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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by 3 Beer Effect on October 29, 2004, at 20:17:04
I have been taking Eldepryl/L-Deprenyl/Selegeline for about 3 weeks now. It took about 10 days to start working, but now seems to be making social anxiety worse, in a manner similar to that caused by Ritalin where I have an excessive amount of self-consciousness.
I was sure Selegeline would be the answer to cure Social Phobia because there is a dopaminergic theory of social phobia & because I used to take Dextrostat(d-amphetamine) or even street methamphetamine both of which helped greatly with social phobia. Why would amphetamines (which also release the bad norepinephrine in addition to dopamine) help with social phobia but selegeline (which exclusively increases dopamine) cause anxiety/social phobia?
Also, I take DLPA 500 mg every morning. I was sure that DLPA, since it converts to PEA when you are taking Selegeline, would cause a glorious Dextrostat feeling but it mainly causes dysphoria, nervousness & slight paranoia. What gives?
I am thinking of ditching the Selegeline & after a 2 week washout period, switching to a low dose of generic Prozac (10 mg) since SSRIs do seem to be the only drugs besides alcohol (the best) & amphetamines (2nd best) to have any real effects on sociability. But, when I was in college on Zoloft 100 mgs I almost failed myself out of school because SSRIs seem to diminish your short term memory (& after a few months I became manic) & since my job is intellectually demanding, taking a dumb drug could get me fired.
3 Beer Effect
Posted by jboud24 on October 29, 2004, at 21:02:20
In reply to L-Deprenyl/Selegeline make Social Phobia worse?, posted by 3 Beer Effect on October 29, 2004, at 20:17:04
How much deprenyl are you taking? Maybe you should also try lowering the dose of dlpa. Also, deprenyl metabolized into l-amphetamine and l-methamphetamine which act on norepinephrine much more so than their dextro counterparts. Although it is also suppossed that the l-amp and l-meth metabolites contribute to the pharmacology of deprenyl. I'd definitely try playing with the doses though.
Good luck with your combo,
Justin
Posted by Mindreseacher on October 29, 2004, at 23:34:24
In reply to Re: L-Deprenyl/Selegeline make Social Phobia worse, posted by jboud24 on October 29, 2004, at 21:02:20
Another aspect in which you are not achieving the socialness that your experienced on dexedrine and methampetamine, is that, and esp. meth, realeases Larger amounts of Dopamine from the nucleaus accumbens. ALso, meth releases seratonin, not as much as extacy, but a decent amount.
I often wonder, neurchemically, what other medications besides adderall, d-amphetamine, Meth, opiates, release dopamine from the Nucleaus accumbens? Oh cocaine also. Each from my point of view all act on the mesolibic dopaminergic system, unlike welbutrin, straterra,or other dopaminergic/Na drugs, which release it not from there, but other regions.
I also wondered if natural dopaminergic mixures, would help release da from the Nucleus shell. But thats a far fetched question, and most likely would be some kind of herb that nobody really researched yep, maybe in the future will become abundant and will work great. Esp for social phobia.
Im taking adderall, I seem to have alot of ability to work on my computer and read, than to go out and socialize. Esp after the primary effects wore off, I know the first week on 30mg of adderall, i was a chatter box, but that wore off, but my Add symptoms are alot better.
Im also taking Lexapro, to kick in some serotonin, and Klonopin at low doses.
Natural aminos, like DL-Phenylalanine is more of an endorphan like amino, but I dont notice such. L-Phenylanline is more NOrepinephrine Production. I do take 50mg of 5-Htp with 10mg of lexapro, figuring, both are low doses , as i do L-Tyrosine, which is a precursor to Dopamine, but again, cant feel any or much difference.Im going to post a new segment, about natural precursors and what I have experienced. After taking about 20 over the past 2 yrs, I may have some output on the subject.
MResearch
Posted by Mindreseacher on October 29, 2004, at 23:38:54
In reply to L-Deprenyl/Selegeline make Social Phobia worse?, posted by 3 Beer Effect on October 29, 2004, at 20:17:04
Hey 3 beers, its geno, how ya been. My god, I was looking for you about a month ago. I was telling people and another cat how you know your stuff about Psychostimulants.
The last posts i have printed from you , I was trying to get adderall. NOw i finally got adderall, then dexedrine spanuals, back to adderall. Im at 90mg of adderall, 3x daily, and my tolerance is like bad.
