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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by iforgotmypassword on February 19, 2007, at 2:50:30
it is supposed to have a ridiculously long half-life. is there some other attribute that makes it short-acting nonetheless?
Posted by Emme on February 19, 2007, at 6:31:42
In reply to why must memantine be taken 2x a day?, posted by iforgotmypassword on February 19, 2007, at 2:50:30
Did your pdoc tell you it had to be taken twice a day? I took it once a day.
emme
Posted by Larry Hoover on February 19, 2007, at 7:20:41
In reply to why must memantine be taken 2x a day?, posted by iforgotmypassword on February 19, 2007, at 2:50:30
> it is supposed to have a ridiculously long half-life. is there some other attribute that makes it short-acting nonetheless?
I just took a look at the uptake and pharmacokinetics, and I can't find even a clue as to why they recommend splitting the dose.
It's a mystery to me.
Lar
Posted by iforgotmypassword on February 19, 2007, at 8:26:51
In reply to Re: why must memantine be taken 2x a day? » iforgotmypassword, posted by Emme on February 19, 2007, at 6:31:42
> Did your pdoc tell you it had to be taken twice a day? I took it once a day.
>
> emmeyep. well he tends to go right by the book. he doesn't like to experiment, and i just come in with idea. i convinced him memantine was harmless, and brought in some articles showing it's use off-label. he looked in his books to see if it was okay, reluctantly agreed, but went with the dosing scheme found in the books.
ironically i do wonder if the recorded half-life of memantine is accurate, when it has been used to treat tardive dyskenesia and benefits were apparently lost 24 hours after discontinuation? the site i found this at is sketchy "patent storm" but i still wonder.
"Discontinuation of memantine resulted in obviously increased dyskinesia within 24 hours, to the point that the movements interfered with reading and musical activities, and caused the patient subjective distress."
http://www.patentstorm.us/patents/5866585-description.html
i don't know, maybe its baloney, trying to be too *sure* of an "invention" on a "patent" website. i don't even get it. does this help or impede the acceptance of drugs being used to treat other things?
gah. i don't know.
thank you for responding! :)
Posted by iforgotmypassword on February 19, 2007, at 8:49:15
In reply to Re: why must memantine be taken 2x a day? » iforgotmypassword, posted by Larry Hoover on February 19, 2007, at 7:20:41
> > it is supposed to have a ridiculously long half-life. is there some other attribute that makes it short-acting nonetheless?
>
> I just took a look at the uptake and pharmacokinetics, and I can't find even a clue as to why they recommend splitting the dose.
>
> It's a mystery to me.
>
> Laryeah, i'm sort of paranoid about it now. every day it seems like recorded medical information is getting less and less concrete (if that's possible.)
i was thinking it could be justification not to make a full dose 20mg pill of the drug, and still charge for two pills in all full dose patients. maybe it's a sneaky tactic to keep it under the standard radar of insurance companies and keep them paying and not questionning the cost, but also makes it tougher for the people like me who are paying cash up front.
but i don't know. it seems both namenda and ebixa are like this... i don't mean to be so suspicious, but it's so expensive and so potentially pointless.
i am paranoid though, over that patent website claim, that effect is lost after 24 hours, since movement crap and persistent leftover akithisic feelings are something i deal with.
http://www.patentstorm.us/patents/5866585-description.html
i don't know about that site, but i think low magnesium may have been the rare state that caused me to be permanently affected by SSRI use. but still i do not know, and there seems to be no reliable test for magnesium, and i wouldn't know the best way to take it. after less than a month of any regime, i am struggling to remember my meds.
btw, i am not taking the memantine 2x a day. i have bunched it into one dose. i would just forget. i guess i am sort of worrying about this...
i think i may try to stay on this drug to try to keep away any antidopaminergic damage if i try amisulpride, if there's any reason to belive 20mg in humans will provide the same protective function it does in rats...
i have no idea how long its supposed to take for memantine to heal away movement problems and a likely broken dopaminergic system. (my chief symptoms are persistent dysthymic inability to do anything, everything takes a ridiculous amount of mental exertion, apathy, lack of ability to enjoy anything, and my thoughts, words, behaviours just do no connect. they are all automatic and show that i am "well" when i am not. in bed most of the day, etc.)
thank you for responding! :)
Posted by rovers95 on February 19, 2007, at 10:05:19
In reply to Re: why must memantine be taken 2x a day? » Larry Hoover, posted by iforgotmypassword on February 19, 2007, at 8:49:15
I took at least 20mg and found no discernable difference how and when i took my dose!!! How are u doing on it???? Personally i found it preety gud for anxiety, is that what u suffer from??!!
mark
Posted by iforgotmypassword on February 19, 2007, at 10:38:26
In reply to Re: why must memantine be taken 2x a day?, posted by rovers95 on February 19, 2007, at 10:05:19
i suffer from "electrified paperweight for a brain syndrome."
anxiety is a problem. i do not go out much for both my inability to do things and my anxiety. social anxiety and spontaneous alone anxiety and rumination. also intermittent outofnowhere RAGE, and obsession over past things, which feels related.
i am taking it for very low functioning, inability to think and do, apathy, inability to articulate and have a mind. like huge chunks of my brain are missing.
Posted by Phillipa on February 19, 2007, at 12:16:12
In reply to Re: why must memantine be taken 2x a day? » rovers95, posted by iforgotmypassword on February 19, 2007, at 10:38:26
Sounds like me. Love Phillipa seriously
Posted by rovers95 on February 20, 2007, at 6:39:32
In reply to Re: why must memantine be taken 2x a day? » iforgotmypassword, posted by Phillipa on February 19, 2007, at 12:16:12
I would recomend it for anxiety, 2 a day to start with n see wot u get, let me know how u get on if u do!!
good luck!!
mark
This is the end of the thread.
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