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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by iris2 on October 22, 2004, at 12:54:08
Have read several posts mentioning this with Cymbalta. I am thinking about taking it but I have a bladder disease and if people are routinely getting hesitation it would be not so prudent for me to take this as my first choise. Appreciate a response from people who have had it or take it and have no problem.
Irene
Posted by RetiredYoung on October 22, 2004, at 13:55:05
In reply to Cymbalta-Need infor -Urinary Hesitation, posted by iris2 on October 22, 2004, at 12:54:08
Sorry to sound silly, but what exactly is "urinary hesitation"? I'm on a tricyclic AD and have to urinate much more frequently - is that the same thing? Thanks.
Jim
Posted by iris2 on October 22, 2004, at 14:12:21
In reply to Re: Cymbalta-Need infor -Urinary Hesitation » iris2, posted by RetiredYoung on October 22, 2004, at 13:55:05
It is not the same thing. Generally it meens it is hesitant, just like the word meens. It is difficult to go, one might have to push more. I would think for some if one has hesitation you might tend to have to go more but not necessarily. You might just be more thirsty on the tricyclic so if you drink more you might have to go more that would be the frequency at which you go. Unless it is interfering with your functioning or sleep do not worry. If you think it is something besides the medicine and the fact that you are a man I might have it checked, but do not worry.
irene
Posted by Kristel on October 22, 2004, at 15:45:11
In reply to Re: Cymbalta-Need infor -Urinary Hesitation » iris2, posted by RetiredYoung on October 22, 2004, at 13:55:05
Yes. Despite that to urinate frequently and urinary hesitation are not the same, their underlying physiological cause might be the same. Such side effects of the drugs that affect noradrenaline are casued by noradrenaline over stimulating the alpha 1 adrenergic receptors in the prostate. This can tighten it up and enlarge it a bit. This in turn can cause to either hesitation or frequent urination or both.
Kristel.
Posted by King Vultan on October 22, 2004, at 17:18:45
In reply to Re: Cymbalta-Need infor -Urinary Hesitation, posted by Kristel on October 22, 2004, at 15:45:11
> Yes. Despite that to urinate frequently and urinary hesitation are not the same, their underlying physiological cause might be the same. Such side effects of the drugs that affect noradrenaline are casued by noradrenaline over stimulating the alpha 1 adrenergic receptors in the prostate. This can tighten it up and enlarge it a bit. This in turn can cause to either hesitation or frequent urination or both.
>
> Kristel.Right. In some cases, the stimulation of the alpha-1 receptors can cause the muscles of the prostate to constrict and limit urinary flow. Thus, a fellow might not be able to empty his bladder other than a small amount that is basically forced out from the pressure inside the bladder, aided by whatever force he can exert. The bladder is still mostly full--or at least not completely empty, depending on how severe the problem is--so it then refills more quickly than normal, forcing the man to go again, and this cycle repeats itself. An alpha-1 blocker, such as doxazosin, prazosin, or terazosin, can be an aid in these situations.
Todd
Posted by RetiredYoung on October 22, 2004, at 19:11:51
In reply to Re: Cymbalta-Need infor -Urinary Hesitation, posted by King Vultan on October 22, 2004, at 17:18:45
All - Thanks for the very interesting info on this.
Jim
Posted by iris2 on October 22, 2004, at 20:35:56
In reply to Re: Cymbalta-Need infor -Urinary Hesitation, posted by King Vultan on October 22, 2004, at 17:18:45
Would this work to help me in a womans case do you think? My problem is from this disease but perhaps it is a stronger effect from the same thing you are talking about. Drugs like amineptine, effexor, amisulpride some, most stimulants,flexeril are a few examples of meds tht I cannot take due to bladder problems.
irene
Posted by King Vultan on October 22, 2004, at 23:31:38
In reply to Re: Cymbalta-Need infor -Urinary Hesitation » King Vultan, posted by iris2 on October 22, 2004, at 20:35:56
> Would this work to help me in a womans case do you think? My problem is from this disease but perhaps it is a stronger effect from the same thing you are talking about. Drugs like amineptine, effexor, amisulpride some, most stimulants,flexeril are a few examples of meds tht I cannot take due to bladder problems.
>
> irene
In my opinion, yes, an alpha blocker might help you be able to take some of these drugs, but I am not a female, nor am I a urologist. Actually, the one urologist I have seen did happen to be a female, and we got into an argument about alpha-1 receptors in the bladder neck. If you do any kind of research on the topic, it becomes readily apparent that this is the kind of receptor in the area of the bladder neck, but she asserted otherwise. I did get a prescription for an alpha blocker because she at least knew that alpha-1 receptors are the important ones in the prostate (particularly the 1a receptors). The thing with these drugs is that they are mainly prescribed for men with enlarged prostates, and I don't know if doctors and urologists in general have figured out that they do have utility in other situations. In my case, my prostate is normal size and not enlarged; my alpha-1 receptors are simply hypersensitive.Todd
Posted by Cecilia on October 23, 2004, at 3:12:12
In reply to Cymbalta-Need infor -Urinary Hesitation, posted by iris2 on October 22, 2004, at 12:54:08
Considering that Cymbalta is also being marketed for urinary incontinence you`d think this would be a very common side effect, but no one seems to be complaining about it much. Makes you wonder how well it could work for incontinence. I`ve had lots of side effects with Cymbalta, but no bladder problems. Cecilia
Posted by King Vultan on October 23, 2004, at 10:07:25
In reply to Re: Cymbalta-Need infor -Urinary Hesitation, posted by Cecilia on October 23, 2004, at 3:12:12
> Considering that Cymbalta is also being marketed for urinary incontinence you`d think this would be a very common side effect, but no one seems to be complaining about it much. Makes you wonder how well it could work for incontinence. I`ve had lots of side effects with Cymbalta, but no bladder problems. Cecilia
In my research last year, I learned that imipramine is the traditional drug used for female incontinence. The particular blend of anticholinergic, alpha adrenergic, antihistaminic, and NE reuptake blockades that imipramine posseses seems to have the most favorable overall effects on female urinary function that is being compromised by incontinence. I think all Cymbalta has going it for it in this area is its blockade of NE reuptake--I'm sure it has some efficacy, but you would think there are cheaper drugs available that would do the same thing. Perhaps Cymbalta has an advantage in its side effect profile, though.Todd
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