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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Amigan on December 17, 2007, at 7:08:23
I have observed something which i'm not sure how to explain it:
When i take 20-40mg of prozac i feel the restleness that this drug usually gives. Not akathisia, just restleness. The other day, i took 60mg and i was expecting a greater feeling a restleness to kick in. Instead, i began to yawn and didn't felt any stimulation at all.
Likewise, i'm on moclobemide now (aurorix/manerix) (i have stopped taking prozac) and i take 300-600mg daily which gives me a very subtle stimulation. Yesterday, i took 1200mg and i felt rather groggy. Like i was on a hypnotic. I fell asleep for hours.
Is this an idiosyncratic reaction or it is something common? Is there a pharmacological explanation to this?
Posted by Sigismund on December 17, 2007, at 23:11:19
In reply to Strange reaction on high-dose antidepressants, posted by Amigan on December 17, 2007, at 7:08:23
Maybe the less moclobemide one takes the more stimulating its quality?
I only ever took 75mg/d and that made me feel like I needed a stiff drink at the end of the day.
Do you think the grogginess could be related to what you get from Parnate (not so sure about Nardil), which I guess is about MAO-A inhibition, somehow leading to hypotension?
Posted by amigan on December 18, 2007, at 3:49:27
In reply to Re: Strange reaction on high-dose antidepressants » Amigan, posted by Sigismund on December 17, 2007, at 23:11:19
> Maybe the less moclobemide one takes the more stimulating its quality?
I guess so, but the question is why.
> I only ever took 75mg/d and that made me feel like I needed a stiff drink at the end of the day.
>
> Do you think the grogginess could be related to what you get from Parnate (not so sure about Nardil), which I guess is about MAO-A inhibition, somehow leading to hypotension?Possibly. I did notice a small drop on my BP. But what about prozac? It shouldn't cause hypotension, afaik.
Posted by tecknohed on December 18, 2007, at 7:49:06
In reply to Re: Strange reaction on high-dose antidepressants, posted by amigan on December 18, 2007, at 3:49:27
I also got sedation when I went up on moclobemide. It may have something to do with a particular 5HT receptor, hence why you got it on Prozac too.
Both drugs increase serotonin pretty non-selectively. Maybe at lower doses both drugs increase all serotonin relatively equally, so things are more balanced. But when you increase the dose (of both drugs) one or two particular 5HT receptors (sedating ones) increase thier activity leaving the other receptor sites' activities unchanged, hence increased sedation. Make sense?
I've also found other SSRIs much more sedating than Prozac (paroxetine, citalopram, venlafaxine (low dose)). Perhapse these focus more on the same sedating 5HT sites?
Just a theory.
teck
Posted by amigan on December 19, 2007, at 6:41:24
In reply to Re: Strange reaction on high-dose antidepressants » amigan, posted by tecknohed on December 18, 2007, at 7:49:06
It makes some sense, yes.
This is the end of the thread.
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