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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by overtheedge on November 20, 2005, at 19:10:38
ok so i have looked on this site, and have found what there was to but i still am wondering, bc my dr told me that when they did those studies espicially with people with ED's they over medicated them.....if one were to stay on a Low dose of wellbutrin what are the odds of a seizure? what actually causes them, low eletrolites, lack of food, B/P what are the true risks? i would love to know exactley what the study was? anyone have a clue?
Posted by linkadge on November 20, 2005, at 20:24:48
In reply to wellbutrin and seizures..., posted by overtheedge on November 20, 2005, at 19:10:38
I think the risk is fairly low as long as the dose is low and their is no history of seizures. Antidepressants can lower the seizure threshold by increasing excitory neurotransmission.
Maybe someone can offer more information.
Linkadge
Posted by Phillipa on November 20, 2005, at 20:58:45
In reply to Re: wellbutrin and seizures..., posted by linkadge on November 20, 2005, at 20:24:48
Wish I could! Fondly, Phillipa
Posted by Ilene on November 20, 2005, at 22:46:22
In reply to wellbutrin and seizures..., posted by overtheedge on November 20, 2005, at 19:10:38
Drugs. 2002;62 Suppl 2:45-52.
Tolerability and safety of sustained-release bupropion in the management of smoking cessation.
Aubin HJ.
Centre de Traitement des Addictions, Hopital Emile Roux, 1 Avenue de Verdun, 94456 Limeil-Brevannes, France. [email protected]
Sustained-release bupropion (bupropion SR) was first launched in the US in 1997 as an aid to smoking cessation and has since been launched in many other countries. Adverse events associated with the use of bupropion SR at the recommended dosage of 150mg twice daily in clinical trials most commonly included insomnia, headache, dry mouth, nausea and anxiety; insomnia and anxiety are also recognised as symptoms of nicotine withdrawal. Only insomnia and dry mouth occurred significantly more frequently with bupropion SR than with placebo. Relative to placebo, no significant changes in mean values for heart rate, blood pressure or routine laboratory parameters have been reported in smokers using bupropion SR alone in clinical trials. When bupropion SR was compared with a nicotine transdermal patch in a clinical trial, insomnia predominated in the bupropion SR group, while dream abnormalities were more common in smokers using the nicotine patch. Bupropion SR and the nicotine transdermal patch in combination can be used safely (with appropriate monitoring) as an aid to smoking cessation. Infrequent but clinically important adverse reactions to bupropion SR include seizures and hypersensitivity reactions: in controlled clinical trials of bupropion SR (300 mg/day), where smokers were carefully screened for risk factors for seizure, the incidence of both seizures and severe hypersensitivity reactions was approximately 0.1% for each event. In order to avoid a risk of seizure of greater than 0.1%, smokers should be screened for predisposing risk factors and adhere to the manufacturer's dosage recommendations (maximum daily dose of 300mg). Thus, bupropion SR is generally well tolerated, as seen by the low discontinuation rate due to an adverse event in clinical trials (6 to 12%). The most common adverse events (insomnia and dry mouth) are generally transient and often resolve quickly without therapeutic intervention; they can be managed if necessary by a reduction in bupropion dose.
Posted by Phillipa on November 20, 2005, at 23:01:45
In reply to Re: wellbutrin and seizures... » overtheedge, posted by Ilene on November 20, 2005, at 22:46:22
llene I never could understand how the last hospital I worked at could use this for smoking cessation in the staff. Since it is really wellbutrin and it can create wt loss, anxiety, etc. what did they want to do besides have people quit smoking. Did they ant them to have more energy so they would work more? Fondly, Phillipa
Posted by Ilene on November 20, 2005, at 23:55:40
In reply to Re: wellbutrin and seizures... » Ilene, posted by Phillipa on November 20, 2005, at 23:01:45
I think Wellbutrin is relatively safe. Most people don't experience serious side effects, and it's better for you than smoking.
I.
Posted by overtheedge on November 21, 2005, at 5:28:34
In reply to wellbutrin and seizures..., posted by overtheedge on November 20, 2005, at 19:10:38
Thank you for the replies, that helped but i was looking more for why it is usafe for people with eating disorders? nm the fact you can lose weight or weight nuetral, but what brings on the effects of a seizure with people with an ED....is it the dose? or something else?
Thanks
Posted by Racer on November 22, 2005, at 18:19:41
In reply to Re: wellbutrin and seizures..., posted by overtheedge on November 21, 2005, at 5:28:34
This is only from what my pdoc told me:
EDs have a way of screwing with our body chemistry, which tends to lower the seizure threshold. Wellbutrin also lowers the seizure threshold, which raises the risk too high to use it in someone with an ED.
