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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by EERRIICC on September 5, 2005, at 20:58:00
Why does parnate (I'm on 150mg a day) cause such strange physical fatigue? I'm out of breath and weak after any sort of exercise!
Posted by willyee on September 5, 2005, at 21:06:55
In reply to Parnate fatigue?, posted by EERRIICC on September 5, 2005, at 20:58:00
Bro your on a very high dose,150 is high,your getting a lot of serotion.
Although its not bad,and can be helpful,150 is still considered a high dose and i too get so tired at a dose near that.
You can try taking a pure caffiene tab.Also did u stop the ritalin.
Posted by EERRIICC on September 6, 2005, at 19:09:54
In reply to Re: Parnate fatigue?, posted by willyee on September 5, 2005, at 21:06:55
Only 120mg and up seems to work. I'm still on ritalin 5mg t.i.d. and hoping to increase it.
Posted by willyee on September 7, 2005, at 6:11:33
In reply to Re: Parnate fatigue? » willyee, posted by EERRIICC on September 6, 2005, at 19:09:54
Keep me/us informed if u can at how ur progress is with rialin.
I already upped it to 10 mg and getting in today to tell my doc i did.
I also have some documented articles on the use of parnate combine with ritalin,about how high the ritalin dose should go,if u havent seen it just let me know.
P.s have u noticed an increase in libido
since adding ritalin,i have.
Posted by Chairman_MAO on September 7, 2005, at 20:30:50
In reply to Parnate fatigue?, posted by EERRIICC on September 5, 2005, at 20:58:00
This is very unusual for your dosage. Did you have more or less fatigue at 90-120mg/day? How about 80mg/day and below?
Have you checked your BP when you feel fatigued? This sounds like hypotension. When I took 200mg/day tranylcypromine, I took 100mg upon rising, then 20mg every three hours thereafter. That provided a good balance between the hypotensive effect of tranylcypromine and the sympathomimetic effect of its metabolites.
How are you taking it? Another strategy you could use __if you can tolerate it__ is to take all 150mg at once in the morning. Within 2-3 hours or so, you'll have enough metabolite formed to feel OK, probably. Do this at your own risk; I am able to tolerate a lot more tranylcypromine than most.When I used to order it from a chemical supply house, I once took 400mg/day in divided doses with EXCELLENT results (on par with Nardil for SP) for a few weeks (no hypomania or any other side effects you'd expect). Unfortunately, I developed severe thrombocytopenia which resolved upon reducing the dose back to 200mg/day. Good thing I was asking my physician to administer certain blood tests--including a platelet count--frequently so I caught that. From now on I'll stick to whatever dose Ivan Goldberg says is the max. ;)
Posted by willyee on September 8, 2005, at 1:12:57
In reply to Re: Parnate fatigue? » EERRIICC, posted by Chairman_MAO on September 7, 2005, at 20:30:50
If chairman remembers i also complained of the same thing.
If my parnate dose was too high i became weak and tired.Also i began to notice a different effect from it.
Oddly more so is the addition of ritlain has not overlapped this problem.
I added a pure caffiene tab,in minutes i felt great,then the caffiene settled in and the edginess came on so i had to deal with that,all in all it was still better than staying fatigued on the parnate.
I know its riddiclous we have to play mad scientist with these damn things.
Chairman how u tolerated a single 100 mg dose rocks my thinking,WOW lol.
Posted by Chairman_MAO on September 9, 2005, at 0:08:35
In reply to Re: Parnate fatigue?, posted by willyee on September 8, 2005, at 1:12:57
I actually can tolerate a 200mg dose no problem whatsoever. Note that this was after I worked up to it, though.
When I first startd the parnate I started right off at 0.7mg/kg, and my BP was arond 160 for a few days until it settled down.
I promise you that if you can push the tranylcypromine to at least 120mg/day (150mg-200mg is more robust), there will be a point at which the sedation is overcome by stimulation. Also, at the high doses TCP downregulates 5ht2, while at normal doses it doesn't. This provides an additional anti-anxiety effect.
This is the end of the thread.
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