mania in just about anyone.
If somebody has a manic episode on amphetamine, does it mean they have bipolar disorder? If a bipolar individual has their first manic episode on amphetamine, does it mean that the amphetamine caused bipolar?
Antidepressants have been linked to earlier onset of bipolar disorder in those with genetic susceptability to bipolar. That being said, we don't ban the use of antidepressnts for this reason.
I remember reading how, schizophrenics tend to use MJ in a very particular dose range. One that increases prefrontal dopaminergic neurotransmission without significantly affecting limbic dopamine neurotransmission. I.e. to reduce negative symptoms, not to get high.
Linkadge
Posted by morgan miller on August 20, 2010, at 15:39:24
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by linkadge on August 20, 2010, at 8:47:15
Hey Link, I think the primary concern over marijuana and schizophrenia is the abuse of marijuana by young teens increasing the chance of developing the illness. I don't think we can deny the fact that marijuana abuse or any drug abuse during early adolescence may carry the risk of damaging the brain and disrupting it's development in a way that increases the chance of developing any type of mental illness. A developing brain is especially susceptible to the effect of mind altering substances.
Posted by Phillipa on August 20, 2010, at 19:34:43
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by linkadge on August 20, 2010, at 8:29:08
Link when working in psych smoking was pretty much necessary for scizophrenics my favorite patients. But they were talking the docs that is that the tobacco increased dopamine levels? Any truth or was it disproved? Phillipa
Posted by Zyprexa on August 20, 2010, at 22:40:14
In reply to Re: Marijuana as a Medication in Depress and Anxiety » linkadge, posted by Phillipa on August 20, 2010, at 19:34:43
Its true Phillipa, smoking releases dopamine. Also I've read that nicotine is theraputic to schitzophrenics. Does not have to be tobaco.
Posted by linkadge on August 21, 2010, at 10:16:01
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 20, 2010, at 15:39:24
I agree with you that marijuanna use in teens is cause for concern.
But, why are teens using MJ in the first place? Some are using it for depression and or anxiety.
If marijuanna use was to abruptly be terminated, there would arguably be more teens on psychiatric medications. Some would suggest this is a better route, but is it really?
One argument against the use of MJ in teens is that it causes amotivational syndrome. But, are SSRIs any better in this regard?
At least on MJ I could sleep. Apathy plus insomnia is worse than pure apathy. Besides, MJ apathy was more tollerable than paxil apathy. MJ didn't give me akathesia, make me want to slash my wrists, or ram an icepick through my skull.
**How about developing treatments for depression, anxiety and schizophrenia that actually work well in teens**, and then start telling teens to stop their MJ crutch.
Linkadge
Posted by violette on August 21, 2010, at 11:13:43
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by linkadge on August 20, 2010, at 8:29:08
Linkadge-
Thanks for your posts in this thread...very informative.
"**How about developing treatments for depression, anxiety and schizophrenia that actually work well in teens**, and then start telling teens to stop their MJ crutch."
That's how I feel too. (BTW-I hate MJ as it made me anxious when I tried it).
"On the contrary they are finding mechanisms by which nicotine improves schizophrenic symptoms. It increases gaba levels in the schizophrenic brain and also appears to improve cognition and anxiety levels."
I recently read approximately 90% (maybe from one study in the past?) of schizophrenics smoke cigarettes.
Can you please tell me if there are other ways of 'increasing' gaba levels in the brain (aside from meds and nicotine)? I think I have some of the schizo genes and would like to experiment with anything, if available, other than those 2 substances. Thanks. :)
Posted by islan on August 21, 2010, at 18:11:07
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by linkadge on August 20, 2010, at 8:29:08
>> "There are many bipolar patients who claim that marijuanna acts as a mood stabilizer for them - calming both the highs and the lows."
Yep, check out this link:
http://www.ukcia.org/research/TheUseofCannabisasaMoodStabilizerinBipolarDisorder.phpI have been using cannabis regularly for four years. I find it helps me tame my angry and irritable moods, and also to pull me out of apathy and despair so that I can smile and feel grateful. It helps stop my mind from racing and generally helps me feel cheerful. I worry that in the long term it may be contributing to my anxiety (only because people say it makes users paranoid, not because of any personal experiences), but in the short term, it's often what gets me through the day, helps me stop crying, and lets me relax.
