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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by dapper on November 12, 2008, at 1:39:50
This is a question to those who are fairly familiar with receptor action and drugs modes of action. If there was a dietary supplement that worked on seratonin and melatonin, would it even come close to working like agomelatine? Such as something with St. John wort or Sam-E mixed with melatonin? Or is that just a ridiculous concept?
Posted by West on November 12, 2008, at 7:24:57
In reply to Replicating agomelatine?, posted by dapper on November 12, 2008, at 1:39:50
> This is a question to those who are fairly familiar with receptor action and drugs modes of action. If there was a dietary supplement that worked on seratonin and melatonin, would it even come close to working like agomelatine? Such as something with St. John wort or Sam-E mixed with melatonin? Or is that just a ridiculous concept?
Agomelatine must exert its antidepressant effect through 5HT-2c antagonism since its other major action, melatonin agonism, is famously depressogenic.In one trial it was superior to sertraline although in 2006 the EMEA refused to grant license for its use on grounds of efficacy.
SJW is an SNDRI, SamE raises DA, NE and re-releaser of 5-HT. Melatonin is often bad for depressed people.
Posted by desolationrower on November 12, 2008, at 12:22:17
In reply to Re: Replicating agomelatine?, posted by West on November 12, 2008, at 7:24:57
> > This is a question to those who are fairly familiar with receptor action and drugs modes of action. If there was a dietary supplement that worked on seratonin and melatonin, would it even come close to working like agomelatine? Such as something with St. John wort or Sam-E mixed with melatonin? Or is that just a ridiculous concept?
>
>
> Agomelatine must exert its antidepressant effect through 5HT-2c antagonism since its other major action, melatonin agonism, is famously depressogenic.
>
> In one trial it was superior to sertraline although in 2006 the EMEA refused to grant license for its use on grounds of efficacy.
>
>
> SJW is an SNDRI, SamE raises DA, NE and re-releaser of 5-HT. Melatonin is often bad for depressed people.Melatonin is not 'famously depressogenic.' There is some evidence suggesting it worsens depression, and some evidence indicating it helps. It depends on the person, and taking it properly.
As far as replicating, i can't think of any 5ht2c antagonists that are nonpharmaceuticals, but ther are a few drugs, like low doses of ziprasidone or fluoxetine that you could try.
-d/r
Posted by Phillipa on November 12, 2008, at 12:58:40
In reply to Re: Replicating agomelatine?, posted by West on November 12, 2008, at 7:24:57
West melatonin is bad for depression? Didn't know that what's that sleep med that is part melatonin as my pdoc wanted me to try it? Not sonata? Love Phillipa
Posted by Phillipa on November 12, 2008, at 13:00:08
In reply to Re: Replicating agomelatine?, posted by desolationrower on November 12, 2008, at 12:22:17
I wonder what google says about melatonin? Love Phillipa
Posted by dapper on November 12, 2008, at 16:38:30
In reply to Re: Replicating agomelatine? » desolationrower, posted by Phillipa on November 12, 2008, at 13:00:08
Interesting, the melatonin thing I can vouch for with my own experience, as I tried it once to help me sleep. Within 3 or 4 days, it suddenly felt like my AD was being blocked in my brain, like it suddenly stopped working. So out the melatonin went!! Im just curious how its now incorporated into Ago and works so well as an overall drug??
Posted by Negcreep on November 13, 2008, at 3:46:02
In reply to Re: Replicating agomelatine?, posted by dapper on November 12, 2008, at 16:38:30
If you go here you will see the drugs which interact with the same 5-HT receptors as agomelatine.
http://en.wikipedia.org/wiki/5-HT_receptor
So if you took some melatonin along with some LSD, Mescaline,psilocin DMT it might work. The choice is yours lol
Posted by West on November 17, 2008, at 12:16:11
In reply to Re: Replicating agomelatine? » West, posted by Phillipa on November 12, 2008, at 12:58:40
Hi phillipa,
Could be Ramelton, a melatonin agonist.
Posted by Phillipa on November 17, 2008, at 20:03:07
In reply to Re: Replicating agomelatine? Phillipa, posted by West on November 17, 2008, at 12:16:11
West rozeram is it is that the same? Love Phillipa
Posted by West on November 18, 2008, at 5:55:15
In reply to Re: Replicating agomelatine? Phillipa » West, posted by Phillipa on November 17, 2008, at 20:03:07
i think that's it yes.
This is the end of the thread.
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