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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 23 of 23. This is the beginning of the thread.
Posted by SLS on February 25, 2010, at 10:09:08
Does anyone know if agomelatine (Valdoxan) can be combined with Nardil or Parnate?
Thanks.
- Scott
Posted by Phillipa on February 25, 2010, at 10:55:58
In reply to Adding agomelatine to MAOI?, posted by SLS on February 25, 2010, at 10:09:08
Scott I sure hope your're doing better. I think a lot on here take or have knowledge of ago. I wish I could answer that question. Love Phillipa
Posted by europerep on February 25, 2010, at 14:06:19
In reply to Re: Adding agomelatine to MAOI? » SLS, posted by Phillipa on February 25, 2010, at 10:55:58
hm, agomelatine is so new, so I'm quite sure there is no sufficient data saying it is possible.. servier did test agomelatine in combination with a handful of drugs, but the only real AD among them was fluoxetine.
so I guess it would be up to the individual doctor, maybe in clinical care it might be possible.. but you're from the US right? I don't know whether US doctors can legally prescribe medication not approved by the FDA.. if not, it would be difficult, I guess..
but don't take this as the answer, this is just what I happen to remember..
Posted by shasling on February 25, 2010, at 19:24:15
In reply to Adding agomelatine to MAOI?, posted by SLS on February 25, 2010, at 10:09:08
Scott,
Sorry you are doing poorly. I looked into Valdoxan for Will, and my memory is MAOIs were okay. Cipro is not, nor are other CYP1A2 inhibitors. I thought if MAOIs were contraindicated, it would have borne mentioning.
Posted by willey on February 25, 2010, at 19:37:29
In reply to Adding agomelatine to MAOI?, posted by SLS on February 25, 2010, at 10:09:08
Scott yess you can,and this is based on suz doing hard constant research before getting it.
To her UTTER dismay i just havent choose to use it yet,no reason why just have other options im tweaking.
So what i would say,is the same as ive said before,if unsure of parnate combo,take additonal med at a seperate time of the parnate dosing,i found taking a drug along the exact time dose of parnate seems to expose more dramactily any interaction.
Simply taking an hour after or so seems to decrease this.I have no scieace or data to show this,just plain ole experaince,but its funny how certain people,including u and myself seem to end up with the same ideas with maoi cocktails.
Also as far as getting,well ill say this,where i live it took 8 docs to get maois,one who took em away,so i no longer dare ask for help in augmenting there,yet i always get what i desire with research a med i find might be useful.This does not inlclude scheldule drugs,which i agree and understand.
But you should have no problems at all obtaining agomoeltine.
Sidenote,my most recent addtions were campral as most have seen me constantly push,i do so because of the safety profile,and the strong pro social anti anxiety benifit it provides.
Others i have include little known overseas meds,adaptol, an gaba nick named non benzo drug,and afobazole.I cant say much here,first little is provided on the net about them,and even less in actualy effect.
Last i wil say with caution,that the additon of an extreme micro dose of addderall also seems to be ok in combo,long as a benzo or gaba med is also invovled.
I know thats a lot of info,but the brain is complex and it makes sense that hitting from various angles would be the best way to quiet it.
Posted by Netch on February 26, 2010, at 6:32:20
In reply to Adding agomelatine to MAOI?, posted by SLS on February 25, 2010, at 10:09:08
> Does anyone know if agomelatine (Valdoxan) can be combined with Nardil or Parnate?
>
> Thanks.
>
>
> - ScottMy guess is it can be done if you make sure to check liver enzymes.
I've tried agomelatine for 20 weeks with no success besides some improved sleep.
Posted by SLS on February 26, 2010, at 7:25:39
In reply to Re: Adding agomelatine to MAOI?, posted by willey on February 25, 2010, at 19:37:29
Posted by Sigismund on February 26, 2010, at 22:34:03
In reply to Re: Adding agomelatine to MAOI? » SLS, posted by Netch on February 26, 2010, at 6:32:20
>I've tried agomelatine for 20 weeks with no success besides some improved sleep.
There have been times when I've felt more upset (more distressed) in the daytime than usual, and I attribute this to agomelatine.
It has been said that it may not be wonderful for melancholia, which I suppose is great sadness.
Certainly it can help with sleep.
I also notice a mild euphoria (I suppose you could call it), not like Parnate, but in the same ballpark.
