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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 21 of 21. This is the beginning of the thread.
Posted by linkadge on March 23, 2006, at 19:34:22
http://www.nature.com/cgi-taf/DynaPage.taf?file=/npp/journal/v28/n2/full/1300036a.html
Linkadge
Posted by rjlockhart on March 23, 2006, at 19:46:03
In reply to SSRI's indirectly influence DAT (negatively ?), posted by linkadge on March 23, 2006, at 19:34:22
intresting article. I need to finish reading, im usally dont read on these things.
what is DAT?
Sorry
A transporter?
Matt
Posted by linkadge on March 23, 2006, at 20:30:59
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 19:46:03
DAT controlls how much dopamine you have in your brain. DAT sucks up dopamine. So less DAT = more doapmine.
Linakdge
Posted by SLS on March 23, 2006, at 20:37:55
In reply to SSRI's indirectly influence DAT (negatively ?), posted by linkadge on March 23, 2006, at 19:34:22
> http://www.nature.com/cgi-taf/DynaPage.taf?file=/npp/journal/v28/n2/full/1300036a.html
>
>
> LinkadgeIt looks like a negative feedback loop to me.
Maybe increased 5-HT inhibitory outflow > reduced DA activation > reduced synaptic DA > upregulation of DAT and postsynaptic receptors = improved DA signal-to-noise ratio?
Perhaps this helps to account for antidepressant discontinuation rebound improvement/mania.
Just a thought.
- Scott
Posted by linkadge on March 23, 2006, at 20:40:18
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by SLS on March 23, 2006, at 20:37:55
Yeah, thats exactly what I was thinking. SSRI withdrawl might lead to a drop in DAT ?
Linkadge
Posted by SLS on March 23, 2006, at 20:40:26
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by SLS on March 23, 2006, at 20:37:55
On second thought, never mind. Dumb idea.
> > http://www.nature.com/cgi-taf/DynaPage.taf?file=/npp/journal/v28/n2/full/1300036a.html
> >
> >
> > Linkadge
>
>
>
> It looks like a negative feedback loop to me.
>
> Maybe increased 5-HT inhibitory outflow > reduced DA activation > reduced synaptic DA > upregulation of DAT and postsynaptic receptors = improved DA signal-to-noise ratio?
>
> Perhaps this helps to account for antidepressant discontinuation rebound improvement/mania.
>
> Just a thought.
>
>
> - Scott
Posted by rjlockhart on March 23, 2006, at 20:42:23
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by linkadge on March 23, 2006, at 20:30:59
so people with not alot of DAT usally have schizophenia?
or alot of people not alot of DAT are ambitious.
Is this a theroy?
Matt
Posted by SLS on March 23, 2006, at 20:43:44
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by linkadge on March 23, 2006, at 20:40:18
> Yeah, thats exactly what I was thinking. SSRI withdrawl might lead to a drop in DAT ?
I don't know what to think. I'm not thinking straight. Too depressed.
- Scott
Posted by SLS on March 23, 2006, at 20:50:35
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » linkadge, posted by SLS on March 23, 2006, at 20:43:44
> I don't know what to think. I'm not thinking straight. Too depressed.
That's no excuse.
I should just pull myself up by my bootstraps!
- Scott
Posted by rjlockhart on March 23, 2006, at 20:51:09
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » linkadge, posted by SLS on March 23, 2006, at 20:43:44
ROFL scott you crack me up..
--I don't know what to think. I'm not thinking straight. Too depressed--
anyways, im still not very smart on this DAT thing but im getting into this..
Matt
Posted by SLS on March 23, 2006, at 20:58:53
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 20:51:09
> ROFL scott you crack me up..
>
> --I don't know what to think. I'm not thinking straight. Too depressed--
>
> anyways, im still not very smart on this DAT thing but im getting into this..
>
> Matt
Actually, your hypothesis regarding schizophrenia make sense logically. Can I borrow your brain for awhile?
- Scott
Posted by rjlockhart on March 23, 2006, at 21:23:50
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » rjlockhart, posted by SLS on March 23, 2006, at 20:58:53
yea that just came to me thinking of it, my brain may have some side effects, but sure. ROFL
Matt
Posted by snapper on March 23, 2006, at 21:24:15
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » rjlockhart, posted by SLS on March 23, 2006, at 20:58:53
sorry to butt in guys but I have to say that DAT is really just noting more than Depressive Attitude Test. There you have it. Cheers!! It really just is another 2,3 or 4 (all caps) acronym) for the way something is or is'nt working in our brains. lol :)
Snapper
Posted by rjlockhart on March 23, 2006, at 21:29:12
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » SLS, posted by snapper on March 23, 2006, at 21:24:15
oh....... i thought it was a transporter.... god i took too much Prozac today.
Thanks
Matt
Posted by snapper on March 23, 2006, at 21:35:01
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 21:29:12
> oh....... i thought it was a transporter.... god i took too much Prozac today.
>
> Thanks
>
> MattMatt
I was just kidding . When my brain feels half way normal, I love to joke around.
snapper
Posted by linkadge on March 23, 2006, at 21:47:48
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » rjlockhart, posted by snapper on March 23, 2006, at 21:35:01
You're right, it is a transporter, I think it is something allong these lines.
After dopamine activates the neuron, DAT transports it away, so that it cannot be used anymore.
At least, thats how I thought it worked.
Yeah, I think there are some studies to see how DAT is expressed in people with schitsohprenia.
I don't know if it came up with anything.
Linkadge
Posted by rjlockhart on March 23, 2006, at 21:55:18
In reply to Re: SSRI's indirectly influence DAT (negatively ?) » rjlockhart, posted by snapper on March 23, 2006, at 21:35:01
ok. Yea more dopamine makes your motivated, want more dopamine. but too much and you will be scared of mircrowaves, and cars that follow you down the road too far, so i do want DAT.
Anything with Prozac making you gullable?
Matt
Posted by Phillipa on March 23, 2006, at 22:23:49
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 21:55:18
Matt do you know the definition of schizophrenia? Google it. You dont need microwave to have schizophrenia. Others see the social board and you'll understand. love Phillipa
Posted by rjlockhart on March 23, 2006, at 22:27:56
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 21:55:18
Oh well i thougt that schizophenia was mainly paranoia, and derailed thinking. So paranoia microwaves are giving out radiation? even thats not rational?
Sorry thats just my put.
Thanks Jan
Matt
Posted by Phillipa on March 24, 2006, at 0:02:44
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by rjlockhart on March 23, 2006, at 22:27:56
Matt microwaves have nothing to do with schizophrenia. That's a delusional of the person writing the thread. Google Love Jan
Posted by Dr. Bob on March 25, 2006, at 11:47:11
In reply to No Matt, posted by Phillipa on March 24, 2006, at 0:02:44
> Matt microwaves have nothing to do with schizophrenia...
Sorry to interrupt, but I'd like to redirect follow-ups regarding microwaves to Psycho-Babble Health. Here's a link:
http://www.dr-bob.org/babble/health/20060202/msgs/624480.html
Thanks,
Bob
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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