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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by bleauberry on December 28, 2009, at 19:10:36
Hi Scott,
Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
The urinary constriction of Savella, I am not sure if that is a bladder thing, a urinary canal thing, or a prostate thing, or all of the above at the same time. Probably all of the above is my guess. But maybe not. It might be just prostate or just canal or just bladder.
I was looking on the web for info and all I could find was that it is for strengthening weak bladder muscles. I could not find any information on whether it helps open up a prostate gland that is artificially constricted by a drug such as Savella (probably cause is noradrenaline, but could be similar to tricyclics....it can have some dry mouth and constipation similar to tricyclics).
Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.
Posted by SLS on December 29, 2009, at 6:24:25
In reply to SLS Bethanecol Question, posted by bleauberry on December 28, 2009, at 19:10:36
Hi BB.
> Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
I don't think bethanechol works locally, but, rather, as a modulator of autonomic activity via the stimulation of muscarinic ACh receptors. It increases parasympathetic tone. Apparantly, it increases the tone (state of contracture) of the walls of the bladder. The bladder can "squeeze" more forcefully.
> The urinary constriction of Savella, I am not sure if that is a bladder thing
I think anything that increases the tone of the sympathetic nervous system will produce urinary retention. NE reuptake inhibition is one mechanism by which this occurs.
> Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.
It is important to resolve any obstruction before using bethanechol. I don't know if this is simply because the bethanechol would have no therapeutic effect or if there might be untoward sequalae as a result of using it in such a situation.
Please let me know what you find.
- Scott
Posted by bulldog2 on December 29, 2009, at 12:40:44
In reply to SLS Bethanecol Question, posted by bleauberry on December 28, 2009, at 19:10:36
> Hi Scott,
>
> Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
>
> The urinary constriction of Savella, I am not sure if that is a bladder thing, a urinary canal thing, or a prostate thing, or all of the above at the same time. Probably all of the above is my guess. But maybe not. It might be just prostate or just canal or just bladder.
>
> I was looking on the web for info and all I could find was that it is for strengthening weak bladder muscles. I could not find any information on whether it helps open up a prostate gland that is artificially constricted by a drug such as Savella (probably cause is noradrenaline, but could be similar to tricyclics....it can have some dry mouth and constipation similar to tricyclics).
>
> Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.hytrin will reverse the bladder constriction.
Posted by bleauberry on December 29, 2009, at 16:27:44
In reply to Re: SLS Bethanecol Question » bleauberry, posted by SLS on December 29, 2009, at 6:24:25
Thanks for trying to help, SLS. Some of the terminology is over my head. Parasympathetic, I don't know what that is.
There is no obstruction at baseline. But when the NE of Savella kicks in or maybe it is some muscarinic effect (though Savella has supposedly little effect on this, maybe I am super sensitive to it), when those things kick in, boy does the whole system tighten up. Even a previously healed wrist tendonitis can feel aggravated...not pain, but a definite tightening of the fingers and wrist.
I understand how Bethanecol affects the bladder, but I wonder if it does similar action throughout the body on other muscles or tissues?
> Hi BB.
>
> > Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
>
> I don't think bethanechol works locally, but, rather, as a modulator of autonomic activity via the stimulation of muscarinic ACh receptors. It increases parasympathetic tone. Apparantly, it increases the tone (state of contracture) of the walls of the bladder. The bladder can "squeeze" more forcefully.
>
> > The urinary constriction of Savella, I am not sure if that is a bladder thing
>
> I think anything that increases the tone of the sympathetic nervous system will produce urinary retention. NE reuptake inhibition is one mechanism by which this occurs.
>
> > Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.
>
> It is important to resolve any obstruction before using bethanechol. I don't know if this is simply because the bethanechol would have no therapeutic effect or if there might be untoward sequalae as a result of using it in such a situation.
>
> Please let me know what you find.
>
>
> - Scott
Posted by bleauberry on December 29, 2009, at 16:29:30
In reply to Re: SLS Bethanecol Question, posted by bulldog2 on December 29, 2009, at 12:40:44
Hytrin? Never heard of it.
Have you ever used it?
Can you tell me more about it? How it works? What it is usually prescribed for? Mechanism? Anything you know would be helpful.
> > Hi Scott,
> >
> > Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
> >
> > The urinary constriction of Savella, I am not sure if that is a bladder thing, a urinary canal thing, or a prostate thing, or all of the above at the same time. Probably all of the above is my guess. But maybe not. It might be just prostate or just canal or just bladder.
> >
> > I was looking on the web for info and all I could find was that it is for strengthening weak bladder muscles. I could not find any information on whether it helps open up a prostate gland that is artificially constricted by a drug such as Savella (probably cause is noradrenaline, but could be similar to tricyclics....it can have some dry mouth and constipation similar to tricyclics).
> >
> > Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.
>
> hytrin will reverse the bladder constriction.
Posted by bulldog2 on December 31, 2009, at 16:53:03
In reply to Re: SLS Bethanecol Question » bulldog2, posted by bleauberry on December 29, 2009, at 16:29:30
> Hytrin? Never heard of it.
>
> Have you ever used it?
>
> Can you tell me more about it? How it works? What it is usually prescribed for? Mechanism? Anything you know would be helpful.
>
> > > Hi Scott,
> > >
> > > Do you know, is Bethanecol specific for just the bladder or does it also involve the prostate?
> > >
> > > The urinary constriction of Savella, I am not sure if that is a bladder thing, a urinary canal thing, or a prostate thing, or all of the above at the same time. Probably all of the above is my guess. But maybe not. It might be just prostate or just canal or just bladder.
> > >
> > > I was looking on the web for info and all I could find was that it is for strengthening weak bladder muscles. I could not find any information on whether it helps open up a prostate gland that is artificially constricted by a drug such as Savella (probably cause is noradrenaline, but could be similar to tricyclics....it can have some dry mouth and constipation similar to tricyclics).
> > >
> > > Can you help me out with this? It could actually be a dangerous scenario to have a powerful drug-induced bladder but a constricted prostate. I would need some kind of hope that the drug will help both simultaneously, not knowing for sure which is at fault.
> >
> > hytrin will reverse the bladder constriction.
>
>Here's a good one that I use. It counteracts the actions of drugs that affect norepinephrine. It relaxes the prostate. I believe it works similar to hytrin.
http://www.doxazosin.com/index.html?gclid=CNe_t5jhgZ8CFYdd5QodtVZAhQ
This is the end of the thread.
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