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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by cumulative on August 30, 2008, at 18:18:07
Like AndrewB, temoigneur, and a few others, memantine as adjunct to my amphetamine has worked well to delay tolerance to the amphetamine's mood-boosting and motivational effects.
I have been using the two together for eight weeks.
I have been doing tremendously well, better than ever, with a great diminishment of my symptoms -- social phobia, anhedonia, loss of motivfation, poor focus, depression, etc.
I can answer questions on this if anyone likes.
It is not a total panacea. I take 40 mg of memantine (30 in the morning, 10 in the evening) and 60mg Vyvanse + 1-2 doses of 5mg dextroamphetamine in the evening. I still notice a little tolerance, although very very little after I added the 10mg evening dose of memantine. Taking one day weekly off works well.
I also take Periactin (cyproheptadine) as a very effective sleep aid.
I have some concerns about a possible loss of cognitive flexibility/creativity and some tendencies towards perseverative behavior with my dextroamphetamine treatment ... I think actually that these are actually less of a problem with nucleus accumbens dopamine release apparently preserved, than they would be without the memantine, but I am considering adding adjunct guanfacine or ... daily low-dose LSD to see if either assists with this.
Posted by eric wagner on August 31, 2008, at 8:48:05
In reply to Memantine + dextroamphetamine is working for me., posted by cumulative on August 30, 2008, at 18:18:07
> Like AndrewB, temoigneur, and a few others, memantine as adjunct to my amphetamine has worked well to delay tolerance to the amphetamine's mood-boosting and motivational effects.
>
> I have been using the two together for eight weeks.
>
> I have been doing tremendously well, better than ever, with a great diminishment of my symptoms -- social phobia, anhedonia, loss of motivfation, poor focus, depression, etc.
>
> I can answer questions on this if anyone likes.
>
> It is not a total panacea. I take 40 mg of memantine (30 in the morning, 10 in the evening) and 60mg Vyvanse + 1-2 doses of 5mg dextroamphetamine in the evening. I still notice a little tolerance, although very very little after I added the 10mg evening dose of memantine. Taking one day weekly off works well.
>
> I also take Periactin (cyproheptadine) as a very effective sleep aid.
>
> I have some concerns about a possible loss of cognitive flexibility/creativity and some tendencies towards perseverative behavior with my dextroamphetamine treatment ... I think actually that these are actually less of a problem with nucleus accumbens dopamine release apparently preserved, than they would be without the memantine, but I am considering adding adjunct guanfacine or ... daily low-dose LSD to see if either assists with this.
Thanks for post.I was looking for such a discussion.
I'm going to my Psychiatrist soon & tell him, again, about the combo.
I am currently on my 9the week of Parnate, currently at 70 mgs./day, w/ no response.
I have tried many different medications over the years.
I was on every form of extended form methylphenidate.
I've never tried instant relief form, as it is probably best I didn't, hearing about the quick feeling & ceasing of symptom relief.
It was the only med., ever, that helped me.
After 2 weeks of the best symptom relief, @ 30 mg./day, & eventually 60 mgs/day, Daytrana's positive effects slowly diminished over the next weeks.
Starting & stopping Daytrana about 5 times, & always experiencing tolerance around the same time.
Eventually trying Concerta, starting at 36 mgs./day & tapering as needed to up to around 108 mgs./day (I think my Dr. may have mistakenly wrote that one prescription dosage so high, as he only prescribed around 20 mgs. Vyvanse, Focalin & Metadate, & with which I had not even near the response of Daytrana.
Adderall XR I found not useful - although my dose may have been too low.
When my Dr. prescribes any of these medications, he always doses low, especially for me, even though I have a huge tolerance for medications & have only responded to stimulants.
I just wish I could find a medical journal to show him about the combo of Memantine & stimulant.
Even though he doesn't really listen to me when I've spoken about materials I bring w/ me to my consultation to him, to possibly help me(As he has stated we are running out of options).
He is very by-the-so-called "results".
I would like to try Memantine, along w/ possibly trying Methylphenidate again or Dexedrine (if I found tolerance also developed).
Daytrana was the best I felt in years, able to work & not be depressed.
The patches are really tough while working, etc. though.
How did you go about talking to your Dr. about the combo.?
The did you mean LSD the psychedelic?
Continued Luck.
Thank You For Your Time & Consideration,
Take Care & Be Well,
Eric M. Wagner
Posted by cumulative on September 1, 2008, at 21:55:05
In reply to Re: Memantine + dextroamphetamine is working for me., posted by eric wagner on August 31, 2008, at 8:48:05
>I am currently on my 9the week of Parnate, currently at 70 mgs./day, w/ no response.
Don't be afraid to increase the dose if you think that would help:
http://www.dr-bob.org/babble/20050827/msgs/548673.html
>Even though he doesn't really listen to me when I've spoken about materials I bring w/ me to my consultation to him, to possibly help me(As he has stated we are running out of options).
Remember, there are always other doctors.
> Daytrana was the best I felt in years, able to work & not be depressed.
I know how you feel. I feel the same way about the initial mood-boosting effects of dextroamphetamine. Finally a solution. I'm doing very well.
>The patches are really tough while working, etc. though.
Yeah, I experienced this while I tried Daytrana. Covering the patch in medical tape seemed to help.
>How did you go about talking to your Dr. about the combo.?
I currently order my memantine from a pharmacy, but am planning to look into a doctor to prescribe it and take over my other prescriptions as well. It may take some time, but I bet I would have luck with someone who specializes in treating treatment-resistant patients. This use of memantine is highly experimental -- I think one avenue that might work is to suggest the memantine as an antidepressant, for which there are a few successful studies you can look up. IIRC the successful antidepressant dose of memantine was 40mg. The posts here may even be good to show, depending on your doctor.
>The did you mean LSD the psychedelic?
Ayep.
>Thank You For Your Time & Consideration,
Take Care & Be Well,
Eric M. WagnerGood luck to you too Eric. I think the memantine is worth a try for someone who finds that the early mood-boost from psychostimulants is great for them, but disappears quickly due to tolerance unless they raise the dose. The memantine has allowed me to keep my dose completely stable. I would recommend anyone interested to search for the posts of andrewb, for instance:
http://www.dr-bob.org/babble/20010714/msgs/70284.html
http://www.dr-bob.org/babble/20010612/msgs/66940.html
Posted by dade on September 4, 2008, at 4:51:07
In reply to Re: Memantine + dextroamphetamine is working for m, posted by cumulative on September 1, 2008, at 21:55:05
I know Amp+ritalin have diferent MOA, but would be good for Ritalin tolerance?
This is the end of the thread.
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