I even once or twice did 45mg 2x daily, not much difference. Iv tried alot of things to attempt to get the tolerance back, and cant seem to do it, except I ran out of adderall for 8 days, and what a horrible 8 days, but that day i resumed, I felt like superman. (well ok, batman )LOL Give me shout back
geno
Posted by Dr. Bob on October 30, 2004, at 2:06:45
In reply to Re: L-Deprenyl/Selegeline make Social Phobia worse?, posted by Mindreseacher on October 29, 2004, at 23:38:54
> its geno
Please don't post under more than one name at the same time.
If you or others have questions about this or about posting policies in general, please see the FAQ:
http://www.dr-bob.org/babble/faq.html#names
Follow-ups regarding these issues should be redirected to Psycho-Babble Administration.
Thanks,
Bob
Posted by Sad Panda on October 30, 2004, at 6:52:32
In reply to L-Deprenyl/Selegeline make Social Phobia worse?, posted by 3 Beer Effect on October 29, 2004, at 20:17:04
> I have been taking Eldepryl/L-Deprenyl/Selegeline for about 3 weeks now. It took about 10 days to start working, but now seems to be making social anxiety worse, in a manner similar to that caused by Ritalin where I have an excessive amount of self-consciousness.
>
> I was sure Selegeline would be the answer to cure Social Phobia because there is a dopaminergic theory of social phobia & because I used to take Dextrostat(d-amphetamine) or even street methamphetamine both of which helped greatly with social phobia. Why would amphetamines (which also release the bad norepinephrine in addition to dopamine) help with social phobia but selegeline (which exclusively increases dopamine) cause anxiety/social phobia?
>
> Also, I take DLPA 500 mg every morning. I was sure that DLPA, since it converts to PEA when you are taking Selegeline, would cause a glorious Dextrostat feeling but it mainly causes dysphoria, nervousness & slight paranoia. What gives?
>
> I am thinking of ditching the Selegeline & after a 2 week washout period, switching to a low dose of generic Prozac (10 mg) since SSRIs do seem to be the only drugs besides alcohol (the best) & amphetamines (2nd best) to have any real effects on sociability. But, when I was in college on Zoloft 100 mgs I almost failed myself out of school because SSRIs seem to diminish your short term memory (& after a few months I became manic) & since my job is intellectually demanding, taking a dumb drug could get me fired.
>
> 3 Beer Effect
>
>Increasing Dopamine alone is probably just as much doomed as raising Serotonin alone like SSRI's do. I would try increasing your Selegiline doseage until it becomes a non-selective MAOI like Parnate. Of course you will have to observe the normal MAOI diet & drug restrictions.
Cheers,
Paul.
Posted by linkadge on October 30, 2004, at 16:16:44
In reply to Re: L-Deprenyl/Selegeline make Social Phobia worse? » 3 Beer Effect, posted by Sad Panda on October 30, 2004, at 6:52:32
It was mentioned that the street drugs you took would have had an effect on serotonin release.
Deprenyl would have a powerful effect on dopamine/norepinephrine but would have little effect on serotonin (minimal MAO-A inhibition)
You could try adding a low dose of a serotogenic agent ie lexapro.Or have you tried nardil ??
Linkadge
Posted by utopizen on October 30, 2004, at 17:34:36
In reply to L-Deprenyl/Selegeline make Social Phobia worse?, posted by 3 Beer Effect on October 29, 2004, at 20:17:04
Rarely does any psychotropic, except the amphetamines, cause anxiety forever. Anxiety often is a sign it's "working" on your anxiety, and it tends to go away after a few weeks when your body is adjusted to the med.
And don't think you need to worry about taking a stimulant to be more sociable. Social anxiety disorder is about being too anxious, not being too introspective. If you think you need to talk more to others by taking a drug, you should probably realize that few people like to be friends with others who talk a lot. I don't talk much at all-- I listen. And I make a lot of good friends that way. If you talk a lot, people tend to avoid you/dislike you. I never am friends to people who talk a lot.
Posted by jparsell82 on October 30, 2004, at 21:37:28
In reply to L-Deprenyl/Selegeline make Social Phobia worse?, posted by 3 Beer Effect on October 29, 2004, at 20:17:04
I had a similar bad experience on Deprenyl for social phobia. I was taking 5-10mg a day with DLPA for about 1-2 months. It slowly kept increasing my anxiety to horrible levels, it made me dysphoric, agitated, etc. I do not recommend it for social phobia. However, I did notice positive results when I tried Adderall in regards to sociability.
Posted by sfy on October 31, 2004, at 17:18:35
In reply to Re: L-Deprenyl/Selegeline make Social Phobia worse?, posted by jparsell82 on October 30, 2004, at 21:37:28
Selegiline (5-10 mg. per day plus DLPA) had no effect, for better or worse, on my social phobia, or on my dysthymia for that matter.
This is the end of the thread.
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