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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
Hi Everybody:
The Parnate withdrawal symptoms I was having (dizzy, chills, terrible itching, nausea, brain fog, achy joints) have never gone away! And now full blown Rheumatoid Arthritis has laid me low. I get these exacerbations on occasion, but not this bad.I think I'm allergic to Parnate. Damn.
Parnate is the only AD in 15 years that has really helped me. It gets down to a very deep place where my obsession with suicide lies. No other AD has come close. But I'm a mess and getting worse.I finally wrote an email to my pdoc tonight to tell him what's going on and see what he thinks.
I've probably been allergic to Parnate since the git-go and that's why it took me 5 miserable months to get on it. Then it was good!
It was going from 80mg down to 60mg that stirred everything up. I can't believe I'm still having such bad withdrawal symptoms after a month!There is not another AD out there that I can take, except Wellbutrin, which only helps about 60%. I wish I could take a little bit of Parnate and add Wellbutrin, but aren't those two that do not go together?
Boy am I ever bummed.
Sorry to be such a downer.
Gayle
Posted by Phillipa on December 31, 2009, at 0:23:30
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
Gayle I wondered how you were doing knew you had company. I'm so very sorry the parnate is doing this to you. Do you feel an autoimmune response is causing it? Seriously. What med do you take for the arthritis? I sure hope your doc gets back to you . Love Phillipa
Posted by willey on December 31, 2009, at 2:14:23
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
Very sorry u feel so bad,but yess parnate w/d is absolutly horrid.
First im curious why ur getting off it u said it works?
Second id ask are u postive ur allergic,or is this a theory,id recomend finding out for sure.
Ans yess,you can add wellbutrin to parnate,among other things such as mirapex another dopamine drug,u have options,i hate to see u suffer.
p.s thank you for the below posted compliment,i appreciate it.
Posted by SLS on December 31, 2009, at 2:36:41
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
> Hi Everybody:
>
> The Parnate withdrawal symptoms I was having (dizzy, chills, terrible itching, nausea, brain fog, achy joints) have never gone away! And now full blown Rheumatoid Arthritis has laid me low. I get these exacerbations on occasion, but not this bad.
>
> I think I'm allergic to Parnate. Damn.
> Parnate is the only AD in 15 years that has really helped me. It gets down to a very deep place where my obsession with suicide lies. No other AD has come close. But I'm a mess and getting worse.
>
> I finally wrote an email to my pdoc tonight to tell him what's going on and see what he thinks.
> I've probably been allergic to Parnate since the git-go and that's why it took me 5 miserable months to get on it. Then it was good!
> It was going from 80mg down to 60mg that stirred everything up. I can't believe I'm still having such bad withdrawal symptoms after a month!I don't think you are experiencing withdrawal per se.
As weird as it sounds, you might be experiencing dysautonomia caused by being in an "in-between" state. This is just a pet theory of mine. If this is true, most of these things should disappear when you increase the dosage. In other words, you are caught in the middle between response and non-response, and it is driving your body crazy. That kind of physiological stress will set off a RA episode.
Any heart palpitations, sweating, or dry mouth.?
- Scott
Posted by janejane on December 31, 2009, at 9:30:07
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
Sorry to hear you're feeling bad. Don't really have any advice, but just wanted to give support. I think Scott has a really interesting theory. Could you dose back up? It's not clear why you were reducing.
Posted by bleauberry on December 31, 2009, at 10:44:58
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
I forgot, why did you have to go down from 80mg? Could you not stay at 80mg? I don't know enough about your situation, but it just seems logical to go back to 80mg and deal with whatever it was that made the decision to go down in dose. If it was a doc, get another doc. If it was a side effect, keep exploring ways to counter it.
I've tried parnate 3 times at miniscule doses...2.5mg once every other day. I could already feel it working by the end of day 2, day 3 for sure. I am sensitive. Anyway, these were not bonafide efforts to get on the drug, merely tests to see if I could even consider it. So many meds I just cannot take due to bizarre complications, usually a deep worsening of depression. Parnate didn't do that except for the first 4 hours after dosing.
