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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by carlton on March 15, 2008, at 12:27:35
I have noticed, in searching this site, a distinction between the "old" nardil and the "new" formulation. Obviously, the pre-2003 formulation was preferred. There may be some placebo effect going on, but maybe not. I realize that a compounding pharmacy cannot recreate the old nardil. However, has anyone had success with a compounding pharmacy in some way modifying nardil such that it has an increased rate of efficacy?
For example, some users report that the new nardil is absorbed more quickly and, apparently, this rapid rate of absorption is deemed to be undesirable, not-beneficial.
Has anyone tried crushing it and filling a capsule that would allow a release in the intestines?
Or, does anyone have information that this sort of theory (shorter release time) is bunk?
Posted by Molybdenum on March 15, 2008, at 20:02:52
In reply to Compounding pharmacies - nardil, posted by carlton on March 15, 2008, at 12:27:35
> I have noticed, in searching this site, a distinction between the "old" nardil and the "new" formulation. Obviously, the pre-2003 formulation was preferred. There may be some placebo effect going on, but maybe not. I realize that a compounding pharmacy cannot recreate the old nardil. However, has anyone had success with a compounding pharmacy in some way modifying nardil such that it has an increased rate of efficacy?
>
> For example, some users report that the new nardil is absorbed more quickly and, apparently, this rapid rate of absorption is deemed to be undesirable, not-beneficial.
>
> Has anyone tried crushing it and filling a capsule that would allow a release in the intestines?
>
> Or, does anyone have information that this sort of theory (shorter release time) is bunk?If the new version is a slow release & they achieve this by coating the granules, then you should be able to speed up absorption by crushing the capsule contents into powder.
If the new one is fast release & you want to slow it down, then couldn't you just divide up the dose into several smaller doses during the day?
Else if you sprinkle the granules into some home made hard sugar candy (ie sugar & water boiled until thick) made into little balls, then there'd be granules near the surface which would be released soon & more granules deeper inside that would take longer to be exposed in the gut & hence dissolve.
It's a pretty inaccurate release mechanism but your post reminded me of something I saw where people with mouth ulcers were being treated with capsaicin. They couldn't tolerate it in the mouth so it was mixed into the hard candy. This apparently worked well for them. :)
Posted by bleauberry on March 16, 2008, at 19:12:10
In reply to Compounding pharmacies - nardil, posted by carlton on March 15, 2008, at 12:27:35
There was talk at another forum a couple months ago about people who had the exact original ingredients for Nardil and had compounding pharmacies work on it, but it wasn't the same. The original just wasn't duplicated for some reason.
I think it was more complicated than just slow release or fast release. Yeah the old was a slower release. But it was more than that. Something about how efficiently it was absorbed.
This is the end of the thread.
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