IMO, lower doses may be as effective as higher ones with ago.
Posted by desolationrower on March 2, 2010, at 1:43:47
In reply to Re: Adding agomelatine to MAOI? » SLS, posted by Phillipa on February 25, 2010, at 10:55:58
aren't you already on one of the 5ht2 antagonizing tcas? i don't think the m agonist properties would be helpful with maoi
-d/r
Posted by West on March 13, 2010, at 4:22:14
In reply to Re: Adding agomelatine to MAOI?, posted by desolationrower on March 2, 2010, at 1:43:47
Hi Scott. Good news, It can be done. Someone close to me is taking 25mg with Nardil 90mg - (also lamotrigine) all are being prescribed by a psychiatrist
Posted by SLS on March 13, 2010, at 5:39:27
In reply to Re: Adding agomelatine to MAOI?, posted by West on March 13, 2010, at 4:22:14
> Hi Scott. Good news, It can be done. Someone close to me is taking 25mg with Nardil 90mg - (also lamotrigine) all are being prescribed by a psychiatrist
Thanks, West.
Does this doctor actually write scripts for agomelatine? I don't know if my doctor would be amenable to doing this.
- Scott
Posted by West on March 13, 2010, at 10:50:05
In reply to Re: Adding agomelatine to MAOI? » West, posted by SLS on March 13, 2010, at 5:39:27
Yes. It is available on prescription where I live though. Could your psychiatrist be persuaded ti import it for you? It does seem to be helping.
Posted by Ron Hill on July 2, 2010, at 4:11:58
In reply to Re: Adding agomelatine to MAOI?, posted by West on March 13, 2010, at 4:22:14
> Hi Scott. Good news, It can be done. Someone close to me is taking 25mg with Nardil 90mg - (also lamotrigine) all are being prescribed by a psychiatrist
West,
I am trying my best to convince my p-doc to add 25 mg/night of Valdoxan (agomelatine) to my current 90 mg/day of Nardil. Please read my post and the associated thread via the link below so as to familiarize yourself with my situation:
http://www.dr-bob.org/babble/20100628/msgs/952901.html
This e-mail to you is in regard to the person close to you that is taking agomelatine and Nardil concurrently.
If I give you my p-doc's phone number and e-mail address, would your friend ask his/her p-doc to e-mail or call my p-doc?
My p-doc needs to hear that the patient (your close friend) is doing very well on 25 mg/day of agomelatine and 90 mg/day of Nardil.
I cannot begin to tell you how much this would help me.
You and I can communicate semi-privately via Babble Mail, if you turn on your Babble Mail option. Mine is on. Or, I can post my e-mail address to you (in code) on Babble Mail and we can communicate via e-mail.
Thank you, West!
-- Ron
dx: Bipolar II with ultra rapid cycling, and mild OCPD
600 mg/day Trileptal
200 mg/day Lamictal
500 mg/day Keppra
90 mg/day Nardil3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
35 ml of Calsons Bottled Fish Oil
100 mg/day phosphatidylserene
Centrum Chewable Multi-vitamins; Only 100% of all the usual vitamins
2000 IU Vitamin E
850 mg/day of Mg 212% of RDA (as 5 grams of MgMalate).
Dark therapy via LowBlueLight glasses (When I remember)
Whats next to add:25 mg/day agomelatine (if my p-doc wakes up and smells the roses due to my submitted research) {Valdoxan}
300 mg/day of lithum carbonate
CoQ10
NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid, + Vitamin C
GTF Chromium
Cromium Picolinate
Cinnamon
Posted by Ron Hill on July 2, 2010, at 4:27:19
In reply to Re: Adding agomelatine to MAOI? » West, posted by Ron Hill on July 2, 2010, at 4:11:58
Posted by West on July 6, 2010, at 18:30:00
In reply to Re: Adding agomelatine to MAOI? » West, posted by Ron Hill on July 2, 2010, at 4:11:58
Ron,
I read your message with interest; you seem to have all the facts at your fingertips. In my opinion the addition of ago would be less likely than stimulants to provoke a hypertensive crisis.
The person I mentioned started on 25mg without issue. They are now taking 50mg.
I will try and turn on my babble-mail mail now. I would be pleased to help you, SLS, and any others as best I can.