Yes, it tends to be much more dangerous in those who b/p, but my pdoc said he wouldn't risk it with me unless I was working with an RD to normalize my eating, and even then he'd stop it if he found that I was restricting again. (Yes, he and the RD do communicate.)
How much of a risk is it? That varies according to the studies you look at, but the number I see most often is about 1 in 250 people with have a seizure. That's a fairly high risk, and doctors lose their licenses if they take that sort of risk with patients, so I wouldn't expect your doctor to be willing to try it.
On the other hand, the risk is very much dose and form related: the more med hits your bloodstream at any given time, the greater the likelihood of a seizure. So the sustained or extended release versions are not quite as dangerous as the regular, and very low doses are less dangerous than higher doses. But at this point, there have now been reports of seizures on the XL, too. My pdoc nearly stopped my WB because of that -- pretty good incentive to work on hitting my meal plan.
Posted by overtheedge on November 22, 2005, at 19:17:23
In reply to Re: wellbutrin and seizures... » overtheedge, posted by Racer on November 22, 2005, at 18:19:41
so you take wellbutrin xl? may i ask what dose? do you feel that it is weight neutral? or have lost or have gained, i found with the cymbalta i went on a binge....now i am not to sure if it is bc i was feeling better or bc it was the meds that made me hungry, i understand that everyone reacts diffrent to the same meds one can gain while one can lose.... but what has been your experience with it.....i have an appt tomorrow with my pdoc and want to be prepared, more than normal..lol thanks. Denise
Posted by Racer on November 23, 2005, at 11:05:37
In reply to Re: wellbutrin and seizures...Racer, posted by overtheedge on November 22, 2005, at 19:17:23
My experience... Hm...
I can't tell you anything about weight on it, or on Cymbalta. I've been getting pretty intense treatment for AN, so have gained a lot of weight. I hate it, it's horrible, I will not try to tell you anything else about it. But I know that I'm healthier, and there are some benefits to it, I guess. But as a result, I can't tell what's the nutritional counseling and refeeding, and what's the drugs.
What I know is that I started singing while cooking breakfast one morning a week after starting the WB. I take 300mg.
What sort of treatment are you getting for AN?
Posted by overtheedge on November 24, 2005, at 4:58:48
In reply to Re: wellbutrin and seizures...Racer, posted by Racer on November 23, 2005, at 11:05:37
Racer, for my AN, as you like to call it i like to call it skinny..lol lets see i was put in the hosp against will, in sept refeed, with ensure for 1 1/2 weeks then went on full trays. came home lost it all, see the thing is you need to want to get better....not forced to.BUT there is always a BUT, i do see a ED specialist, bc i am scared if i lose to much husband will take the kids from me, and a pdoc, and now i am on lamictal75 still raising the dose, and topamax, now don't yell, i freaked when i went to 3 digits, so i was able to convince him to give me a script, i know not a good idea....but i need to get back on track, they screwed with me at the hosp, when you refeed someone the hunger comes back and if you are not ready for it it is scary as hell.....ok mso enough of that and i hope there was nothing triggering there for you.if there was please tell me i will delete.i take klonapin 4 mg a day, lets see anything else, oh i see my reg dr everyother week for a weigh in....and the usual an stuff. but now i can go every 3 weeks if i maintain a certain weight. so thats my story......hope it wasn't to long.....i can just ramble.
Posted by overtheedge on November 24, 2005, at 5:23:32
In reply to Re: wellbutrin and seizures...Racer, posted by overtheedge on November 24, 2005, at 4:58:48
> Racer, for my AN, as you like to call it i like to call it skinny..lol lets see i was put in the hosp against will, in sept refeed, with ensure for 1 1/2 weeks then went on full trays. came home lost it all, see the thing is you need to want to get better....not forced to.BUT there is always a BUT, i do see a ED specialist, bc i am scared if i lose to much husband will take the kids from me, and a pdoc, and now i am on lamictal75 still raising the dose, and topamax, now don't yell, i freaked when i went to 3 digits, so i was able to convince him to give me a script, i know not a good idea....but i need to get back on track, they screwed with me at the hosp, when you refeed someone the hunger comes back and if you are not ready for it it is scary as hell.....ok mso enough of that and i hope there was nothing triggering there for you.if there was please tell me i will delete.i take klonapin 4 mg a day, lets see anything else, oh i see my reg dr everyother week for a weigh in....and the usual an stuff. but now i can go every 3 weeks if i maintain a certain weight. so thats my story......hope it wasn't to long.....i can just ramble.
