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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by FredPotter on April 10, 2005, at 18:16:47
A few years ago there was a discussion about the beneficial effects of augmenting ADs with Naltrexone. The usual dose for blocking opiates and alcohol treatment is 50mg, but the augmentation dose for depression back then was usually 25mg.
Since this time, LDN has become popular for the treatment of various things, but principally MS. The idea is roughly this I think. Between 2am and 4am we produce our daily quota of endorphines and a low dose of naltrexone blocks the receptors during this process, thus releasing more for the rest of the day. Its apparently beneficial for the auto-immune system (although there's so much said about the immune system I get wary of claims).
It seems like this approach might be beneficial for depression, especially as many people are finding opiates helpful, when used carefully.
Any ideas?
Fred
Posted by The_Resistance on April 11, 2005, at 6:11:20
In reply to Low Dose Naltrexone (LDN), posted by FredPotter on April 10, 2005, at 18:16:47
I remeber reading this account in a newspaper, it was writen by an ex herion addict.
He said Natrexone made him feel good, if I remeber corretly.It sounds interesting, I've never heard of it being used as an AD before.
Posted by Paulbwell on April 11, 2005, at 9:32:15
In reply to Low Dose Naltrexone (LDN), posted by FredPotter on April 10, 2005, at 18:16:47
Does N have anti Dep effects? fred?
Posted by JKL on April 11, 2005, at 19:03:34
In reply to Low Dose Naltrexone (LDN), posted by FredPotter on April 10, 2005, at 18:16:47
I tried naltrexone with prozac. It supposedly works best as an AD augmentor, and works best with prozac. Some unknown link between the serotonin system and the opioid system. There was one guy who had great results with it. But I remember a handful of other people including myself who didn't get much out of it.
Intense nausea is an initial side effect that is tough to get through. Had to break a 25mg dose into chunks, and do just a small chunk. Eventually the nausea passed, got up to 50mg. Noticed a little more calmness and composedness in public, but no real antidepressant effect and no pro-motivation effect.
I was out to dinner and was looking forward to a glass of wine, because I rarely drink, and when I do it only takes a little to get me feeling good. I was looking forward to that little buzz from the wine. Two glasses later, no buzz. I had forgotten about the naltrexone. It blocked the alcohol buzz.
It either works great or it doesn't. Just like them all. :-(
Posted by JayDee on April 11, 2005, at 22:37:22
In reply to Re: Low Dose Naltrexone (LDN), posted by JKL on April 11, 2005, at 19:03:34
50mg is not LDN. LDN involves taking ~3mg(yes less then 1/10th what you were taking) at night before bed to upregulate opiod receptors. the low dose is to insure the naltrexone is OUT of your system during the day.
Posted by FredPotter on April 12, 2005, at 16:10:11
In reply to Re: Low Dose Naltrexone (LDN) » JKL, posted by JayDee on April 11, 2005, at 22:37:22
That's what I meant to say but didn't. This tiny dose must also not be sustained release. It needs to be out of the system by morning
This is the end of the thread.
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