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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by willyee on May 10, 2005, at 21:53:53
Hi i was just wondering because i heard this mentioned a few times and would like someone who has a pretty good idea for sure or not if KLONOPIN in any way raises dopamine levels.
Has anyone ever noticed that when you take klonopin in a significantly higher dosage than normal,for me its a whole .5 tab opposed to a nibble of one,but whatever the ase .5 pr 2 mg has anyone noticed when you go higher than usual klonopin usualy seems like a small mind stimulant before it hitys u as a sedative.For example your sedating meds make sense,if you go very high you get sedated and tired,but klonopin seems to act again like a stimulant,i mean it usualy does still knock you out,just not the way youd think the higher dose would.
This just leads to my curiosity on how exactly klonopin effects dopamine,thank you.
Posted by Shawn. T. on May 11, 2005, at 1:09:13
In reply to Benzo Dopamine, posted by willyee on May 10, 2005, at 21:53:53
Klonopin decreases dopamine release in regions of the striatum such as the caudate nucleus due to its inhibition of dopamine neurons in the substantia nigra. It may also decrease dopamine turnover in some regions of the cortex. I was unable to find any information about the effects of Klonopin on dopamine levels in the nucleus accumbens. Valium and other benzodiazepines have been shown to decrease dopamine in this region, so I would assume that Klonopin does as well. The benzodiazepines represent a counterexample to the suggestion that all potentially addictive drugs increase dopamine levels in regions such as the nucleus accumbens.
Shawn
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6152348
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=207628
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7616453
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9181633
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1362661
Posted by SLS on May 11, 2005, at 5:54:24
In reply to Re: Benzo Dopamine, posted by Shawn. T. on May 11, 2005, at 1:09:13
Hi Shawn.
Klonopin actually made me feel more depressed - at least over the first few days that I took it. I discontinued it. Perhaps it would have resolved on its own.
I have read conflicting reports of Klonopin affecting 5-HT function. Are there any putative serotonergic effects that are currently ascribed to it?
- Scott
Posted by BIGDaddyachmed69 on May 11, 2005, at 6:35:29
In reply to Re: Benzo Dopamine » Shawn. T., posted by SLS on May 11, 2005, at 5:54:24
> I have read conflicting reports of Klonopin affecting 5-HT function.
Doesn't Xanax affect 5-HT function?
Posted by Shawn. T. on May 11, 2005, at 12:18:54
In reply to Re: Benzo Dopamine » Shawn. T., posted by SLS on May 11, 2005, at 5:54:24
Klonopin may decrease serotonin turnover in the raphe nucleus and hippocampus. I personally think that the effects of benzodiazepines are mediated for the most part by mechanisms that do not involve monoamines.
Shawn
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1723798
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7689737
Posted by Shawn. T. on May 11, 2005, at 12:40:38
In reply to Re: Benzo Dopamine, posted by BIGDaddyachmed69 on May 11, 2005, at 6:35:29
It increases serotonin release in rats under chloral hydrate anesthesia. I found some other articles, but I wasn't sure what to conclude from them so I'll leave it at that.
Shawn
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9421826
Posted by BIGDaddyachmed69 on May 11, 2005, at 13:23:22
In reply to Re: Benzo Dopamine » BIGDaddyachmed69, posted by Shawn. T. on May 11, 2005, at 12:40:38
> It increases serotonin release in rats under chloral hydrate anesthesia. I found some other articles, but I wasn't sure what to conclude from them so I'll leave it at that.
>
> Shawn
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9421826That's an interesting study. I always wondered why Xanax felt different than other benzos. I read that it increased serotonin release at another website, but there was nothing there to back that up.
