Psycho-Babble Medication Thread 434568

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Tramadol (Ultram) and grapefruit juice

Posted by BradD on December 27, 2004, at 10:15:33

Hello
I have a question. Is there any interaction between taking Tramadol with grapefruit juice? Is Tramadol metabolized by enzyme 3A4 ? I know that grapefruit juice affects alprazolam (Xanax) and diazepam (Valium), but I'm wondering about Tramadol (Ultram) since I use it for my social phobia with great results.

Take care
Brad

Re: Tramadol (Ultram) and grapefruit juice » BradD

Posted by Larry Hoover on December 27, 2004, at 22:24:56

In reply to Tramadol (Ultram) and grapefruit juice, posted by BradD on December 27, 2004, at 10:15:33

> Hello
> I have a question. Is there any interaction between taking Tramadol with grapefruit juice? Is Tramadol metabolized by enzyme 3A4 ? I know that grapefruit juice affects alprazolam (Xanax) and diazepam (Valium), but I'm wondering about Tramadol (Ultram) since I use it for my social phobia with great results.
>
> Take care
> Brad

Tramadol has an active metabolite via the enzyme 2D6. As far as I know, that's it. Sorry, grapefruit will not affect this drug.

Lar

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