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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by elizabeth22 on January 6, 2005, at 16:35:33
Hi, just wondering if anyone could tell me a bit about noradrenaline, if there has been any research into 'noradrenaline deficiency' and if so, what such a deficiency looks like... Also, is there any physical illness (apart from depression!) that can reduce your levels of NA?
I'm wondering because I've just recently started taking Remeron for depression - it's the first time i've taken a drug which affects noradrenaline and I'm finding a definite difference from the SSRIs I've taken in the past (which don't do much for me). It's not really affecting my mood so much, but I just feel as if I'm functioning. It's a nice feeling, as I'm not feeling numb as I did on the SSRIs, just 'normal' and as if I can understand things that have happened in my life better, that I've got a slightly better perspective (or maybe this is just a delusion...). I can also concentrate a lot better, and this is reducing my anxiety e.g. if I feel worried about something, I can get lost in a book and forget about my worries, whereas before I couldn't read at all - I was almost on constant alert as I was so anxious. On the other hand, if I think about something upsetting, this also seems more real, so, weirdly, I have been feeling sad more often than when I was 'depressed'. When I was very depressed, I felt detached from everything but also very worried. I'm glad to have my emotions back, but it's a bit of a shock to the system - my life just feels a lot more real to me somehow and obviously there are going to be some downsides to this...
Anyway, sorry, I'm just rambling now but am wondering if anyone has experienced the same kind of thing with remeron or drugs that affect NA - I'd like to hear any experiences you have had.
Thanks
Posted by linkadge on January 6, 2005, at 18:10:33
In reply to remeron/effects on noradrenaline, posted by elizabeth22 on January 6, 2005, at 16:35:33
Adrenal problems can cause norepinephrine irregularities.
Remeron is a much better drug on the HPA axis than the SSRI's. (it seems to significantly regulate the stress responce system) Remeron also increases noradrenic neurotransmission, which may be decreased in depression and some other diseases. (Parkinsons ADHD)
Noradrenaline is inolved in mood, arousal, alertness, concentration, and normal anxiety responces.
I had it explained to me in this way. Noradrenaline is involved in thinking about and planning for the future. Noradrenic meds can have antianxiety/antipanic effects (which take a while to work), in the sence that through this type of thought, we can become more mentally prepared for potential stressors.
Noradrenic meds can increase anxiety at first, since they often "alert" you to your problems which can cause inital anxiety.
Linakdge
Posted by King Vultan on January 7, 2005, at 17:23:12
In reply to remeron/effects on noradrenaline, posted by elizabeth22 on January 6, 2005, at 16:35:33
Remeron also has a very strong effect on blockading serotonin-2A receptors, which does have some anti-anxiety benefits, among other things. It winds up having effects on both serotonin and norepinephrine, but via a very different process than drugs like Effexor or Cymbalta do.
Todd
Posted by elizabeth22 on January 8, 2005, at 6:35:16
In reply to Re: remeron/effects on noradrenaline, posted by linkadge on January 6, 2005, at 18:10:33
Hi Linkadge, thanks for your reply. It's very intersting to know that adrenal problems can cause norepinephrine irregularities as I've suspected i might have that problem. Have you taken remeron before and did you find it helpful?
> Adrenal problems can cause norepinephrine irregularities.
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> Remeron is a much better drug on the HPA axis than the SSRI's. (it seems to significantly regulate the stress responce system) Remeron also increases noradrenic neurotransmission, which may be decreased in depression and some other diseases. (Parkinsons ADHD)
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> Noradrenaline is inolved in mood, arousal, alertness, concentration, and normal anxiety responces.
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> I had it explained to me in this way. Noradrenaline is involved in thinking about and planning for the future. Noradrenic meds can have antianxiety/antipanic effects (which take a while to work), in the sence that through this type of thought, we can become more mentally prepared for potential stressors.
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> Noradrenic meds can increase anxiety at first, since they often "alert" you to your problems which can cause inital anxiety.
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> Linakdge
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Posted by elizabeth22 on January 8, 2005, at 6:43:53
In reply to Re: remeron/effects on noradrenaline, posted by King Vultan on January 7, 2005, at 17:23:12
Posted by borderliner on January 9, 2005, at 3:24:12
In reply to remeron/effects on noradrenaline, posted by elizabeth22 on January 6, 2005, at 16:35:33
I found the sedating effects of Remeron to be too much. I eventually just felt like a tub of jelly all day. i had the same experience with SSRI's and bad experiences with SNRI's. I am finding comfort in Reboxetine- an NARI which only effects NA and nothing else. Has increased my alertness and concentration but somehow reduced my anxiety. I dont know how but its damn good so far.
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Posted by elizabeth22 on January 15, 2005, at 5:49:29
In reply to Re: remeron/effects on noradrenaline » elizabeth22, posted by borderliner on January 9, 2005, at 3:24:12
Hello, sorry for the delay in replying to your message. Just wanted to say thanks - your experience makes me feel hopeful as I hope eventually to change from Remeron to something like Reboxetine, as hopefully it will have fewer side-effects. I was worried that it would make me anxious, but if that didn't happen to you maybe it won't!
thanks again,
Elizabeth xx
> I found the sedating effects of Remeron to be too much. I eventually just felt like a tub of jelly all day. i had the same experience with SSRI's and bad experiences with SNRI's. I am finding comfort in Reboxetine- an NARI which only effects NA and nothing else. Has increased my alertness and concentration but somehow reduced my anxiety. I dont know how but its damn good so far.
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