![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 20 to 44 of 44. Go back in thread:
Posted by SLS on June 3, 2000, at 9:37:20
In reply to Re: Amisulpride, Peter S, posted by AndrewB on June 3, 2000, at 8:46:29
Dear Fellow Sufferers,
I am confused here.Who is currently taking Nardil + amisulpride in combination?
Is there a trend towards amisulpride producing sleepiness or sedation when it is added to Nardil?
Is anyone combining amisulpride with Parnate?
Thanks.
- Scott
------------------------------------
> Peter,
>
> Your diagnosis of dysthymia and social phobia indicates dopaminergic D2-3 hypofunction. A recent study indicated low D2 receptor binding potentials in social phobia. Nardil has long thought to be effective for social phobia due to its dopaminergic action. Therefore one would think that the D2-3 dapaminergic activity enhancing amisulpride would be a drug that you would be responsive to. But this obviously wasn't the case. All you experienced was sleepiness. Michael experienced the same thing at 50mg. Sleepiness indicates that one is taking too much amisulpride and the postsynaptic, rather than the targeted presynaptic D2-3 receptors, are being stimulated. Intuitively the solution would be to lower the dose. Michael has done this, lowered his dose to 12.5 mgs., with some initially promising results. You may therfore wish to retry amisulpride at a lower dose (such as 25mgs) as an augmenting agent to nardil. Let me know if you find this effective. Indeed, if you are able to find effective dopaminergic augmenting agents for Nardil (like amisulpride), you should be able to lower the effective dose of nardil and thus lower your side effects.
Posted by Seamus2 on June 3, 2000, at 9:56:42
In reply to Who is taking Amisulpride + Nardil or Parnate ? » AndrewB, posted by SLS on June 3, 2000, at 9:37:20
Scott,
I'll be giving the Parnate a two week washout, then trying the amisulpride. It gets but a two week shot itself, then I'll add the Parnate again.
Will let you know.
Seamus
> Dear Fellow Sufferers,
>
>
> I am confused here.
>
> Who is currently taking Nardil + amisulpride in combination?
>
> Is there a trend towards amisulpride producing sleepiness or sedation when it is added to Nardil?
>
> Is anyone combining amisulpride with Parnate?
>
> Thanks.
>
>
> - Scott
>
Posted by Peter S. on June 3, 2000, at 12:06:56
In reply to Re: Amisulpride, Peter S, posted by AndrewB on June 3, 2000, at 8:46:29
Andrew:
Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
Peter
> Peter,
>
> Your diagnosis of dysthymia and social phobia indicates dopaminergic D2-3 hypofunction. A recent study indicated low D2 receptor binding potentials in social phobia. Nardil has long thought to be effective for social phobia due to its dopaminergic action. Therefore one would think that the D2-3 dapaminergic activity enhancing amisulpride would be a drug that you would be responsive to. But this obviously wasn't the case. All you experienced was sleepiness. Michael experienced the same thing at 50mg. Sleepiness indicates that one is taking too much amisulpride and the postsynaptic, rather than the targeted presynaptic D2-3 receptors, are being stimulated. Intuitively the solution would be to lower the dose. Michael has done this, lowered his dose to 12.5 mgs., with some initially promising results. You may therfore wish to retry amisulpride at a lower dose (such as 25mgs) as an augmenting agent to nardil. Let me know if you find this effective. Indeed, if you are able to find effective dopaminergic augmenting agents for Nardil (like amisulpride), you should be able to lower the effective dose of nardil and thus lower your side effects.
Posted by AndrewB on June 5, 2000, at 18:31:55
In reply to Re: Amisulpride, Andrew, posted by Peter S. on June 3, 2000, at 12:06:56
> Andrew:
>
> Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
>
Peter,Can amisulpride be combined with an MAOI? That is an important question. I think I can get an answer but give me some time. Keep checking back.
AndrewB
Posted by michael on June 5, 2000, at 18:54:06
In reply to Re: Amisulpride, Andrew, posted by AndrewB on June 5, 2000, at 18:31:55
This is not entirely, but at least in part, the same question as amisulpride & selegiline thread was addressing. As I think I mentioned, I was wondering about that combo specifically, because both of these meds target the dopamine system.
I was referring to only 10mg selegiline daily, which, at this low dosage, preferentially inhibits MAOI-B. (MAOI-B the one that is supposed to break down dopamine). I've decided to give it a try, however, I am also taking a lower than usual dose of amisulpride - only approx. 12.5mg per day - just a quarter of a 50mg tablet (due to the fact that 50mg/day had me sleeping at least 12 hours/day).
