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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by iforgotmypassword on October 28, 2005, at 13:03:37
there seems to be some indication that these drugs are helpful for some people. especially tenex and clonidine.
jay a goldstein seems to imply faith in them in his 'tuning the brain' book, and that they are very overlooked as drugs to improve impaired cognition.
they also discuss them as being able to calm violent thoughts and urges which i would really really like.
i have taken stimulants and they have just caused me to get extremely agitated (especially ritalin), but with certain episodes of help (dexedrine), though completely unreliable that way. i have not tried adderall, but that is extremely hard to track down in my part of canada right now.
Posted by SLS on October 28, 2005, at 13:54:58
In reply to alpha-2 agonists for cognitive clarity, posted by iforgotmypassword on October 28, 2005, at 13:03:37
> there seems to be some indication that these drugs are helpful for some people. especially tenex and clonidine.
Some people are very, very prone to developing depression when taking clonidine.
- Scott
Posted by ed_uk on October 28, 2005, at 15:44:43
In reply to alpha-2 agonists for cognitive clarity, posted by iforgotmypassword on October 28, 2005, at 13:03:37
Clonidine tends to be quite sedating. It's been used as a premedication prior to anesthesia.
~Ed
Posted by sdb on October 28, 2005, at 18:38:05
In reply to alpha-2 agonists for cognitive clarity, posted by iforgotmypassword on October 28, 2005, at 13:03:37
praesynaptic alpha2-agonists e.g clonidine do have anesthesia, blood pressure lowering, sedating properties. It works mainly in Central nervous system in Locus coeruleus (pipmented ganglion cells with long axons), which regulates noradrenaline transmission. It reduces symphatotonicus and has influence on sleep, memory (discussed use for PTSD)
You can take it if you have performance anxiety combined with a betablocker. The weak sedation but especially the diminished noradrenaline transmission will definately not have good properties for cognitive clarity if you mean good effects for saving things in memory, think fastly, etc.
Clonidine will give strange dreams, weak sedation and dry mouth as side effects. After longterm use taper down slowly dosage.
Maybe it will "slow down" your brain thus can even have opposite good effects. It depends of your situation (nervousness, tensioned...)
There are also monoxidine and guanfacine with less sideeffects but I personally do not have experience.
~sdb
Posted by ed_uk on October 28, 2005, at 18:56:04
In reply to Re: alpha-2 agonists for cognitive clarity, posted by sdb on October 28, 2005, at 18:38:05
Hi S,
Moxonidine (Physiotens) is a popular anti-hypertensive in the UK. I don't think it's marketed in the US. Is it popular where you live?
~ed
Posted by sdb on October 29, 2005, at 3:05:57
In reply to Re: alpha-2 agonists for cognitive clarity » sdb, posted by ed_uk on October 28, 2005, at 18:56:04
Hi ed,
moxonidine is not so popular here but it is the only available under the alpha2-agonists.
Betablocker combined with diuretics and for longterm use ACE-inhibitors are mostly used.~sdb
Posted by ed_uk on October 29, 2005, at 14:35:34
In reply to Re: alpha-2 agonists for cognitive clarity, posted by sdb on October 29, 2005, at 3:05:57
Hi S :-)
>Betablocker combined with diuretics and for longterm use ACE-inhibitors are mostly used.
Here, ACE inhibitors, angiotensin antagonists, calcium channel blockers, thiazide diuretics and beta blockers are all much more popular than moxonidine. Nevertheless, moxonidine is still used in those who don't respond to standard treatment.
Kind regards
~ed
Posted by ed_uk on October 29, 2005, at 14:51:04
In reply to Re: alpha-2 agonists for cognitive clarity, posted by sdb on October 29, 2005, at 3:05:57
Hi S,
Bendroflumethiazide 2.5mg is the most popular anti-hypertensive in England. It's very similar to hydrochlorothiazide.
Here is some info RE moxonidine.........
In different animal models, moxonidine (Physiotens) has been shown to be a potent antihypertensive agent. Available experimental data convincingly suggest that the site of the antihypertensive action of Physiotens is the central nervous system (CNS). Within the brainstem, Physiotens has been shown to selectively interact with I1-imidazoline receptors. These imidazoline-sensitive receptors are concentrated in the rostral ventrolateral medulla, an area critical to the central control of the peripheral sympathetic nervous system. The net effect of this interaction with the I1-imidazoline receptor appears to result in a reduced activity of sympathetic nerves (demonstrated for cardiac, splanchnic and renal sympathetic nerves).