Wanted to add, good for you for getting the help. it must be very hard, but at the same time rewarding.....you must be proud of yourself....
Posted by Racer on November 24, 2005, at 15:04:47
In reply to Re: wellbutrin and seizures...Racer, posted by overtheedge on November 24, 2005, at 5:23:32
> > Racer, for my AN, as you like to call it i like to call it skinny..lol lets see i was put in the hosp against will, in sept refeed, with ensure for 1 1/2 weeks then went on full trays. came home lost it all, see the thing is you need to want to get better....not forced to.BUT there is always a BUT, i do see a ED specialist, bc i am scared if i lose to much husband will take the kids from me, and a pdoc, and now i am on lamictal75 still raising the dose, and topamax, now don't yell, i freaked when i went to 3 digits, so i was able to convince him to give me a script, i know not a good idea....but i need to get back on track, they screwed with me at the hosp, when you refeed someone the hunger comes back and if you are not ready for it it is scary as hell.....ok mso enough of that and i hope there was nothing triggering there for you.if there was please tell me i will delete.i take klonapin 4 mg a day, lets see anything else, oh i see my reg dr everyother week for a weigh in....and the usual an stuff. but now i can go every 3 weeks if i maintain a certain weight. so thats my story......hope it wasn't to long.....i can just ramble.
>
>
> Wanted to add, good for you for getting the help. it must be very hard, but at the same time rewarding.....you must be proud of yourself....
>Oh, la! Not proud at all, and sticking to my meal plan still feels like punishment and failure. I am trying, some days, though -- largely from wanting to make a baby...
The AN rather than 'ana' is just what I said -- "ana" sounds like a cuddly little cutie, you know? Something you might call a stuffed animal...
And I know what you mean about not being able to handle having the hunger thing happen. Even though I voluntarily started treatment, it still freaks me out -- after all those years of hunger being my friend, now it's my enemy. Now it nags at me, so that I can't ignore it the way I used to. It is hard to make that adjustment.
I guess I can't say anything you don't already know about the whole thing, but at least you know you're not alone, right?
Posted by overtheedge on November 24, 2005, at 15:57:41
In reply to Re: wellbutrin and seizures...Racer » overtheedge, posted by Racer on November 24, 2005, at 15:04:47
> > > Racer, for my AN, as you like to call it i like to call it skinny..lol lets see i was put in the hosp against will, in sept refeed, with ensure for 1 1/2 weeks then went on full trays. came home lost it all, see the thing is you need to want to get better....not forced to.BUT there is always a BUT, i do see a ED specialist, bc i am scared if i lose to much husband will take the kids from me, and a pdoc, and now i am on lamictal75 still raising the dose, and topamax, now don't yell, i freaked when i went to 3 digits, so i was able to convince him to give me a script, i know not a good idea....but i need to get back on track, they screwed with me at the hosp, when you refeed someone the hunger comes back and if you are not ready for it it is scary as hell.....ok mso enough of that and i hope there was nothing triggering there for you.if there was please tell me i will delete.i take klonapin 4 mg a day, lets see anything else, oh i see my reg dr everyother week for a weigh in....and the usual an stuff. but now i can go every 3 weeks if i maintain a certain weight. so thats my story......hope it wasn't to long.....i can just ramble.
> >
> >
> > Wanted to add, good for you for getting the help. it must be very hard, but at the same time rewarding.....you must be proud of yourself....
> >
>
> Oh, la! Not proud at all, and sticking to my meal plan still feels like punishment and failure. I am trying, some days, though -- largely from wanting to make a baby...
>
> The AN rather than 'ana' is just what I said -- "ana" sounds like a cuddly little cutie, you know? Something you might call a stuffed animal...
>
> And I know what you mean about not being able to handle having the hunger thing happen. Even though I voluntarily started treatment, it still freaks me out -- after all those years of hunger being my friend, now it's my enemy. Now it nags at me, so that I can't ignore it the way I used to. It is hard to make that adjustment.
>
> I guess I can't say anything you don't already know about the whole thing, but at least you know you're not alone, right?
>FUNNY, i feel so alone..... can i ask you, well let me put it like this, i do not like myself, i would say espically today being thanksgiving i hate myself.....i like alone , i like isolation,i like the thoughts going through my head, but then they get to be to much, and won't stop.....
but for you you will have a baby to look forward to, maybe 2..lol then come and talk to me.....talk about meds then.....
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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