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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by sowhysosad on April 24, 2009, at 15:25:18
Anyone have any experiences, or would you like to make an intelligent guess?
I've taken codeine a few times this week, and the resultant dopamine boost has had a remarkable effect on my depression and anxiety. I'm hoping NADH will have a longer-term effect taken once or twice daily.
I'm antidepressant-free at the moment.
Posted by Alexanderfromdenmark on April 26, 2009, at 17:53:13
In reply to How long 'til NADH boosts dopamine?, posted by sowhysosad on April 24, 2009, at 15:25:18
> Anyone have any experiences, or would you like to make an intelligent guess?
>
> I've taken codeine a few times this week, and the resultant dopamine boost has had a remarkable effect on my depression and anxiety. I'm hoping NADH will have a longer-term effect taken once or twice daily.
>
> I'm antidepressant-free at the moment.How did you get codeine? How long time you taken NADH? I've ordered some and quite interested to hear whether it works or whether its another one of those overhyped supplements that dosn't deliver.
Posted by sowhysosad on April 26, 2009, at 19:07:36
In reply to Re: How long 'til NADH boosts dopamine?, posted by Alexanderfromdenmark on April 26, 2009, at 17:53:13
> How did you get codeine?
I just combined 2 over-the-counter meds: 2x ibuprofen/codeine (12.8mg of codeine per tablet), plus 2x paracetamol/codeine (8mg per tablet). That way I didn't exceed the recommended dose for ibuprofen or paracetamol/
> How long time you taken NADH? I've ordered some and quite interested to hear whether it works or whether its another one of those overhyped supplements that dosn't deliver.
This is only my third day and I wasn't expecting it to work so soon but I'm definitely feeling a dopaminergic effect. I've had a tiny bit of caffeine and some nicotine which will boost it, but no more than usual.
The only other factor coming into play is that I quit imipramine only a week ago, so my D2 receptors will still be supersensitive.
It also feels like my dopamine system is "bouncing back" after somehow being suppressed by the imipramine, although the only relevant research I could find claimed tricyclics boost dopamine in some parts of the brain. That's why I originally decided to try one!
However, the atypical features of my depression (oversleeping and binge eating) got progressively worse on imipramine, which woud imply a problem with dopamine.
I'm tempted to drop the NADH dose a little and add a bit of 5HTP to the mix soon, as this dopaminergic effect is really powerful and I've still got some "low serotonin" symptoms. I'm actually contemplating declining a new AD from my pdoc in favour of that approach. Do you have any experience of 5HTP?
Posted by Alexanderfromdenmark on April 27, 2009, at 7:18:47
In reply to Re: How long 'til NADH boosts dopamine? » Alexanderfromdenmark, posted by sowhysosad on April 26, 2009, at 19:07:36
> > How did you get codeine?
>
> I just combined 2 over-the-counter meds: 2x ibuprofen/codeine (12.8mg of codeine per tablet), plus 2x paracetamol/codeine (8mg per tablet). That way I didn't exceed the recommended dose for ibuprofen or paracetamol/
>
> > How long time you taken NADH? I've ordered some and quite interested to hear whether it works or whether its another one of those overhyped supplements that dosn't deliver.
>
> This is only my third day and I wasn't expecting it to work so soon but I'm definitely feeling a dopaminergic effect. I've had a tiny bit of caffeine and some nicotine which will boost it, but no more than usual.
>
> The only other factor coming into play is that I quit imipramine only a week ago, so my D2 receptors will still be supersensitive.
>
> It also feels like my dopamine system is "bouncing back" after somehow being suppressed by the imipramine, although the only relevant research I could find claimed tricyclics boost dopamine in some parts of the brain. That's why I originally decided to try one!
>
> However, the atypical features of my depression (oversleeping and binge eating) got progressively worse on imipramine, which woud imply a problem with dopamine.