Physiotens differs from other available centrally acting antihypertensives by exhibiting only low affinity to central alpha2-adrenoceptors as compared to I1-imidazoline receptors; alpha2-adrenoceptors are considered the molecular target via which sedation and dry mouth, the most common undesired side effects of other centrally acting antihypertensives (eg. clonidine), are mediated.
In humans, Physiotens leads to a reduction of systemic vascular resistance and consequently in arterial blood pressure.
Kind regards
Ed
Posted by sdb on October 30, 2005, at 8:11:08
In reply to Moxonidine » sdb, posted by ed_uk on October 29, 2005, at 14:51:04
Hi ed,
Thanks for your information! It seems to be very similar concerning antihyperensive here.
~sdb
Posted by sdb on October 30, 2005, at 8:38:04
In reply to Re: Moxonidine, posted by sdb on October 30, 2005, at 8:11:08
cardiologie is and is going to be more important in the near future.
We live in a bad (toxic) world. Its similar to a host responding to a virus infection. Inspite of possible coexisting with the virus the host respond to the guest and does harm to itself. But it cannot decide, it is determined. We harm ourself.
~sdb
Posted by ed_uk on October 30, 2005, at 10:21:11
In reply to Re: Moxonidine ed, posted by sdb on October 30, 2005, at 8:38:04
>We harm ourself.
Like an auto-immune disease. Azathioprine is popular here.
Ed
Posted by sdb on October 30, 2005, at 13:34:01
In reply to Re: Moxonidine ed » sdb, posted by ed_uk on October 30, 2005, at 10:21:11
Hi ed!
>>Azathioprine is popular here.
We have this one too and it disrupts the synthesis of DNA, RNA and causing snp's thus more and more poisoned mutants :-)
Relating benzodiazepines we seem to have differences, we have all of them and I think the bz's are more used here than in the uk.
But of course there are still doc's here prescribing TCA's at most...I remember a girl in love crises sent to a psychiatry institute but after treatment suddenly dead. Reason: Heart problem. Father wanted documents. They did not give them out. Father took lawyer. They gave something out.
Fatal heart failure because of aggressive treatment with TCA's?
~sdb
Posted by ed_uk on October 30, 2005, at 13:47:09
In reply to Re: Moxonidine ed, posted by sdb on October 30, 2005, at 13:34:01
Hi S,
Perhaps she had an arrhythmia, induced by the TCA?
Ed
Posted by sdb on October 30, 2005, at 13:50:59
In reply to Re: Moxonidine ed, posted by sdb on October 30, 2005, at 13:34:01
What do you think about trazodone (meaning in the forum, experience)? I have taken this one once and it helped at 50mg daily self treatment during a love crisis pretty fast. People seem to respond very differently to it. It only caused me minor drowsiness after taking it 9 pm.
~sdb
Posted by sdb on October 30, 2005, at 14:00:46
In reply to Re: Moxonidine ed » sdb, posted by ed_uk on October 30, 2005, at 13:47:09
Yes, absolutely possible.
Anyway its a very sad, poor story especially for the father living alone now maybe forever and (professional) medical personal hiding the truth. Very bad things happen to people.
~sdb
> Hi S,
>
> Perhaps she had an arrhythmia, induced by the TCA?
>
> Ed
Posted by ed_uk on October 30, 2005, at 14:27:14
In reply to Re: trazodone ed, posted by sdb on October 30, 2005, at 13:50:59
Hi S
>What do you think about trazodone (meaning in the forum, experience)?
It seems to have aquired a reputation for not being very effective as an AD. Jerrympls said it worked well for him though, the first time he took it. Some people use is as a sleep aid, but it can often make you groggy during the day.
Ed
Posted by sdb on October 30, 2005, at 14:42:51
In reply to Re: trazodone ed » sdb, posted by ed_uk on October 30, 2005, at 14:27:14
and good night!
Posted by iforgotmypassword on October 30, 2005, at 17:27:52
In reply to Re: thanks ed! (nm), posted by sdb on October 30, 2005, at 14:42:51
i'm sort of wondering if my over a year of desipramine has given me permanently high blood pressure and heart rate.
This is the end of the thread.
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