Btw, tried going up to 25mg amisulpride/day, and was tired and lethargic & apathetic... not good. Don't know if that would've been the case w/o the selegiline. I had been taking the selegiline for about 10 - 14 days at the time, and the amisulpride for about 4 - 8 days when I tried the 25mg dose. Sorry, I guess I should've been making notes...
I don't have anything to contribute about other maoi's...
> > Andrew:
> >
> > Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
> >
> Peter,
>
> Can amisulpride be combined with an MAOI? That is an important question. I think I can get an answer but give me some time. Keep checking back.
>
> AndrewB
Posted by AndrewB on June 5, 2000, at 23:47:44
In reply to Re: Amisulpride MAOI, posted by michael on June 5, 2000, at 18:54:06
Thanks for the new info. on your amisulpride experience.Recently read a study abstract that indicates 5mg. of selegiline does the same as 10mg.
Have you noticed any improvement on your seligiline, amisulpride combo.
I've had nice results with entacapone as a dopaminergic agent of arousal. I want to wait until I get a chance to combine it with Sinemet before I say anything more about it though.
AndrewB
Posted by SLS on June 6, 2000, at 7:54:58
In reply to Re: Amisulpride, Selegiline- Michael, posted by AndrewB on June 5, 2000, at 23:47:44
> I've had nice results with entacapone as a dopaminergic agent of arousal. I want to wait until I get a chance to combine it with Sinemet before I say anything more about it though.
This is very encouraging, Andrew. How would you describe "arousal"? What dosage are you currently taking, and what is the highest dosage you would consider trying?
- Scott
Posted by michael on June 6, 2000, at 10:15:39
In reply to Re: Amisulpride, Selegiline- Michael, posted by AndrewB on June 5, 2000, at 23:47:44
I can't say that I've noticed much of a difference - but as I mentioned, I started the selegiline pretty quickly after the amisulpride... too close to differentiate?
I'm thinking of trying stopping the amisulpride some time for a week or two, to try to better determine specifically what difference it makes...
Btw, I was kind of surprised by JohnL's comments on the negative sexual effects of the amisulpride. One of the reasons I wanted to try it again at the low dose, was that selegiline supposedly had positive effects in that arena - my thinking being that low doses of each med works to increase the dopamine...? And I don't have any problems w/that at the moment...?
> Thanks for the new info. on your amisulpride experience.
>
> Recently read a study abstract that indicates 5mg. of selegiline does the same as 10mg.
>
> Have you noticed any improvement on your seligiline, amisulpride combo.
>
> I've had nice results with entacapone as a dopaminergic agent of arousal. I want to wait until I get a chance to combine it with Sinemet before I say anything more about it though.
>
> AndrewB
Posted by Ant-Rock on June 6, 2000, at 10:47:10
In reply to Re: Amisulpride, Andrew, posted by AndrewB on June 5, 2000, at 18:31:55
> > Andrew:
> >
> > Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
> >
> Peter,
>
> Can amisulpride be combined with an MAOI? That is an important question. I think I can get an answer but give me some time. Keep checking back.
>
> AndrewB
Hello everyone,
I am currently taking 40mg Parnate, 25mg Amisulpride, and between 20-30mg Ritalin/day. I just added the amisulpride to the mix yesterday in hopes of giving me back some sex drive. My first trial of amisulpride @50mg and eventually 100mg didn't have any effect, but this was done without the Parnate. If there are any surprises(good or bad)with this combo I will let you know.Best wishes to all,
Anthony
Posted by SLS on June 6, 2000, at 14:52:55
In reply to Re: Amisulpride, Andrew and all, posted by Ant-Rock on June 6, 2000, at 10:47:10
> Hello everyone,
> I am currently taking 40mg Parnate, 25mg Amisulpride, and between 20-30mg Ritalin/day. I just added the amisulpride to the mix yesterday in hopes of giving me back some sex drive. My first trial of amisulpride @50mg and eventually 100mg didn't have any effect, but this was done without the Parnate. If there are any surprises(good or bad)with this combo I will let you know.
>
> Best wishes to all,
> Anthony
Anthony - Thank you very much for this post. Parnate + amisulpride is one of the combinations I asked my doctor to look into. Now I can tell him that I have a guinea pig.GOOD LUCK !!!
