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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by ftlmatt on October 2, 2004, at 14:23:02
i have been on dexedrine for over a year now for my ADD..my doc added wellbutrin sr. a month ago for my depression...
after taking the wellbutrin i have noticed that the stimulant effects of the dexedrine have been reduced. is this due to the wellbutrin?
i have heard that wellbutrin could enhance the effects of a stimulant but not reduce it!!!
Posted by bart on October 3, 2004, at 7:58:12
In reply to wellbutrin and dexedrine, posted by ftlmatt on October 2, 2004, at 14:23:02
I would have thought the same thing too! maybe the sertonin effects of the wellbutrin are calming your emotional responses.
Posted by ftlmatt on October 3, 2004, at 11:44:33
In reply to Re: wellbutrin and dexedrine, posted by bart on October 3, 2004, at 7:58:12
> I would have thought the same thing too! maybe the sertonin effects of the wellbutrin are calming your emotional responses.
from what i have read, wellbutrin does not affect serotonin at all...i have not experienced any of the "stimulant" side effects from the wellbutrin either
Posted by Optimist on October 3, 2004, at 12:00:23
In reply to wellbutrin and dexedrine, posted by ftlmatt on October 2, 2004, at 14:23:02
I would think that wellbutrin would increase the effectiveness of the dexedrine as well since wellbutrin is a norepinephrine and dopamine reuptake inhibitor. Since dexedrine is mainly a norepinephine releaser I believe, you would think that the effect would be intensified.
Another thing to note though. Wellbutrin is typically used to treat drug addiction, namely for smoking I know. It's possible that the wellbutrin is reducing the reinforcement properties of the dexedrine and thus you're not feeling this effect anymore. It's possible that the dexedrine is still working on some other level though.
Posted by bart on October 3, 2004, at 14:59:55
In reply to Re: wellbutrin and dexedrine, posted by ftlmatt on October 3, 2004, at 11:44:33
last time I looked at any clinical pharmacology of wellbutrin it was shown to have a higher affinity for serotonin and norepinephrine and only a little bit for dopamine. But I've heard so many mixed things you know
Posted by Optimist on October 4, 2004, at 15:15:12
In reply to Re: wellbutrin and dexedrine, posted by bart on October 3, 2004, at 14:59:55
> last time I looked at any clinical pharmacology of wellbutrin it was shown to have a higher affinity for serotonin and norepinephrine and only a little bit for dopamine. But I've heard so many mixed things you know
I've heard about that too. I guess it's not totally known how Wellbutrin works yet. It's mostly theories at this point.
Posted by pablo1 on October 4, 2004, at 20:09:44
In reply to Re: wellbutrin and dexedrine, posted by bart on October 3, 2004, at 14:59:55
> last time I looked at any clinical pharmacology of wellbutrin it was shown to have a higher affinity for serotonin and norepinephrine and only a little bit for dopamine. But I've heard so many mixed things you know
My understanding is wellbutrin does nothing for seratonin, mostly norepenephrine & a bit on dopamine. I ran across the following chart though which is very contradictory & perhaps misunderstood. The comments below are from other posters asking questions:
Here is a table with the relative values of blockade of NA, 5HT and DA
the greater the value,
the greater the affinity for blocking the re-uptake site.5HT NA DA
Zoloft sertraline 0.2400 341.0000 0.3800
Ritalin
4.0000Seroxat paroxetine 2.5000 798.0000 0.2000
Wellbutrin buproprion 0.0019 0.0110 0.1900
Effexor venlafaxine 0.0940 11.0000 0.0110
Lexapro citalopram 2.7000 86.0000 0.0036
Deproxin fluoxetine 0.4100 123.0000 0.0280
Edronax, Vestra reboxetine 14.0000 1.7000 0.0087
Where did you get these numbers?
The potency stats I have are from A Primer of Drug Action by Robert M.
Julien, M.D., Ph.D.These numbers do not make any sense to me. (First off, did I get the
right numbers under the right neurotransmitters, the table was a little
messed up on my newsreader??) Second, I assume these neurotransmitter
columns and the values under them are ment to represent inhibition of
reuptake of that neurotransmitter (and not inhibition of one of the many
receptor subtypes for each type of receptor). But what really has me
confused is what the values represent numerically. They are presumably
IC50 values (a measure of drug affinity) given in maybe micromolar
concentrations?? If they are, then the lower the numerical value the
greater affinity the drug has for blocking the reuptake of that
neurotransmitter. Sometimes IC50 values are given in -log units, and when
that happens the larger the number the higher the affinity. But that
doesn't seem to be the case here. I am confused.
This is the end of the thread.
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