>
> I'm tempted to drop the NADH dose a little and add a bit of 5HTP to the mix soon, as this dopaminergic effect is really powerful and I've still got some "low serotonin" symptoms. I'm actually contemplating declining a new AD from my pdoc in favour of that approach. Do you have any experience of 5HTP?I have some 5htp, but havn't really used it. I took huge dosage here the other night just to see what it did, and next day i was so fatigued and had a eyelid flutter.
I general after, I quit lexapro and Lyrica my system was been resistant to supplements and meds, where as before I was very sensitive, so I try not to get my hopes too high for NADH. I'm thinking like so many others that I've been left in a hypodopagernic state, but first I'm hoping to get my hormones balanced out, since I've tested low on free testosterone(thanks lexapro) and fT3 since these hormones are crucial to proper brain function, health and it's own production of dopamine.
I must say AD's have caused far more problems than they have solved in my case, but I suppose it's a learning process, if I try an AD again it will be wellbutrin or a dopagernic MAOI.
Have you noticed that dopamine is the new craze here on the board? Everyone want's dopamine! Serotonin makes us numb, NA makes us anxious, but dopamine makes us motivated and fun!
Posted by sowhysosad on April 27, 2009, at 14:36:29
In reply to Re: How long 'til NADH boosts dopamine?, posted by Alexanderfromdenmark on April 27, 2009, at 7:18:47
> Have you noticed that dopamine is the new craze here on the board? Everyone want's dopamine! Serotonin makes us numb, NA makes us anxious, but dopamine makes us motivated and fun!
Yeah no doubt as it's been largely ignored as a target for curing depression over the last 20 years since the advent of SSRI's.
I suppose that'll all change when the first triple uptake inhibitors come to market. The drug companies will quickly remember the importance of their old friend dopamine and the promotional spiel will no doubt underline it.
Posted by Alexanderfromdenmark on April 27, 2009, at 16:14:13
In reply to Re: How long 'til NADH boosts dopamine?, posted by sowhysosad on April 27, 2009, at 14:36:29
> > Have you noticed that dopamine is the new craze here on the board? Everyone want's dopamine! Serotonin makes us numb, NA makes us anxious, but dopamine makes us motivated and fun!
>
> Yeah no doubt as it's been largely ignored as a target for curing depression over the last 20 years since the advent of SSRI's.
>
> I suppose that'll all change when the first triple uptake inhibitors come to market. The drug companies will quickly remember the importance of their old friend dopamine and the promotional spiel will no doubt underline it.
>Yeah check out http://www.mcmanweb.com/dopamine.html
Posted by Alexanderfromdenmark on April 27, 2009, at 16:15:06
In reply to Re: How long 'til NADH boosts dopamine?, posted by Alexanderfromdenmark on April 27, 2009, at 16:14:13
> > > Have you noticed that dopamine is the new craze here on the board? Everyone want's dopamine! Serotonin makes us numb, NA makes us anxious, but dopamine makes us motivated and fun!
> >
> > Yeah no doubt as it's been largely ignored as a target for curing depression over the last 20 years since the advent of SSRI's.
> >
> > I suppose that'll all change when the first triple uptake inhibitors come to market. The drug companies will quickly remember the importance of their old friend dopamine and the promotional spiel will no doubt underline it.
> >
>
> Yeah check out http://www.mcmanweb.com/dopamine.htmlThe thing with the triple uptake inhibors is that they just leave us where we were 50 years ago with the MAOI's, albeit with a difference mechanism
Posted by sowhysosad on April 27, 2009, at 17:22:16
In reply to Re: How long 'til NADH boosts dopamine?, posted by Alexanderfromdenmark on April 27, 2009, at 16:15:06
> The thing with the triple uptake inhibors is that they just leave us where we were 50 years ago with the MAOI's, albeit with a difference mechanism
Well, the drug company's will CLAIM they have less side effects, but to hit all 3 neurotransmitters with a TRI you'll probably have to take quite a hefty dose which will probably create entirely new ones.
It would make more sense just to treat more people with MAOI's, but there's no money to be made in promoting that!
This is the end of the thread.
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