By the way, why are you taking Ritalin, and how have you benefited from it?
Is your lack of sex-drive simply a feature of depression, or is it being caused by medication? Does Parnate + Ritalin completely take care of your depression?
Are you bipolar? How would you describe your depressed state? Which drugs have you benefited from in the past.
Sorry about all of the questions.
Thanks again.
- Scott
Posted by Ant-Rock on June 6, 2000, at 17:57:56
In reply to Re: Amisulpride, Andrew and all » Ant-Rock, posted by SLS on June 6, 2000, at 14:52:55
> > Hello everyone,
> > I am currently taking 40mg Parnate, 25mg Amisulpride, and between 20-30mg Ritalin/day. I just added the amisulpride to the mix yesterday in hopes of giving me back some sex drive. My first trial of amisulpride @50mg and eventually 100mg didn't have any effect, but this was done without the Parnate. If there are any surprises(good or bad)with this combo I will let you know.
> >
> > Best wishes to all,
> > Anthony
>
>
> Anthony - Thank you very much for this post. Parnate + amisulpride is one of the combinations I asked my doctor to look into. Now I can tell him that I have a guinea pig.
>
> GOOD LUCK !!!
>
> By the way, why are you taking Ritalin, and how have you benefited from it?
>
> Is your lack of sex-drive simply a feature of depression, or is it being caused by medication? Does Parnate + Ritalin completely take care of your depression?
>
> Are you bipolar? How would you describe your depressed state? Which drugs have you benefited from in the past.
>
> Sorry about all of the questions.
>
> Thanks again.
>
>
> - Scott
No Scott, I am not bipolar. My loss of libido has been with me ever since I had a severe traumatic reaction to a drug called Amoxapine. This med I was trying while being treated for a dysthymic depression/fatigue, sent my mind and body into a severe tailspin. I could go on describing all the problems this reaction left me with such as weakness and severe anhedonia, but it's just to sad to think about for very long. I've tried to get answers(God knows)but I've come up empty time and again.
I'm taking ritalin to augment the parnate, after reading about many successes this combo has had for extremely treatment resistant patients. I've read about grand remissions from this combo in DR. Bobs tips section(keywords: stimulants,maois)that several Doctors spoke of.
I've been on parnate before with decent results, hoping to increase dosage from 40mg soon. So far this combo hasn't been spectacular, but I'm still on a relatively low dose parnate, but it's at least given me the energy to get up and function in the morning. 2 weeks ago I was pretty much a vegetable, so I guess I should be thankful. Unfortunately the anhedonia is still prevalent.
Drugs that helped me in the past?
-Parnate somewhat
-Amineptine in some ways
-rTMS(transcr.magnetic-stim),subtle,very transient
-Ritalin after about my first week(only 10mg/day) I noticed much improved mood and anhedonia started to lift, I actually wanted to do things, but these short lived improvements began to wane and even upon increasing the dose it hasn't returned.
The components of my depression have always been the atypical kind. Slowed mental & physical fuction, fatigue, tiredness, lack of sex drive, apathy and so on. I've never had severe anxieties,panic, or mania.
Hope I could be of some help Scott, feel free to comment or ask anything, I certainly don't mind the questions and I always appreciate the input I get hear as well.
Anthony
Posted by michael on June 6, 2000, at 20:21:00
In reply to Re: Amisulpride, Selegiline- Michael, posted by AndrewB on June 5, 2000, at 23:47:44
Hey Andrew -
I did a bit or reading on the meds you mentioned... I had been wondering about levodopa as a possibility. Sounds interesting, if dopamine's the issue... Good Luck! I'll be looking forward to your "report".
The only other thing I would say is to be careful... Too much of a good thing (dopamine, in this case) might not be a good thing.
Isn't that (too much dopamine) what neuroleptics - like higher-dose amisulpride, etc. - are trying to address? Might psychotic symptoms be a side effect if carried beyond a certain point?
I've been wondering about that myself, since I've been experimenting w/low-dose amisulpride and selegiline...
One last Q for you... have you come across much/any rsch that specifically looks at dopamine (and its manipulation) as a focus in the treatment of depression/dysthymia? I haven't looked as of yet... Serotonin seems to get the lion's share of media attention... just curious. michael
> Thanks for the new info. on your amisulpride experience.
>
> Recently read a study abstract that indicates 5mg. of selegiline does the same as 10mg.
>
> Have you noticed any improvement on your seligiline, amisulpride combo.