Posted by morgan miller on August 21, 2010, at 18:18:52
In reply to Re: Marijuana as a Medication in Depress and Anxiety » morgan miller, posted by linkadge on August 21, 2010, at 10:16:01
>But, why are teens using MJ in the first place? Some are using it for depression and or anxiety.
I think this is where we need a revolution in parenting and mental health to take place. The only way that is going to happen is for people to have an awareness of how their parents and childhood had a lasting effect on them, then take whatever measures necessary to nurture themselves closer to where they would have been if they had most of what they needed growing up(therapy, constant self refection and introspection, parenting clasees, yes, parenting classes). I know, easier said than done.
>If marijuanna use was to abruptly be terminated, there would arguably be more teens on psychiatric medications. Some would suggest this is a better route, but is it really?
I do not like the idea of giving teens and especially pre-teen children psychiatric medications. I believe the too carry the risk of interfering with healthy brain development. Like I mentioned above, we need to start focusing on the reasons why children are using drugs like marijuana and try to work on resolving that issue. I compare it to the war on drugs, we spend so much time trying to fight the people selling drugs instead of educating the masses on why people are using drugs(and it is NOT just because they are genetically predisposed to addiction, it never is, I'm afraid things just aren't that simple) and try to come up with ways to empower people with solutions on getting better. Of course these long term solutions would require actually dealing with some fairly uncomfortable issues and take a whole lot of effort and time. Usually the real solution is the one that is most difficult and takes the most time.
>One argument against the use of MJ in teens is that it causes amotivational syndrome. But, are SSRIs any better in this regard?
My personal experience with SSRIs has not been one of feeling less motivated, but I have seen so many people do worse in school and lose motivation to do productive healthy things when using marijuana. The problem with teens is they are not likely to control the use of marijuana to a point where it would be therapeutic and not destructive.
>**How about developing treatments for depression, anxiety and schizophrenia that actually work well in teens**, and then start telling teens to stop their MJ crutch.
Yes! And the rest of us grown adults will want those treatments too! Hopefully sooner than later medications will be developed that are not as invasive and may actually be good for our brains.
Linkage
Posted by morgan miller on August 21, 2010, at 18:58:17
In reply to Re: Marijuana as a Medication in Depress and Anxiety » linkadge, posted by violette on August 21, 2010, at 11:13:43
I also still believe it is possible that MJ use/abuse may make teens and others feel better for a while, but worsen conditions of depression later, especially when coming off MJ. And, MJ feels, at least to me(and I know to friends that used it a lot in the past) too much like an escape from reality. SSRIs gave me a bit of this feeling, but nothing like MJ.
> Can you please tell me if there are other ways of 'increasing' gaba levels in the brain (aside from meds and nicotine)? I think I have some of the schizo genes and would like to experiment with anything, if available, other than those 2 substances. Thanks. :)
Would you be willing to try a nicotine patch? Or, are you trying to avoid nicotine all together?
There are several natural substances that come to mind with regards to boosting GABA levels:Magnesium-glycinate or taurinate-improves function of several neurotransmitters, including GABA
Taurine-inhibitory neurotransmitter amino acid
GABA-gamma-aminobutyric acid-inhibitory neurotransmitter
L Glutamine-inhibitory neurotransmitter-precursor to GABA
Ashwagandha-adaptogen-adaptogen-strong antioxidant power-may improve thyroid functionGlycine-inhibitory neurotransmitter-does not necessarily boost GABA but does have a calming effect and has been found to possibly be effective in treating symptoms of schizophrenia-protects against glutamate exitotoxicity through inhibiting NMDA receptors-I think?!
Most inhibitory neurotransmitter amino acids need to be taken with B6(p5p may be the best form) to improve absorption/metabolism.
Morgan
Posted by emmanuel98 on August 21, 2010, at 18:58:25
In reply to Re: Marijuana as a Medication in Depress and Anxiety » linkadge, posted by morgan miller on August 21, 2010, at 18:18:52
Not all teens who use marijauna are self-medicating mental illness. My daughter, who is as mentally healthy as they come, smokes sometimes just for fun. It feels good. It's fun to do with other young adults because it makes people laugh and feel silly. I used to enjoy (years ago, when I was in my twenties) smoking with my husband and watching B movies and laughing and laughing. Not everyone who uses drugs and alcohol use them addictively.