Posted by Shawn. T. on May 11, 2005, at 19:12:13
In reply to Re: Benzo Dopamine, posted by BIGDaddyachmed69 on May 11, 2005, at 13:23:22
Here's another intriguing study about Xanax (alprazolam):
Shawn
Posted by willyee on May 11, 2005, at 19:39:41
In reply to Re: Benzo Dopamine, posted by Shawn. T. on May 11, 2005, at 1:09:13
> Klonopin decreases dopamine release in regions of the striatum such as the caudate nucleus due to its inhibition of dopamine neurons in the substantia nigra. It may also decrease dopamine turnover in some regions of the cortex. I was unable to find any information about the effects of Klonopin on dopamine levels in the nucleus accumbens. Valium and other benzodiazepines have been shown to decrease dopamine in this region, so I would assume that Klonopin does as well. The benzodiazepines represent a counterexample to the suggestion that all potentially addictive drugs increase dopamine levels in regions such as the nucleus accumbens.
Thanks dont know where i thought i heard it increased dopamine,thanks for the through answer and links
>
> Shawn
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6152348
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=207628
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7616453
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9181633
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15680263
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1362661
Posted by Chairman_MAO on May 11, 2005, at 20:19:26
In reply to Benzo Dopamine, posted by willyee on May 10, 2005, at 21:53:53
"Paradoxical stimulation" is common with benzodiazepines. It is a result of what is called disinhibition, viz. gaba-a stimulation results in an indirect increase in some neurotransmission elsewhere in the ol' dog's breakfast (Kurt Vonnegut's deliciously sarcastic term for the brain). I wish I knew more about this offhand, but I don't, and I'm too lazy to look it up right now. ;)
Posted by Phillipa on May 11, 2005, at 20:22:26
In reply to Re: Benzo Dopamine » willyee, posted by Chairman_MAO on May 11, 2005, at 20:19:26
Klonopin made me feel suicidal the first time I took it and the pdoc said to stop and go back on xanax. That was a long time ago. I've taken it since and it made me feel stupid. I do remember the first pdoc saying to himself as he returned my call that the klonopin can cause depression. fondly, Philllpa
Posted by SLS on May 12, 2005, at 7:28:55
In reply to Re: Benzo Dopamine » SLS, posted by Shawn. T. on May 11, 2005, at 12:18:58
> Klonopin may decrease serotonin turnover in the raphe nucleus and hippocampus. I personally think that the effects of benzodiazepines are mediated for the most part by mechanisms that do not involve monoamines.
Clonazepam is somewhat of a black-sheep, though. It possesses therapeutic properties that are unique to the BZDs. I am just wondering if the 5-HT properties don't confer its anti-manic, mood-stabilizing and occasional depressogenic effects.
- Scott
Posted by BIGDaddyachmed69 on May 12, 2005, at 12:20:18
In reply to Re: Benzo Dopamine » Shawn. T., posted by SLS on May 12, 2005, at 7:28:55
> Clonazepam is somewhat of a black-sheep, though. It possesses therapeutic properties that are unique to the BZDs. I am just wondering if the 5-HT properties don't confer its anti-manic, mood-stabilizing and occasional depressogenic effects.
>
>
> - ScottIf Klonopin does affect 5-HT function, how come Xanax (which positively has an effect on 5-HT) tends to alleviate depression? Klonopin causes it in some people, right? I'm confused about how the two affect the neurotransmitter, but I guess that COULD be responsible. In my opinion, the extent to which these benzos affect it is negligible. Otherwise, my pdoc would not allow me to take Xanax with an MAOI. He'd prefer I didn't take it but for other reasons...
Posted by Chairman_MAO on May 12, 2005, at 21:04:59
In reply to Re: Benzo Dopamine, posted by BIGDaddyachmed69 on May 12, 2005, at 12:20:18
AFAIK, xanax affects NE, not SE. Am I right?
Posted by pro_social_soon on May 13, 2005, at 6:55:37
In reply to Re: Benzo Dopamine » BIGDaddyachmed69, posted by Chairman_MAO on May 12, 2005, at 21:04:59
> AFAIK, xanax affects NE, not SE. Am I right?
I think Xanax releases 5-HT
This is the end of the thread.
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