>
> I've had nice results with entacapone as a dopaminergic agent of arousal. I want to wait until I get a chance to combine it with Sinemet before I say anything more about it though.
>
> AndrewB
Posted by SLS on June 7, 2000, at 8:02:04
In reply to Re: Amisulpride, Selegiline- Michael » AndrewB, posted by michael on June 6, 2000, at 20:21:00
> The only other thing I would say is to be careful... Too much of a good thing (dopamine, in this case) might not be a good thing.
>
> Isn't that (too much dopamine) what neuroleptics - like higher-dose amisulpride, etc. - are trying to address? Might psychotic symptoms be a side effect if carried beyond a certain point?Yes. L-dopa by itself occasionally produces psychosis when used to treat Parkinson's Disease. Such a reaction is usually treated with a neuroleptic at appropriate dosages.
> > Recently read a study abstract that indicates 5mg. of selegiline does the same as 10mg.
Trial and error is still, of course, often a necessity when dealing with the human body.
- Scott
Posted by SLS on June 7, 2000, at 8:23:40
In reply to Re: Amisulpride, Andrew and all, posted by Ant-Rock on June 6, 2000, at 17:57:56
> No Scott, I am not bipolar. My loss of libido has been with me ever since I had a severe traumatic reaction to a drug called Amoxapine.
> This med I was trying while being treated for a dysthymic depression/fatigue, sent my mind and body into a severe tailspin. I could go on describing all the problems this reaction left me with such as weakness and severe anhedonia, but it's just to sad to think about for very long.
Yes. I experienced a similar reaction to this drug. I recently made a stealthy reference to this drug in a previous post. Your reaction to amoxapine may have been due, in part, to its abiity to block dopamine receptors with signigicant potency. I believe that the symptoms that appeared or that were aggravated are an indicator that your pursuit of dopaminergic drugs is a good idea. Just don't exclude all others. The brain defies explanation.
> I've tried to get answers(God knows)but I've come up empty time and again.
Well, at least now you have an answer to the human components of your experience.
> I'm taking ritalin to augment the parnate, after reading about many successes this combo has had for extremely treatment resistant patients. I've read about grand remissions from this combo in DR. Bobs tips section(keywords: stimulants,maois)that several Doctors spoke of.
Yes.
- High-dose Parnate 100mg - 150mg
- add tricyclics (desipramine)
- add amphetamine
- add ritalin
- add Parlodel, Permax, Mirapex - DA receptor agonists
- add lithium - low dose - 300 - 600mg
- add Wellbutrin- Mix and match
> I've been on parnate before with decent results, hoping to increase dosage from 40mg soon. So far this combo hasn't been spectacular, but I'm still on a relatively low dose parnate, but it's at least given me the energy to get up and function in the morning. 2 weeks ago I was pretty much a vegetable, so I guess I should be thankful. Unfortunately the anhedonia is still prevalent.
> Drugs that helped me in the past?
> -Parnate somewhat
> -Amineptine in some ways> -rTMS(transcr.magnetic-stim),subtle,very transient
Where did you receive these treatments? S.C.? Was it part of a research investigation? Who was the primary investigator?
> -Ritalin after about my first week(only 10mg/day) I noticed much improved mood and anhedonia started to lift, I actually wanted to do things, but these short lived improvements began to wane and even upon increasing the dose it hasn't returned.
You and I are similar in this respect.
> The components of my depression have always been the atypical kind. Slowed mental & physical fuction, fatigue, tiredness, lack of sex drive, apathy and so on.
These are also my primary symptoms.
> I've never had severe anxieties,panic, or mania.
How old are you?
I am not sure as to the role mood stabilizers are currently viewed to have in atypical unipolar depression, but you may want to look into it. I know that they are used sometimes. I mentioned low-dose lithium. This is *definitely* used with great success, especially when added to Parnate. Check out Lamictal.
> Hope I could be of some help Scott, feel free to comment or ask anything, I certainly don't mind the questions and I always appreciate the input I get hear as well.
> AnthonyYou have. I hope I have done the same for you. I'll post anything I come up with. Thanks for your reply.
Sincerely,
Scott
Posted by Ant-Rock on June 7, 2000, at 18:44:30
In reply to Re: Amisulpride, Andrew and all » Ant-Rock, posted by SLS on June 7, 2000, at 8:23:40
> Where did you receive these treatments? S.C.? Was it part of a research investigation? Who was the primary investigator?
