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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by linkadge on July 1, 2009, at 16:40:10
I was doing a little reading.
Mice that lack the TREK-1 potasium channel exhibit a depression resistant phenotype.
SSRI antidepressants (and caffiene!) inhibit TREK-1 activities.
http://eprints.iisc.ernet.in/3579/1/A141.pdf
Linkadge
Posted by linkadge on July 1, 2009, at 16:43:13
In reply to New mechanism for the AD effect of CAFFIENE, posted by linkadge on July 1, 2009, at 16:40:10
Turmeric also inhibits TREK-1
Linkadge
Posted by linkadge on July 1, 2009, at 16:46:09
In reply to Re: and turmeric, posted by linkadge on July 1, 2009, at 16:43:13
Arachidonic acid (which is a metabolite of an omega-6 fatty acid) is elevated in the flinders sensitive depressive rat breed. It apparently activates TREK-1 currents.
http://www.sciencemag.org/cgi/content/abstract/244/4909/1174
Linkadge
Posted by linkadge on July 1, 2009, at 16:47:10
In reply to Re: arachidonic acid, posted by linkadge on July 1, 2009, at 16:46:09
http://oss.mcgill.ca/everyday/week15.pdf
Linakdge
Posted by linkadge on July 1, 2009, at 16:51:15
In reply to Re: more readings, posted by linkadge on July 1, 2009, at 16:47:10
Zinc also has antidepressant properties.
Linkadge
Posted by mogger on July 1, 2009, at 18:29:20
In reply to Re: zinc inhibits TREK-1, posted by linkadge on July 1, 2009, at 16:51:15
very interesting study however it doesn't list the doses used dose it? Or am I not seeing it correctly. I would be interested to know the dose so I could use it.
mogger
Posted by Phillipa on July 1, 2009, at 18:49:48
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 18:29:20
Where's the caffeine can't find it? Phillipa on bioidentical hormones micronized. Estrogen and Testosterone have risen. And FSH is down.
Posted by linkadge on July 1, 2009, at 20:19:35
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 18:29:20
No it doesn't list the dose. Compared to other agents zinc is less potent. The SSRI antidepressants fluoxetine, paroxetine and sertraline also inhibit TREK-1 channels in the order of potence sertraline > paroxetine > fluoxetine.
Lamotrigine is a TREK-1 channel inhibtor which may account for its antidepressant like effect.
Perhaps newer agents with high selectivity and potency for this target will prove to be effective antdepressant agents.
Linkadge
Posted by mogger on July 1, 2009, at 20:38:23
In reply to Re: zinc inhibits TREK-1, posted by linkadge on July 1, 2009, at 20:19:35
I am trying rilutek and as I am sure you know it is a glutamate modulator like lamotrigine. Do you think rilutek could also be a TREK-1 channel inhibitor?
Posted by linkadge on July 1, 2009, at 21:30:11
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 20:38:23
I am not sure, there is some interaction between glutamate receptors and potasium chanels.
This study suggests that riluzole initially activates trek-1 followed by an inhibition.
http://molpharm.aspetjournals.org/cgi/content/abstract/57/5/906
Linkadge
Posted by mogger on July 1, 2009, at 22:01:07
In reply to Re: zinc inhibits TREK-1, posted by linkadge on July 1, 2009, at 21:30:11
Very interesting however it seems odd that it stops what it just starts. Why would it activate in the first place if then it was going to next inhibit it?
Posted by linkadge on July 2, 2009, at 7:58:50
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 22:01:07
Who knows, the interaction of transmitter systems is way too completx. Like how alcohol can be stimulating depending on timing and dose etc.
Linkadge
Posted by Lou Pilder on July 3, 2009, at 6:52:00
In reply to Re: zinc inhibits TREK-1, posted by linkadge on July 2, 2009, at 7:58:50
Posted by Larry Hoover on July 3, 2009, at 19:58:54
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 18:29:20
> very interesting study however it doesn't list the doses used dose it? Or am I not seeing it correctly. I would be interested to know the dose so I could use it.
> moggerI can tell you the safe range of zinc intake. Don't take more than 45 mg/day on a chronic basis.
Lar
Posted by Larry Hoover on July 3, 2009, at 20:00:45
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 22:01:07
> Very interesting however it seems odd that it stops what it just starts. Why would it activate in the first place if then it was going to next inhibit it?
There are many signalling systems that have dose-dependent response type, on top of dose-dependent response magnitude. You simply can't assume a linear dose-response curve across all concentrations of exposure.
Lar
Posted by Dr. Bob on July 5, 2009, at 17:13:54
In reply to Re: zinc inhibits TREK-1, posted by linkadge on July 1, 2009, at 16:51:15
> http://kar.kent.ac.uk/5641/
>
> Zinc also has antidepressant properties.Please share this site with others by not posting more than 3 consecutive follow-ups in the same thread.
But please don't take this personally, this doesn't mean I don't like you or think you're a bad person, and I'm sorry if this hurts you.
More information about posting policies is in the FAQ:
http://www.dr-bob.org/babble/faq.html#three
http://www.dr-bob.org/babble/faq.html#enforceFollow-ups regarding these issues should be redirected to Psycho-Babble Administration.
Thanks,
Bob
Posted by linkadge on July 5, 2009, at 18:59:25
In reply to Re: consecutive follow-ups » linkadge, posted by Dr. Bob on July 5, 2009, at 17:13:54
Sure. OK.
I didn't think it was an issue since they were essentially all small additions to the original idea.
I suppose I should gather my ideas a little better before posting.
Linkadge
Posted by Dr. Bob on July 6, 2009, at 0:51:11
In reply to Re: consecutive follow-ups, posted by linkadge on July 5, 2009, at 18:59:25
This is the end of the thread.
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