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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by ravenstorm on February 2, 2005, at 10:40:49
side effects? efficacy? effects on anxiety?
Hope you are doing well!
Posted by emme on February 2, 2005, at 14:44:12
In reply to emme, how is the memantine trial going?, posted by ravenstorm on February 2, 2005, at 10:40:49
Okay, memantine update:
Pluses:
- decreased depression, less hopeless.
- less apathetic.
- not too anxious in general. Less mental anxiety.Minuses:
- *Wicked* tired and and not concentrating that well.
- Sometimes a little overstimulated despite the fatigue - but not all the time. Not really the same thing as anxiety. Sometimes sluggish.
- Constant sense of being a little outside of my body (derealization?) It's annoying, but not extreme. I'm waiting to see if it'll fade.Neutral:
I seem to be kind of detached from my feelings. It's nice to be separated from the intense depression and anxiety and having a bit of a break may allow you to get things done. Again, waiting to see how it pans out.Conclusions:
Give it a whirl. It's definitely having some positive effects. I'm not sure I'm tolerating it that well physically and I want to drop the dose. Remember, I am very sensitive to drugs and I have had worse side effects on lots of other drugs. So you might find it very benign.
> side effects? efficacy? effects on anxiety?
>
> Hope you are doing well!
Posted by SadDoggie on February 2, 2005, at 18:09:08
In reply to Re: emme, how is the memantine trial going? » ravenstorm, posted by emme on February 2, 2005, at 14:44:12
I'm glad to see someone trying memantine. You can try to get your psychiatrist to add in adderall or dexedrine (or get a hold of it yourself) and see if you feel better. As they are amphetamines they will definitely make you feel less fatigued and make you concentrate better. And the memantine they say may prevent tolerance from developing to the amphetamine.
Good Luck,
SadDoggie
> Okay, memantine update:
>
> Pluses:
> - decreased depression, less hopeless.
> - less apathetic.
> - not too anxious in general. Less mental anxiety.
>
> Minuses:
> - *Wicked* tired and and not concentrating that well.
> - Sometimes a little overstimulated despite the fatigue - but not all the time. Not really the same thing as anxiety. Sometimes sluggish.
> - Constant sense of being a little outside of my body (derealization?) It's annoying, but not extreme. I'm waiting to see if it'll fade.
>
> Neutral:
> I seem to be kind of detached from my feelings. It's nice to be separated from the intense depression and anxiety and having a bit of a break may allow you to get things done. Again, waiting to see how it pans out.
>
> Conclusions:
> Give it a whirl. It's definitely having some positive effects. I'm not sure I'm tolerating it that well physically and I want to drop the dose. Remember, I am very sensitive to drugs and I have had worse side effects on lots of other drugs. So you might find it very benign.
>
>
> > side effects? efficacy? effects on anxiety?
> >
> > Hope you are doing well!
>
>
Posted by emme on February 2, 2005, at 18:14:55
In reply to Re: emme, how is the memantine trial going?, posted by SadDoggie on February 2, 2005, at 18:09:08
Actually, I'm already trying a little focalin for the fatigue. Sometimes it helps a little. Sometimes I feel too racey on it and just end up tired/wired. My pulse is up a little on the memantine already, though not severely. I'm left very tired when the focalin wears off and, obviously, I don't want to take another dose too late in the day. So, I haven't yet gotten a feel for how to manage this.
> I'm glad to see someone trying memantine. You can try to get your psychiatrist to add in adderall or dexedrine (or get a hold of it yourself) and see if you feel better. As they are amphetamines they will definitely make you feel less fatigued and make you concentrate better. And the memantine they say may prevent tolerance from developing to the amphetamine.
>
> Good Luck,
>
> SadDoggie
>
> > Okay, memantine update:
> >
> > Pluses:
> > - decreased depression, less hopeless.
> > - less apathetic.
> > - not too anxious in general. Less mental anxiety.
> >
> > Minuses:
> > - *Wicked* tired and and not concentrating that well.
> > - Sometimes a little overstimulated despite the fatigue - but not all the time. Not really the same thing as anxiety. Sometimes sluggish.