What I'm getting at is this. Even in such a tiny dose and for such a short time (never on it more than 5 days), I got pretty much the same withdrawal bizarreness you are experiencing. The itching was insane. I couldn't figure that out. I could tell when the MAO enzymes were making a comeback as the previous dose from a few days wore off, because the itching, intense anxiety, sinking darkness, pains, all the stuff you mentioned, came on fairly strong.
So I can only imagine how intense your reactions are, with a 20mg difference and being on it longer.
I can't help but wonder when I see such bizarre stuff going on...especially the arthritis stuff...if there isn't something else going on that you are not aware of. I won't go into anything specifically because people here get sick of me talking about it, but it deserves mention that when bizarre things happen on meds (above and beyond normal expected side effects or withdrawals) and when arthritis flare ups exist, that is a fairly loud horn announcing there is more to the story than you know. With respect to the phrase mileage varies, sometimes things stand out as being a bit more profound than simply that.
I'm sure SLS thoughts on being stuck in the middle, added to withdrawal, make a ton of sense too. I just can't help wondering if it isn't one of the above, but rather all of the above.
I sure wish you could get away from the 60mg dose. Doesn't sound like a safe place to be.
Posted by bulldog2 on December 31, 2009, at 14:37:02
In reply to Re: Parnate Update - I feel awful!!, posted by bleauberry on December 31, 2009, at 10:44:58
> I forgot, why did you have to go down from 80mg? Could you not stay at 80mg? I don't know enough about your situation, but it just seems logical to go back to 80mg and deal with whatever it was that made the decision to go down in dose. If it was a doc, get another doc. If it was a side effect, keep exploring ways to counter it.
>
> I've tried parnate 3 times at miniscule doses...2.5mg once every other day. I could already feel it working by the end of day 2, day 3 for sure. I am sensitive. Anyway, these were not bonafide efforts to get on the drug, merely tests to see if I could even consider it. So many meds I just cannot take due to bizarre complications, usually a deep worsening of depression. Parnate didn't do that except for the first 4 hours after dosing.
>
> What I'm getting at is this. Even in such a tiny dose and for such a short time (never on it more than 5 days), I got pretty much the same withdrawal bizarreness you are experiencing. The itching was insane. I couldn't figure that out. I could tell when the MAO enzymes were making a comeback as the previous dose from a few days wore off, because the itching, intense anxiety, sinking darkness, pains, all the stuff you mentioned, came on fairly strong.
>
> So I can only imagine how intense your reactions are, with a 20mg difference and being on it longer.
>
> I can't help but wonder when I see such bizarre stuff going on...especially the arthritis stuff...if there isn't something else going on that you are not aware of. I won't go into anything specifically because people here get sick of me talking about it, but it deserves mention that when bizarre things happen on meds (above and beyond normal expected side effects or withdrawals) and when arthritis flare ups exist, that is a fairly loud horn announcing there is more to the story than you know. With respect to the phrase mileage varies, sometimes things stand out as being a bit more profound than simply that.
>
> I'm sure SLS thoughts on being stuck in the middle, added to withdrawal, make a ton of sense too. I just can't help wondering if it isn't one of the above, but rather all of the above.
>
> I sure wish you could get away from the 60mg dose. Doesn't sound like a safe place to be.When I took parnate back in March 2009 my sciatica in my back legs disappeared after about a week on the drug. I've been off parnate for awhile and this December the winter cold has triggered a reoccurrence.
Posted by bulldog2 on December 31, 2009, at 14:39:26
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
> Hi Everybody:
>
> The Parnate withdrawal symptoms I was having (dizzy, chills, terrible itching, nausea, brain fog, achy joints) have never gone away! And now full blown Rheumatoid Arthritis has laid me low. I get these exacerbations on occasion, but not this bad.
>
> I think I'm allergic to Parnate. Damn.
> Parnate is the only AD in 15 years that has really helped me. It gets down to a very deep place where my obsession with suicide lies. No other AD has come close. But I'm a mess and getting worse.
>
> I finally wrote an email to my pdoc tonight to tell him what's going on and see what he thinks.
> I've probably been allergic to Parnate since the git-go and that's why it took me 5 miserable months to get on it. Then it was good!
> It was going from 80mg down to 60mg that stirred everything up. I can't believe I'm still having such bad withdrawal symptoms after a month!
