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Dr. Bob is Robert Hsiung, MD,
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Posted by lil jimi on August 23, 2010, at 14:28:07
There is an interesting article here:
http://www.physorg.com/news201427487.html#firstCmt
<blockquote>
...
"So Duman, colleague George Aghajanian and the Yale team set out to map the molecular action of the drug in the prefrontal cortex of rats that could lead to potential targets for a safer and more easily used drugs. The team discovered that ketamine acts on a pathway that rapidly forms new synaptic connections between neuronsa process called "synaptogenesis."""The pathway is the story. Understanding the mechanism underlying the antidepressant effect of ketamine will allow us to attack the problem at a variety of possible sites within that pathway," Aghajanian said.
"The team identified a critical point in the pathway, the enzyme mTOR, which controls protein synthesis required for new synaptic connections. There are already promising leads on ways to sustain the initial rapid effect of ketamine by intervening at specific downstream targets."
</blockquote>Obviously, there is more research to be done.
Posted by lil jimi on August 23, 2010, at 15:10:45
In reply to ketamine, posted by lil jimi on August 23, 2010, at 14:28:07
This is the better URL for that article:
"Researchers describe secrets of 'magic' antidepressant"
http://www.physorg.com/news201427487.html"It's like a magic drug -- one dose can work rapidly and last for seven to 10 days," said Ronald Duman, professor of psychiatry and pharmacology at Yale and senior author of the study."
We may have forgive Prof. Duman for his hyperbole.
But that may just be me. I don't like 'magic' and 'drug' used together.
Posted by Phillipa on August 23, 2010, at 16:56:37
In reply to Re: ketamine, posted by lil jimi on August 23, 2010, at 15:10:45
Hi I posted an article on ketamine Iv being used for depression. Haven't opened your link yet. Thanks Phillipa
Posted by linkadge on August 23, 2010, at 20:50:43
In reply to ketamine, posted by lil jimi on August 23, 2010, at 14:28:07
Go to your local health food store. Zinc has rapid AD effects and also activates mTOR in mice.
Linkadge
Posted by Phillipa on August 23, 2010, at 22:07:20
In reply to NMDA antagonist ZINC also activates mTOR, posted by linkadge on August 23, 2010, at 20:50:43
Not to be disrespectful Link does it really? Is there some link other than your name (joke) and what dose. Also is it true might restore lost taste and smell been 7 years now. Phillipa
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