> > - Constant sense of being a little outside of my body (derealization?) It's annoying, but not extreme. I'm waiting to see if it'll fade.
> >
> > Neutral:
> > I seem to be kind of detached from my feelings. It's nice to be separated from the intense depression and anxiety and having a bit of a break may allow you to get things done. Again, waiting to see how it pans out.
> >
> > Conclusions:
> > Give it a whirl. It's definitely having some positive effects. I'm not sure I'm tolerating it that well physically and I want to drop the dose. Remember, I am very sensitive to drugs and I have had worse side effects on lots of other drugs. So you might find it very benign.
> >
> >
> > > side effects? efficacy? effects on anxiety?
> > >
> > > Hope you are doing well!
> >
> >
>
>
Posted by SLS on February 11, 2005, at 15:44:31
In reply to Re: emme, how is the memantine trial going? » SadDoggie, posted by emme on February 2, 2005, at 18:14:55
Hi.
I've decided to give memantine another try.
I doubt it will help, but since I'd be combining it with Parnate this time, who knows? I'm starting right at 20mg. If you don't here from me over the next few day, it will be because I either dropped dead or am out chasing women.
- Scott
Posted by emme on February 12, 2005, at 23:51:38
In reply to Re: emme, how is the memantine trial going? » emme, posted by SLS on February 11, 2005, at 15:44:31
Hi.
> I've decided to give memantine another try.Good luck! I hope it helps.
> I doubt it will help, but since I'd be combining it with Parnate this time, who knows? I'm starting right at 20mg. If you don't here from me over the next few day, it will be because I either dropped
> .... out chasing women.Chasing women as a possible side effect of that drunken feeling you mentioned? :) Don't get into any brawls.
Keep us posted. I'm feeling my way at 7.5 mg at the moment. I think I'm still waiting for the dose change to show. I really wish this drug had a shorter half life.
em
Posted by ed_uk on February 13, 2005, at 7:49:25
In reply to Re: emme, how is the memantine trial going? » emme, posted by SLS on February 11, 2005, at 15:44:31
Hi Scott!
>I've decided to give memantine another try.
Good idea, could be a good combination with Parnate :-)
>I'm starting right at 20mg.
I thought you felt 'drunk' at that dose, maybe you'd actually get a better AD effect at a lower dose. What do you think?
Btw, do you think you'll try Parnate + imipramine again? Was this combination any more effective than Parnate + nortriptyline?
Best of Luck,
Ed.
Posted by SLS on February 13, 2005, at 8:16:29
In reply to Re: emme, how is the memantine trial going? » SLS, posted by ed_uk on February 13, 2005, at 7:49:25
Hi Ed.
> I thought you felt 'drunk' at that dose, maybe you'd actually get a better AD effect at a lower dose. What do you think?
It was at 40mg that I experienced the state of feeling intoxicated. I actually experienced a significant antidepressant effect the first time at 20mg. The response lasted for about a week or so before pooping-out on me. I was so sure I hit the bullseye that time. Since memantine had been so different from the monoaminergic drugs I tried in the past, I figured it had a good chance of "sticking". Crap.
> Btw, do you think you'll try Parnate + imipramine again? Was this combination any more effective than Parnate + nortriptyline?I gleaned a long-term response (9 months) from Parnate + desipramine in 1987. The same combination does very little for me now. Parnate + nortriptyline does as much for me as the imipramine combo, but is more forgiving cognitively. For now I prefer nortripyline. I am using the combo as an old recipe that represents a dead-end but that allows me to function well enough to take care of life's essentials and maintain an apartment.
ARGH! (frustration and anger)
Thanks for caring, Ed.
- Scott
Posted by ravenstorm on February 13, 2005, at 23:23:04
In reply to Re: emme, how is the memantine trial going?, posted by SLS on February 13, 2005, at 8:16:29
Posted by ravenstorm on February 13, 2005, at 23:29:10
In reply to Re: emme, how is the memantine trial going? (nm), posted by ravenstorm on February 13, 2005, at 23:23:04
Somehow, my post got messed up. Scott, I meant to say how great it is that you can keep your sense of humour through all of this.
I vote for chasing women!! All fingers and toes crossed for you!
This is the end of the thread.
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