>
> There is not another AD out there that I can take, except Wellbutrin, which only helps about 60%. I wish I could take a little bit of Parnate and add Wellbutrin, but aren't those two that do not go together?
>
> Boy am I ever bummed.
>
> Sorry to be such a downer.
>
> GayleDid you have ra when you started parnate and were ramping the dose up?
Posted by ColoradoSnowflake on December 31, 2009, at 15:06:49
In reply to Re: Parnate Update - I feel awful!! » ColoradoSnowflake, posted by SLS on December 31, 2009, at 2:36:41
Scott:
No, I don't have sweating or rapid heartrate. I do have awful dry mouth...have since starting Parnate.
I want to come down on it some. I feel totally toxic.
How can I do that?
Do I need some kind of meds to help me with all these symptoms? I could probably get some scripts from my doc.
Thanks,
Gayle
Posted by SLS on December 31, 2009, at 15:31:29
In reply to SLS Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 15:06:49
> Scott:
> No, I don't have sweating or rapid heartrate. I do have awful dry mouth...have since starting Parnate.Ok. I really don't know how to account for your experiences. I wouldn't want to encourage you to do something that will make the situation worse.
- Scott
Posted by Justherself54 on December 31, 2009, at 17:47:23
In reply to SLS Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 15:06:49
The only thing that seems to help me when I am withdrawing from a med is a benzo. It doesn't make it all go away, just makes it a little more tolerable. I hope you feel better. I know what you mean when you say you feel toxic. I experience that with SNRI's for some reason. Take care.
Posted by Phillipa on December 31, 2009, at 19:50:16
In reply to Re: SLS Parnate Update - I feel awful!! » ColoradoSnowflake, posted by Justherself54 on December 31, 2009, at 17:47:23
I hate to answer for another if my memory is correct she was experiencing some falling or about to fall. I'm wondering if since RA is autoimmune and now dry mouth if could be Sjournes Syndrome another autoimmune disorder as one often has more than one and something can trigger the other? Phillipa
Posted by Maxime on January 1, 2010, at 13:44:28
In reply to Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 0:12:42
Gayle, I don't have any advice for you. I just wanted to say that I am sorry you are feeling so unwell. Have you discussed going back up to 80 mg of Parnate with your doctor? I really hope you aren't allergic to the medication because it has done so much for you. Have you ever tried Nardil? Do you think that might be one option?
Hang in there. I hope you and your doctor come up with some ideas of how you can stay on the Parnate or try Nardil without feeling worse.
Hugs for you.
Posted by Maxime on January 1, 2010, at 13:48:34
In reply to SLS Parnate Update - I feel awful!!, posted by ColoradoSnowflake on December 31, 2009, at 15:06:49
Hi again
Gayle there are products for dry mouth. I think the name is Biotin. There is a toothpaste and there is fake saliva that you can buy. Your dentist would know what's out there because dry mouth is bad for your teeth. I find the nortriptyline gives me dry mouth more than the Parnate and it's not pleasant. So ask your dentist or speak to the pharmacist about these products because they are available over the counter. I think I am going to do the same.
Posted by ColoradoSnowflake on January 5, 2010, at 11:57:59
In reply to Re: SLS Parnate Update - I feel awful!! » ColoradoSnowflake, posted by Maxime on January 1, 2010, at 13:48:34
Hi Maxie:
When I went to the dentist end of December he gave me a bag with dry mouth stuff in it. I felt too bad to even look in the bag until a few days ago and it was samples of the Biotene products you mentioned. I tried the toothpaste and the mouthwash and it didn't help me anymore than regular products do! I'll keep using it until its gone, but so far I'm not impressed!
Now that I'm down to 50mg Parnate I still have dry-mouth, but not nearly so bad.
It's still the itching that's bothering me, and now my ears itch and ring. Weird.
Thanks for your support!
Hugs,
g
Posted by Phillipa on January 5, 2010, at 19:40:52
In reply to Parnate Update - I feel awful!!-Maxime, posted by ColoradoSnowflake on January 5, 2010, at 11:57:59
It must be autoimmune or severe allergic reaction. Just my unofficial thoughts. Phillipa
This is the end of the thread.
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