Posted by morgan miller on August 21, 2010, at 19:49:39
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by emmanuel98 on August 21, 2010, at 18:58:25
>Not all teens who use marijauna are self-medicating mental illness. My daughter, who is as mentally healthy as they come, smokes sometimes just for fun.
Right, sometimes and just for fun. I'm talking about teens that abuse it and use it all of the time and daily. That's the difference between self medicating and simply using recreationally. Using marijuana occasionally is typical of teen experimentation, as its alcohol use.
Posted by weatherfreak on August 25, 2010, at 4:00:02
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 21, 2010, at 19:49:39
Wow, pot turned nasty on me about 20 years ago. I have a panic attack if I even smell the stuff, weird huh! It use to be so relaxing and enjoyable in my late teens.
It began revving me up at first and then I'd start getting paranoid. Slowly over the course of a couple of years it would just send me into chronic panic/anxiety attacks, where I'd literally have to hide under the bed screaming call an ambulance, I'm having a heart attack. For me it's absolutely horribly stuff. I hate it and haven't touched it in 20 years. I shudder just thinking about it.
Posted by chujoe on August 25, 2010, at 19:37:02
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by weatherfreak on August 25, 2010, at 4:00:02
Yeah, I had the same sort of reaction, also about 20 years ago & haven't smoked since, though I'd been a heavy user in my youth. But pot began to make me feel very dissociated, as if I were standing next to myself. then I'd get paranoid, etc. I first noticed this change in effect about the time the new hybrid varieties emerged, which were much more potent that the stuff I grew up smoking.
Posted by weatherfreak on August 25, 2010, at 23:25:48
In reply to Re: Marijuana as a Medication in Depress and Anxiety » weatherfreak, posted by chujoe on August 25, 2010, at 19:37:02
> Yeah, I had the same sort of reaction, also about 20 years ago & haven't smoked since, though I'd been a heavy user in my youth. But pot began to make me feel very dissociated, as if I were standing next to myself. then I'd get paranoid, etc. I first noticed this change in effect about the time the new hybrid varieties emerged, which were much more potent that the stuff I grew up smoking.
DITTO!!!!!!!!!
When I dissociate, even though it's a totally different feeling, it's right up there with a panic attack.
Posted by sigismund on August 26, 2010, at 18:45:34
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by weatherfreak on August 25, 2010, at 4:00:02
>Wow, pot turned nasty on me about 20 years ago.
This is a very common pattern.
Posted by morgan miller on August 26, 2010, at 21:25:40
In reply to Re: Marijuana as a Medication in Depress and Anxiety » weatherfreak, posted by sigismund on August 26, 2010, at 18:45:34
> >Wow, pot turned nasty on me about 20 years ago.
>
> This is a very common pattern.A good reason not to pick ups smoking pot as a habit or treatment.
Posted by weatherfreak on August 26, 2010, at 23:03:28
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by morgan miller on August 26, 2010, at 21:25:40
> > >Wow, pot turned nasty on me about 20 years ago.
> >
> > This is a very common pattern.
>
> A good reason not to pick ups smoking pot as a habit or treatment.
>Not if you have a psychiatric condition, it's usually seriously compounded by it, or if it's under lying it comes out to say, "Hi there."
Posted by islan on August 27, 2010, at 8:09:12
In reply to Re: Marijuana as a Medication in Depress and Anxiety » morgan miller, posted by weatherfreak on August 26, 2010, at 23:03:28
Is the age of the smoker relevant?
Here in Canada, the CBC just played a doc on the Nature of Things about how pot smoking in one's early teens may trigger schizophrenia. But what about adults?
I didn't try smoking until I was 21, and didn't become a habitual user until I was 22. Four years later, I've still never experienced anything I'd describe as nasty or scary like some previous posters, whether using the potent big city stuff or someone's milder homegrown. Like I said before, I've actually found it beneficial for my functionality and mind state when facing symptoms of mental illness (not saying the right med combo wouldn't be better, if I knew what that might be).
Is there a big disaster waiting for me around the corner?
Posted by sigismund on August 27, 2010, at 19:37:42
In reply to Re: Marijuana as a Medication in Depress and Anxiety, posted by islan on August 27, 2010, at 8:09:12
>Is there a big disaster waiting for me around the corner?
Not necessarily at all.
The range of responses to marijuana is quite broad.
The effect of smoking might be the main thing to watch.
This is the end of the thread.
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