![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by George Romero on March 31, 2010, at 15:56:05
Can anyone explain why my morning parnate dose makes me super-sleepy and my evening dose makes me wired? Does anyone have any experience moving doses around? i'm wondering if weighting the doses differently would help--like maybe taking more in the morning/less at night or vice versa would help. seems like taking more of either dose just makes the effect worse.
Posted by linkadge on March 31, 2010, at 17:24:52
In reply to Parnate: drowsy in morning, insomina at night?, posted by George Romero on March 31, 2010, at 15:56:05
MAO inhibitors are notorious for disrupting the circadian ryhthm. MAO metabolizes melatonin.
Linkadg
Posted by shalhevet on April 2, 2010, at 18:51:01
In reply to Parnate: drowsy in morning, insomina at night?, posted by George Romero on March 31, 2010, at 15:56:05
The only thing I know is that I can't take my last dose of Parnate later than around 2:00pm or I'm guaranteed not to sleep. The afternoon fatigue is so intense, but I haven't figured it out yet, either.
I've tried taking my largest dose just before bed so that my blood pressure drops while I'm (hopefully) asleep, but then waking up becomes a struggle, too.
Posted by George Romero on April 4, 2010, at 17:32:27
In reply to Re: Parnate: drowsy in morning, insomina at night?, posted by shalhevet on April 2, 2010, at 18:51:01
> The only thing I know is that I can't take my last dose of Parnate later than around 2:00pm or I'm guaranteed not to sleep. The afternoon fatigue is so intense, but I haven't figured it out yet, either.
>
> I've tried taking my largest dose just before bed so that my blood pressure drops while I'm (hopefully) asleep, but then waking up becomes a struggle, too.Do you mind if I ask what dose you are on, and how long? I'm only on 20mg. Was taking 10mg/5mg/5mg. Am going to try 15mg/5mg. My doc thinks it's possible that i'll get more dopamine action in the a.m. if i take more of my dose in the a.m.--although to tell you the truth, it sounded more like a wild guess than a suggestion based on acutal science. i guess it's worth a shot.
Posted by shalhevet on April 4, 2010, at 21:34:12
In reply to Re: Parnate: drowsy in morning, insomina at night? » shalhevet, posted by George Romero on April 4, 2010, at 17:32:27
I've been taking 80mg pretty consistently for awhile now (a few months at this dose), playing with 100mg sometimes. The insomnia/fatigue thing has been a constant from day 1, though. I recently mentioned it here:
http://www.dr-bob.org/babble/20100318/msgs/940842.html(And I made a mistake in my post: I responded at 70mg and 90mg; 50mg and 80mg were what I backed off to when it pooped out. Not that it's super relevant, just mentioning it).
Right now I do 20-40-20, at 7:00, 10:00, and noon. The doses are split up mainly because of the hypotension issue. I don't find Parnate stimulating (plenty of sympathomimetic side-effects, though...), so the timing isn't huge as long as I get it all before 2:00ish. I also take Dexedrine and try to not take them too closely together, or I sometimes end up with urinary hesitancy.
I've been wondering if the intense fatigue I experience may be a REM rebound. I can't sleep at all at night without a sedative (and I wake up tired), and I'll sometimes have very deep 2-3 hour naps during the day and I'll be totally helpless to it, but it'll be my most resorative sleep. I've had 12+ hour crashes like that, too, no sleep aid or anything. I'd find it hard to believe that I have narcolepsy, so I'm thinking that perhaps a reason for the weird insomnia+fatigue combo is that Parnate wrecks sleep architecture somehow beyond simply making it difficult to fall asleep.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
[email protected]
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.