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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by 4WD on January 15, 2008, at 18:18:26
I can take Provigil (100mg morning and 100mg early afternoon) for a few days and it helps with motivation and energy (though it makes me quite jittery). Then one day I'll take it, all other variables being the same, and instead of helping, it makes me very depressed. If I skip it for a week or so then go back on it, it helps again. But then the cycle repeats itself. I can't understand it.
Any ideas anyone?
Marsha
Posted by Jeroen on January 15, 2008, at 19:46:52
In reply to Why would Provigil act like this? SLS? Anyone?, posted by 4WD on January 15, 2008, at 18:18:26
propably not the right med
i got strange things with the seroquel too
got pooped out, i build a tolerance to itbut i dont beleive that, i think god gave me a candybar for a while, wich i am very gratefull for
apparently he doesnt throw candys when i am hungry :(
Posted by tecknohed on January 15, 2008, at 22:13:01
In reply to Why would Provigil act like this? SLS? Anyone?, posted by 4WD on January 15, 2008, at 18:18:26
Provigil is becoming notorious for quick poopout for many. It happened to me, though it didn't 'cause' any depression like in your case. I think the only way around it is to either take holidays from it (4 days on/4 days off) or rotate it with another mild stim.
teck
Posted by SLS on January 15, 2008, at 22:31:07
In reply to Why would Provigil act like this? SLS? Anyone?, posted by 4WD on January 15, 2008, at 18:18:26
Hi Marsha.
I had the same response pattern as you did with Provigil. In fact, after any antidepressant effect that it produced diminished, came a worsening of depression that lasted two weeks beyond taking the last dose.
Provigil affects two neurotransmitter systems that we don't talk about too much here. It increases the release of glutamate and acts as a hypocretin (orexin) agonist. I think the neurotransmitter most important in the pro-wakefulness properties of Provigil is hypocretin efferents from the hypothalamus. The glutamate release enhancer probably helps out with any antidepressant properties this drug has via dopamine activation in the nucleus accumbens. I haven't been keeping up with research, so I don't know the latest regarding the pharmacology of Provigil.
I don't want to venture a guess as to what's going on with your response pattern to Provigil. There is quite a bit to take into consideration. It is heading towards midnight, and I need to turn my computer off. I'll see what I can come up with tomorrow.
:-)
Oh. It just occurred to me that having a response pattern similar to ours might indicate that Lamictal would be particularly effective as an augmentor of standard antidepressants. Have you tried it yet? At what dosage? How did you respond to it?
- Scott> I can take Provigil (100mg morning and 100mg early afternoon) for a few days and it helps with motivation and energy (though it makes me quite jittery). Then one day I'll take it, all other variables being the same, and instead of helping, it makes me very depressed. If I skip it for a week or so then go back on it, it helps again. But then the cycle repeats itself. I can't understand it.
>
> Any ideas anyone?
>
Posted by 4WD on January 17, 2008, at 13:35:28
In reply to Re: Why would Provigil act like this? SLS? Anyone? » 4WD, posted by SLS on January 15, 2008, at 22:31:07
Hi Scott,
Thanks for answering.
Yes, I tried Lamictal. It helped but I only got up to 50 mg before side effects kicked in. Bad headaches, bad muscle pain and spasms and it made my bottom teeth hurt.
My meds:
Celexa 10-20mg day
Klonopin 4-6 mg day (sometimes as much as 8mg when the anxiety is horrible or if I have taken Provigil)
Geodon 80 mg day
Trazodone 100mg hs
Gabitril 4mg hsProvigil sort of. It helps with motivation and energy but like I said it's a double edged sword. Right now I'm not taking it.
Marsha
Posted by 4WD on January 17, 2008, at 20:37:35
In reply to Re: Why would Provigil act like this? SLS? Anyone? » SLS, posted by 4WD on January 17, 2008, at 13:35:28
Scott, I meant to ask you (but I got so wrapped up in my own troubles, I forgot), if you were posting at midnight, does that mean the Nardil is causing you to have insomnia? I hope not. I mean I know every drug has a side effect (or 20) but insomnia is one of the cruel ones. Here's hoping you were just still up because you were feeling good and not wanting to go to bed yet.Love Marsha
> Hi Scott,
>
> Thanks for answering.
>
> Yes, I tried Lamictal. It helped but I only got up to 50 mg before side effects kicked in. Bad headaches, bad muscle pain and spasms and it made my bottom teeth hurt.
>
> My meds:
>
> Celexa 10-20mg day
> Klonopin 4-6 mg day (sometimes as much as 8mg when the anxiety is horrible or if I have taken Provigil)
> Geodon 80 mg day
> Trazodone 100mg hs
> Gabitril 4mg hs
>
> Provigil sort of. It helps with motivation and energy but like I said it's a double edged sword. Right now I'm not taking it.
>
> Marsha
Posted by SLS on January 18, 2008, at 10:46:50
In reply to Re: Why would Provigil act like this? SLS? Anyone?, posted by 4WD on January 17, 2008, at 20:37:35
Hi Marsha.
> Scott, I meant to ask you (but I got so wrapped up in my own troubles, I forgot), if you were posting at midnight, does that mean the Nardil is causing you to have insomnia?No. However, this is the result of multiple exposures to Nardil and my idiosyncratic brain function.
> I hope not. I mean I know every drug has a side effect (or 20) but insomnia is one of the cruel ones.
I used Ativan to help with sleep whenever Nardil did produce insomnia. There is also trazodone, but you would feel yucky (hangover). Low dosages of Seroquel is another remedy that has shown efficacy. Seroquel has also been shown to produce antidepressant effects with some people, particularly those having bipolar depression.
> Here's hoping you were just still up because you were feeling good and not wanting to go to bed yet.
Yes, indeed.
:-)
Unfortunately, I seem to be in the midst of a plateau and a mild "recession". I prefer to use that word, because it fosters the interpretation of such an increase in depression to be a natural part of the response pattern. It avoids the word "relapse" wherein there is a complete loss of therapeutic effect.
> Love MarshaYou are a sweetie.
Let me know how you have tried to remedy the Nardil-induced insomnia.
- Scott
Posted by 4WD on January 18, 2008, at 19:52:27
In reply to Re: Why would Provigil act like this? SLS? Anyone? » 4WD, posted by SLS on January 18, 2008, at 10:46:50
I'm not on Nardil, just considering it. Scared of it because I hear it makes you gain weight and causes insomnia. I'm a recovering bulimic and I can't afford to be on a med that is going to cause extreme hunger. My brain interprets hunger as "let's go to Winn Dixie and buy fried chicken and double stuffed oreos and eat them all and then throw up."
Also I suffered terribly with insomnia when I was on Prozac for 8-9 years and am terrified of going back to that hell.
Can you really take Trazadone with Nardil? I take Trazadone now, not to fall asleep but to keep from waking up too early.
Marsha
Posted by kingcolon on January 25, 2008, at 2:15:58
In reply to Re: Why would Provigil act like this? SLS? Anyone? » 4WD, posted by SLS on January 15, 2008, at 22:31:07
Here's an article reviewing neuropharm. of Provigil. I haven't bought it, but it looks interesting and up to date.
Posted by SLS on January 25, 2008, at 5:26:21
In reply to Re: Why would Provigil act like this? SLS? Anyone? » SLS, posted by kingcolon on January 25, 2008, at 2:15:58
This is the end of the thread.
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