Beth Isreal Medical Center, Boston,MA
Headed by Dr. Pascual-Leone, and it was a research investigation. My trial ended last fall.
> How old are you?
32, Residing in Providence, RI
> I am not sure as to the role mood stabilizers are currently viewed to have in atypical unipolar depression, but you may want to look into it. I know that they are used sometimes. I mentioned low-dose lithium. This is *definitely* used with great success, especially when added to Parnate. Check out Lamictal.Actually Scott, my p-doc wants to try Depakote next as an augmentor, He was negative towards the Lithium because of possible kidney damage, which he has recently been seeing in some patients.
Scott,
Thank you for the great info on all the Parnate augmenting drugs, I didn't realize tricyclics or welbutrin were being used for this.
I just came across a scrap paper I had copied something down from a while back, the web address is (www.appi.org),and a quote from a Dr.says "The major problem reccomending stimulants is underdosage(e.g.5-10mg methylphenidate 1 or 2x day)" "In the absence of any effect, pos or negative, the dosage should be steadily increased up to 40mg/day of D-amphet, 80mg/day of methylphenidate, or 300 mg/day pemoline."
Just thought it was interesting and figured I'd pass it on to you.Take Care,
Anthony
Posted by AndrewB on June 7, 2000, at 20:19:54
In reply to Re: Amisulpride, Andrew and all » SLS, posted by Ant-Rock on June 7, 2000, at 18:44:30
Can an MAOI (Parnate, Nardil) be combined with amisulpride?
I got a response from a psychiatrist who used amisulpride extensively in Columbia. She related that she never used amisulpride in combination with other medications She said that, in her opinion, amisulpride should never be combined with an MAOI. I hope that Anthony and Seamus work closely with their psychiatrists when trying such a combination since this is new territory.
Various dopamine enhancers can induce psychotic symptoms in certain individuals. Though this doesn't seem to be an issue with me, people should be on the look out for this side effect when using dopamine enhancers. Another indication of too much dopamine is decreased mental focus. Dopamine has a bell curve effect on attentiveness, improving it up to a point and thereafter making the mind flighty and less able to focus on things.
As far as research goes concerning the connection between dopamine and depression I can suggest an article entitled 'The role of stress in the pathophysiology of the dopaminergic system' as a good place to start to get an understanding of how dopamine system dysregulation can evolve. To view this article go to www.stockton-press.co.ul/server-java/Propub/stockton/spmp v5 n1 p14 o1.fulltext (note that the spaces on this address should be underline marks> I don't seem to be able to type those marks into this message form.) There are many more articles written on this subject but unfortunately they are not up on the net. You can however search medline abstracts and get an idea of what's out there.
Best wishes,
AndrewB
Posted by Ant-Rock on June 8, 2000, at 17:51:07
In reply to Re: Amisulpride, to all, posted by AndrewB on June 7, 2000, at 20:19:54
Thank you for that info Andrew, actually it's the Ritalin augmentor that I have to keep cutting down, due to feeling kind of out of it, and not being able to concentrate, maybe this is due to the "to much dopamine" effect you spoke of. I've cut down the Ritalin to almost nothing, and that has seemed to help. I also seem to feel much better lately in the AM hours, which is also when I take the 25mg amisulpride, but perhaps this is coincidence.
I hope things are well with you Andrew,
Please take care,
Anthony
Posted by DC on June 9, 2000, at 0:09:21
In reply to Re: Amisulpride, to all » AndrewB, posted by Ant-Rock on June 8, 2000, at 17:51:07
I'm currently taking a combo of Neurontin for social phobia and Adderal for the inattentive subtype of ADD. I've been doing pretty good on this combo but would like to do better.
Several weeks ago I ordered Amisulpride and Adrafinil online. I tried the adrafinal alone for a few days but quit because without the adderal I was gaining weight. The amisulpride is supposed to get here in a few days. I'm hesitant to stop the Adderal because I enjoy being thin again. (Note: I was on Nardil and had gained thirty pounds). I'm hesitant to combine the adderal with either the amisulpride or adrafinil since they all affect dopamine. Any suggestions?
Thanks,
Dwight
Posted by Seamus2 on June 9, 2000, at 2:36:44
In reply to Re: Amisulpride, to all » AndrewB, posted by Ant-Rock on June 8, 2000, at 17:51:07
> maybe this is due to the "to much dopamine" effect you spoke of. I've cut down the Ritalin to almost nothing, and that has seemed to help. Anthony>Dopamine has a bell curve effect on attentiveness, improving it up to a point and thereafter making the mind flighty and less able to focus on things.