Posted by Ron Hill on July 16, 2010, at 3:57:25
In reply to Ron, posted by West on July 6, 2010, at 18:30:00
> Ron,
> I read your message with interest; you seem to have all the facts at your fingertips. In my opinion the addition of ago would be less likely than stimulants to provoke a hypertensive crisis.
> The person I mentioned started on 25mg without issue. They are now taking 50mg.> I will try and turn on my babble-mail mail now. I would be pleased to help you, SLS, and any others as best I can.
------------------------------West,
Thank you VERY much for your willingness to help. As it turns out, I am able to obtain Valdoxan (agomelatine) and my p-doc is on-board. So the bottom line is that I do not need to bother you after all.
Your reply to me is an example of good people willing to help others. This is when PB is at its best! Thank you again, West.
-- Ron
Posted by West on July 16, 2010, at 11:48:49
In reply to Re: Valdoxan (agomelatine) » West, posted by Ron Hill on July 16, 2010, at 3:57:25
Great news Ron! Please keep us updated, I'd be interested to know how you get on - and whether the ago complements the Nardil.
You may find sleep worsening or daytime sleepiness a little problematic initially. This usually passes in 2-3 weeks. While it seems not to improve sleep for some (read: me), for others it works wonders.
It's a very mild mannered medicine, I shouldn't think you'll have any problems.
West
Posted by Ron Hill on July 16, 2010, at 12:02:28
In reply to Re: Valdoxan (agomelatine), posted by West on July 16, 2010, at 11:48:49
> Great news Ron! Please keep us updated, I'd be interested to know how you get on - and whether the ago complements the Nardil.
> You may find sleep worsening or daytime sleepiness a little problematic initially. This usually passes in 2-3 weeks. While it seems not to improve sleep for some (read: me), for others it works wonders.
> It's a very mild mannered medicine, I shouldn't think you'll have any problems.
------------------------Thank you, West.
I will try to start a thread providing a daily report.
Thanks for the heads-up on the early sleeping side effect. Most of what I've read says that agomelatine starts working in the first day or two and that the sleep is great from the get-go.
-- Ron
Posted by inanimate peanut on July 16, 2010, at 17:57:11
In reply to Re: Valdoxan (agomelatine) » West, posted by Ron Hill on July 16, 2010, at 12:02:28
A daily-ish thread would be great. I'm so glad you got your p-doc on board and all is go. Congrats!
Posted by Ron Hill on July 16, 2010, at 18:57:05
In reply to Re: Valdoxan (agomelatine), posted by inanimate peanut on July 16, 2010, at 17:57:11
> A daily-ish thread would be great. I'm so glad you got your p-doc on board and all is go. Congrats!
----------------------Thanks. Let's see if it works. If it doesn't work, after all of my begging, pleading, crying, and more pleading, my p-doc might snicker under his breath.
But hey, we never know until we try the p-med. It is unfortunate, but the state of the art in selecting p-meds is still in the elementary stage of trial-and-error; albeit educationally guided trial-and-error.
-- Ron
Posted by Phillipa on July 16, 2010, at 20:39:38
In reply to Re: Valdoxan (agomelatine) » inanimate peanut, posted by Ron Hill on July 16, 2010, at 18:57:05
Ron sure hope it works for you. Phillipa
Posted by Dr. Fischer-Terworth on March 13, 2011, at 6:19:10
In reply to Adding agomelatine to MAOI?, posted by SLS on February 25, 2010, at 10:09:08
Hi,I think it's possible. I am on tranylcypromine
40 mg for OCD and anxiety, very effective and
tolerable without diet, despite of insomnia.
As I developed Zolpidem tolerance after 6
years my psychiatrist suggested agomelatine
25 mg. It has good effects, I think kind of
mood stabilizing effects, and sleep has improved
at least moderately.
I tolerate the combination without andy side
effects. Maybe it's the same with the Phenelzine
also being an irreversible MAOI. Maybe it
reduces the Tranylcypromine's stimulating effect
a bit.
Serotonergic risks can be excluded because
agomelatine does not raise serotonin levels,
it justs blocks 5HT2c-receptors.Hope this can be helpful.
Best wishes, Christian FT
Posted by SLS on March 13, 2011, at 14:13:34
In reply to Re: Adding agomelatine to MAOI? » SLS, posted by Dr. Fischer-Terworth on March 13, 2011, at 6:19:10
This is the end of the thread.
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