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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Quintal on January 31, 2007, at 20:55:07
I found an old box of reboxetine the other day and felt like trying a small dose just to see if it helped my fatigue at all. I'm not sure it's a good idea since I had a terrible experience with it last time in combination with Klonopin and tianeptine, but my curiosity has been roused.
Anyone with experiences to share or advice? I notice tensor is also returning to it - how are you finding it?
Q
Posted by Phillipa on January 31, 2007, at 21:18:57
In reply to Edronax (reboxetine) considering re-trial........., posted by Quintal on January 31, 2007, at 20:55:07
Q going to follow your thread and a guy I hope will post a new ad coming on the market. Aske alientari just posted some threads he has a lot of med knowledge. Love Phillipa
Posted by tensor on February 1, 2007, at 10:08:50
In reply to Edronax (reboxetine) considering re-trial........., posted by Quintal on January 31, 2007, at 20:55:07
Yes, after a five weeks trial of Zyban, Remeron and Zoloft my mind was set to retry Edronax with the knowledge that tamsulosin might be an antidote for the horrible s/e I experienced last time (2003), I also found an old box of Edronax with almost 60 pills left. About two weeks ago, I did a sneak trial with Edronax just to remember how it affected me, after two doses, the penis shrinkage returned along with pain in the prostate and the testicles. Also the premature painful(!) ejaculation was there and urinating problems with feeling of residual urine after emptying. Very annoying indeed.
I saw my pdoc a few days ago, and when I had told him the Zyban trial was a failure he asked me if I had any ideas of what to do next. I said I once tried Edronax and responded well to it but had to terminate it because of the above mentioned s/e, he checked the med in a reference book and noticed the s/e was mentioned there. I said I've read studies where subjects on Edronax had been treated successfully, 100% relief, with the alpha1 blocker tamsulosin (naftopidil could work too) and wished to try it. He had no objections to the proposal so I got a prescription of tamsulosin and Edronax.
I started full dose of Edronax at tuesday and felt the symptoms return, Wednesday morning I took one capsule of 0,4mg of tamsulosin and the s/e went away after a few hours. Today I have no s/e from Edronax at all, tamsulosin gives me the usual alpha1-block orthostatic hypotension but that's a trade off I can live with. It's several days left before both meds reach steady state plasma level and several weeks before I can give a fair judgement, but it looks/feels promising. I keep my fingers crossed.
/Mattias
Posted by Quintal on February 1, 2007, at 19:15:05
In reply to Re: Edronax (reboxetine) considering re-trial..... » Quintal, posted by tensor on February 1, 2007, at 10:08:50
Thanks for the post tensor. Can you describe the general 'feel' of the way it's working right now? Speedy, spacey, mind-numbing , blunting etc.?
I remember oozing a bit of semen all day while taking reboxetine the first time, almost as if it was being squeezed out of my prostate by the increased tension there. Did that happen to you?
>I also found an old box of Edronax with almost 60 pills left.
Mine has 33 left left despite the pharmacy dispensing label saying it contains 28. Don't know what happened there........
It's also slightly out of date - went off last October according to the packet but I think it's probably safe enough for a little trial.
The tamsulosin sounds interesting but I don't think I'll be able to get any from my GP unfortunately. I notice depression is one of the side effects of alpha blockers, does it counteract the therapeutic effect of reboxetine in any way? Does it make you feel drowsy? I'm a little vague on the noradrenergic system but I've just bought an excellent book, "Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology)", which should help. It's a little out of date though - published in 2000.
Good luck.
Q
Posted by tensor on February 2, 2007, at 8:31:21
In reply to Re: Edronax (reboxetine) considering re-trial..... » tensor, posted by Quintal on February 1, 2007, at 19:15:05
I'm not really in balance yet, because I still have both Zoloft and Zyban in my system, I quit them last tuesday so it's a bit difficult to say what are withdrawal symptoms and what is contributed by Edronax. Tamsulosin makes me it bit drowsy a few hours after intake but I don't really mind it because it has a more anxiolytic effect rather than depressing. To sum it up, I have a little more energy today but also some "head zaps" from the withdrawal.
>I remember oozing a bit of semen all day while taking reboxetine
Yes, I recognize that, but I haven't noticed it now with tamsulosin. I read an article about tamsulosin that it reduces seminal emission at ejaculation, but I haven't "confirmed" that yet, but it makes sense I think. Don't you get any pain in the prostate/testicles?
>I'm a little vague on the noradrenergic system but I've just bought an excellent book, "Essential..
Yes, the books by Stephen M. Stahl are excellent, I own one myself.
/Mattias
Posted by Quintal on February 3, 2007, at 5:45:25
In reply to Re: Edronax (reboxetine) considering re-trial..... » Quintal, posted by tensor on February 2, 2007, at 8:31:21
It's interesting that you find tamsulosin anixolytic. Do you notice any nasal congestion - I've heard it can be a problem with alpha blockers?
>To sum it up, I have a little more energy today but also some "head zaps" from the withdrawal.
I know what you mean - I had the 'brain rattles' and kaleidoscope vision from Effexor withdrawal. Did you follow a taper schedule?
>Don't you get any pain in the prostate/testicles?
I remember having a chronic low-level ache in my prostate and it would sometimes descend into my testes, as if I'd been kicked in the groin.
>Yes, the books by Stephen M. Stahl are excellent, I own one myself.
Which one did you buy? I notice they had so much enthusiasm for the NARIs back when this was written - predicting they were the missing link that would be a huge leap forward in the treatment of depression. Strattera was undergoing its clinical trials then and still called 'tomoxetine' - they were touting it as a wonder drug.
I've read that reboxetine interacts negatively with codeine and that puts me off a bit because I'm using quite a lot of it now to help with anxiety and depression so that would be a problem. They don't say what the interaction is exactly and information is sparse. Do you know anything about it?
Q
Posted by tensor on February 4, 2007, at 13:16:08
In reply to Re: Edronax (reboxetine) considering re-trial..... » tensor, posted by Quintal on February 3, 2007, at 5:45:25
No, no particular nasal congestion. I have had "The Prescriber's Guide" for a few years. Excellent reference book. The only thing I have found out about reboxetine-codeine interaction is that, via CYP-2D6 inhibition reboxetine could "theoretically" interfere with the analgesic actions of codeine, not so serious I think. I have painkillers that contain codeine and I'm going to use them if needed.
/Mattias
This is the end of the thread.
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