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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by dondon on March 25, 2006, at 17:33:34
I take 300 mgs of sertraline and at this dose it has an amphetamine like effect. I feel great. I can't tolerate 400 mgs but 300 mgs is great. It feels just like dexedrine and adderall did. Zoloft could be considered an SDRI.
Posted by vainamoinen on March 25, 2006, at 23:47:08
In reply to zoloft and dopamine at high doses., posted by dondon on March 25, 2006, at 17:33:34
The only time I've ever gone psychotic was on Zoloft. I'm bipolar II and have a family history of shizophrenia and schizoaffective disorder. Zoloft put me over the edge. Glad it works for you though.
Posted by yxibow on March 26, 2006, at 1:47:30
In reply to zoloft and dopamine at high doses., posted by dondon on March 25, 2006, at 17:33:34
> I take 300 mgs of sertraline and at this dose it has an amphetamine like effect. I feel great. I can't tolerate 400 mgs but 300 mgs is great. It feels just like dexedrine and adderall did. Zoloft could be considered an SDRI.
Zoloft is the only one of the SSRIs that is known to be clinically agonist at some dopamine receptors. There are rare reports of Tardive Dyskinesia and EPS like symptoms with Zoloft.
Posted by ed_uk on March 26, 2006, at 17:42:10
In reply to zoloft and dopamine at high doses., posted by dondon on March 25, 2006, at 17:33:34
Hi
What happened at 400mg?
Ed
Posted by River1924 on March 28, 2006, at 0:18:24
In reply to Re: zoloft and dopamine at high doses. » dondon, posted by ed_uk on March 26, 2006, at 17:42:10
Hi Ed, This is slightly off subject. Wasn't there recent reports in the media of zoloft used at 400 mgs for OCD? River.
(Plus, does anyone know if the company who makes zoloft can extend the patent if a higher dose works for something other than depression? I believe zoloft will become generic in the next year or two in the US.)
Posted by ed_uk on March 28, 2006, at 15:14:31
In reply to Re: zoloft and dopamine at high doses. » ed_uk, posted by River1924 on March 28, 2006, at 0:18:24
Hi River
Sertraline is available as a generic in the UK. Not sure when it will be available as a generic in the US though.
>Wasn't there recent reports in the media of zoloft used at 400 mgs for OCD?
Was it this study......
J Clin Psychiatry. 2006 Jan;67(1):15-22.
High-dose sertraline strategy for nonresponders to acute treatment for obsessive-compulsive disorder: a multicenter double-blind trial.OBJECTIVE: To evaluate the efficacy and safety of high-dose sertraline for patients with obsessive-compulsive disorder (OCD) who failed to respond to standard sertraline acute treatment. METHOD: Sixty-six nonresponders to 16 weeks of sertraline treatment who met DSM-III-R criteria for current OCD were randomly assigned, in a double-blind continuation phase of a multicenter trial, either to continue on 200 mg/day of sertraline or to increase their dose to between 250 and 400 mg/day for 12 additional weeks. Efficacy measures included the Yale-Brown Obsessive Compulsive Scale (YBOCS), the National Institute of Mental Health Global Obsessive Compulsive Scale (NIMH Global OC Scale), and the Clinical Global Impressions-Severity of Illness and -Improvement (CGI-I) scales. Data were collected from July 26, 1994, to October 26, 1995. RESULTS: The high-dose (250-400 mg/day, mean final dose = 357, SD = 60, N = 30) group showed significantly greater symptom improvement than the 200-mg/day group (N = 36) as measured by the YBOCS (p = .033), NIMH Global OC Scale (p = .003), and CGI-I (p = .011). Responder rates (decrease in YBOCS score of > or = 25% and a CGI-I rating < or = 3) were not significantly different for the 200-mg/day versus the high-dose sertraline group, either on completer analysis, 34% versus 52%, or on endpoint analysis, 33% versus 40%. Both treatments showed similar adverse event rates. CONCLUSION: Greater symptom improvement was seen in the high-dose sertraline group compared to the 200-mg/day dose group during continuation treatment. Both dosages yielded similar safety profiles. Administration of higher than labeled doses of selective serotonin reuptake inhibitors may be a treatment option for certain OCD patients who fail to respond to standard acute treatment.
Regards
Ed
This is the end of the thread.
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