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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by iris2 on October 31, 2004, at 16:36:21
I saw the following statement and wondered if there was a way around this:
"My theory is that, because it's an agonist, the brain down-regulates the dopamine receptors to compensate, so eventually the benefit wears off."
irene
Posted by linkadge on October 31, 2004, at 16:44:07
In reply to Mirapex-down-regulate dopamine?, posted by iris2 on October 31, 2004, at 16:36:21
The downregulation does not mean it wears off. Infact the alteration in receptors can occur when the drug works.
For instance. SSRI's downregulate the 5-ht1a receptors, but this is one of the things that is believed to be associated with the responce. Ie post mortem brains have shown to have significantly upregulated 5-ht1a receptors.
Linkadge
Posted by iris2 on October 31, 2004, at 18:41:53
In reply to Re: Mirapex-down-regulate dopamine?, posted by linkadge on October 31, 2004, at 16:44:07
Posted by denise1904 on November 19, 2004, at 10:55:42
In reply to Re: Mirapex-down-regulate dopamine?, posted by linkadge on October 31, 2004, at 16:44:07
Linkadge,
Hope you are feeling better. How do they know that SSRIs down regulate 5-ht1a can they actually see that happening with scans? Also why would reducing the number of 5-ht1a receptors have an affect on depression?
I always seem to be on here to ask questions but it's only because there are so many people on here who seem so much more knowledgeable on this subject. I never even did chemistry at school and so feel way out of my depth sometimes.
Denise
This is the end of the thread.
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