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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Bob on August 9, 2008, at 21:21:25
I've beening seeing increasing posts concerning this cocktail of nortriptyline and zoloft. Does anyone know what the theory would be behind why this might be more effect than something like and SNRI? I'm assuming that Nortriptyline is being used for lack of a better norepinephrine booster, but why Zoloft, of all the SSRI's available? Is it because of the purported domapine effects?
Posted by Phillipa on August 10, 2008, at 0:49:11
In reply to Nortriptyline and Zoloft?, posted by Bob on August 9, 2008, at 21:21:25
The people IRL that I know that take it say it's good for anxiety. Took 50mg myself but didn't up it as the doc never said too. Love Phillipa
Posted by SLS on August 10, 2008, at 5:30:15
In reply to Nortriptyline and Zoloft?, posted by Bob on August 9, 2008, at 21:21:25
> I've beening seeing increasing posts concerning this cocktail of nortriptyline and zoloft. Does anyone know what the theory would be behind why this might be more effect than something like and SNRI?
I would say the hell with theory and just know that it works for some people. For me, it was Effexor that I combined with nortriptyline. It was only partially effective for me, but the response was stable over time. Right now, I have combined nortriptyline with Nardil.
> I'm assuming that Nortriptyline is being used for lack of a better norepinephrine booster,
Yes. You are in agreement with Steven Stahl, MD.
Again, I would work the other way around. Take it now and worry about theory later.
> but why Zoloft, of all the SSRI's available?
It works.
I imagine it would work with any of the SRIs at similar rates. Perhaps Lexapro would be best as it is more selective than the others. Uh, oh. Theory again.
> Is it because of the purported domapine effects?
I am not sure. Possibly. In the same vein, Effexor and probably Pristiq also have DA reuptake inhibition properties.
- Scott
Posted by Bob on August 10, 2008, at 15:39:07
In reply to Re: Nortriptyline and Zoloft?, posted by SLS on August 10, 2008, at 5:30:15
> > I've beening seeing increasing posts concerning this cocktail of nortriptyline and zoloft. Does anyone know what the theory would be behind why this might be more effect than something like and SNRI?
>
> I would say the hell with theory and just know that it works for some people. For me, it was Effexor that I combined with nortriptyline. It was only partially effective for me, but the response was stable over time. Right now, I have combined nortriptyline with Nardil.
>Well, even with theories aside, I'm wondering how prevalent this combo really is out there. It may just be a couple people who've tried it. I did an exhaustive search on the web for it but came up with only a single site - the very site that was linked to on this board.
> > I'm assuming that Nortriptyline is being used for lack of a better norepinephrine booster,
>
> Yes. You are in agreement with Steven Stahl, MD.
>
> Again, I would work the other way around. Take it now and worry about theory later.
>
> > but why Zoloft, of all the SSRI's available?
>
> It works.
>
> I imagine it would work with any of the SRIs at similar rates. Perhaps Lexapro would be best as it is more selective than the others. Uh, oh. Theory again.I wouldn't admonish yourself for using theory in an effort to help with decision making. After all, if you haven't actually tried the combo, then that's all we have.
>
Posted by Bob on August 10, 2008, at 15:39:54
In reply to Re: Nortriptyline and Zoloft?, posted by SLS on August 10, 2008, at 5:30:15
> > I've beening seeing increasing posts concerning this cocktail of nortriptyline and zoloft. Does anyone know what the theory would be behind why this might be more effect than something like and SNRI?
>
> I would say the hell with theory and just know that it works for some people. For me, it was Effexor that I combined with nortriptyline. It was only partially effective for me, but the response was stable over time. Right now, I have combined nortriptyline with Nardil.
>Well, even with theories aside, I'm wondering how prevalent this combo really is out there. It may just be a couple people who've tried it. I did an exhaustive search on the web for it but came up with only a single site - the very site that was linked to on this board.
> > I'm assuming that Nortriptyline is being used for lack of a better norepinephrine booster,
>
> Yes. You are in agreement with Steven Stahl, MD.
>
> Again, I would work the other way around. Take it now and worry about theory later.
>
> > but why Zoloft, of all the SSRI's available?
>
> It works.
>
> I imagine it would work with any of the SRIs at similar rates. Perhaps Lexapro would be best as it is more selective than the others. Uh, oh. Theory again.I wouldn't admonish yourself for using theory in an effort to help with decision making. After all, if you haven't actually tried the combo, then that's all we have.
>
Posted by SLS on August 10, 2008, at 16:05:43
In reply to Re: Nortriptyline and Zoloft? » SLS, posted by Bob on August 10, 2008, at 15:39:54
Have you tried combining Wellbutrin with a SRI? When combined with Zoloft, you get Welloft, a doctor's nick name for this treatment.
Actually, I might have been on a combination of Zoloft and nortriptyline myself. I would have to check my notes. I responded to the addition of Zoloft briefly after being on it for two weeks at 200mg. I have no reason to believe the combination is unsafe.
- Scott
This is the end of the thread.
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