<<Cocaine in small amounts, w/ my usual Parnate dosage 10 mg TID, had the same effect: stimulation at lower doses and utter distraction at higher doses. I knew the risk, so spare the warnings (it was 6 years ago, anyway).
I recently (4 days) quit my morning cups (2) of coffee and am wondering if that's why I seem to be more even-tempered. Anyone w/ a caffeine taper story they'd lke to share?
As an aside, I'm waiting for for my shrink and I to get together and decide on an Amisulpride protocol. I tried washing out on the Parnate, but after a couple weeks decreasing to 20 mg/day I was in deep doo-doo and went back to 30 mg/day and I'm almost "normal."
I find it highly ironic and amusing that my worldview is so impacted by a mere ten milligrams of some damn chemical, but that's the way it is and has been for at least a decade.
Seamus
Posted by AndrewB on June 9, 2000, at 11:34:56
In reply to Re: Amisulpride, to all, posted by Seamus2 on June 9, 2000, at 2:36:44
Seamus,If I have coffee nowadays, I get angry/irritable few hours afterwords. I call it my coffee crash! Coffee doesn't seem to mix with the other chemicals I'm putting into my head.
It sounds good that you are consulting with your pdoc on the an amisulpride/parnate protocol. May I suggest that you closely track Anthony's reaction to the amisulpride/parnate/ritalin combo he is taking. He is your test subject.
Another option to amisulpride is Mirapex. It may work when amisulpride doesn’t. I am going to soon put together an information piece on Mirapex as I have for amisulpride. I also plan to put together an information piece that gives evidence supporting the use of D2-D3 receptor stimulators such as amisulpride and mirapex for social anxiety.
Also I will try to translate from Italian information on the pharmological properties of low dose amisulpride. If I am able to do this, I will post the translation here. Your pdoc may want to look at it to determine if there is any potential reaction to beware of.
Best wishes,
AndrewB
Posted by michael on June 9, 2000, at 12:36:43
In reply to Re: Amisulpride, to Seamus, posted by AndrewB on June 9, 2000, at 11:34:56
Hey Andrew -
I speak Italian, and don't find too much useful info on the package insert... although it does say that it is for short to medium term treatment of dysthymia.
All my insert says regarding dose is one tablet per day, or as prescribed by the doctor - and the other standard stuff you see in all of the English stuff we've read (e.g. dose may need to be reduced in elderly patients)
I don't see anything you wouldn't find at the amisulpride/solian web site (generally speaking - a LOT less than you'll learn/find at the web site) : http://solian.com.ph/
Ciao. michael
>
> Seamus,
>
> If I have coffee nowadays, I get angry/irritable few hours afterwords. I call it my coffee crash! Coffee doesn't seem to mix with the other chemicals I'm putting into my head.
>
> It sounds good that you are consulting with your pdoc on the an amisulpride/parnate protocol. May I suggest that you closely track Anthony's reaction to the amisulpride/parnate/ritalin combo he is taking. He is your test subject.
>
> Another option to amisulpride is Mirapex. It may work when amisulpride doesn’t. I am going to soon put together an information piece on Mirapex as I have for amisulpride. I also plan to put together an information piece that gives evidence supporting the use of D2-D3 receptor stimulators such as amisulpride and mirapex for social anxiety.
>
> Also I will try to translate from Italian information on the pharmological properties of low dose amisulpride. If I am able to do this, I will post the translation here. Your pdoc may want to look at it to determine if there is any potential reaction to beware of.
>
> Best wishes,
>
> AndrewB
Posted by S.D. on June 12, 2000, at 4:34:49
In reply to Re: Amisulpride, to all, posted by Seamus2 on June 9, 2000, at 2:36:44
> I recently (4 days) quit my morning cups (2) of
>coffee and am wondering if that's why I seem to
> be more even-tempered. Anyone w/ a caffeine
>taper story they'd lke to share?Maybe the negative effect is specifically due to the combination of caffeine and parnate. I don't know if this has been published anywhere but it figures they would have some interaction, and through personal experience I eventually figured out that it was a BAD combination.
I'm not a regular consumer of significant amounts of caffeine but I found it caused moderately unsettling effects while I was on Parnate (60mg/day) and (once I figured out this was happening) switched to decaffinated soda and kept the no-doze to a minimum.
S.D.
Posted by Seamus2 on June 15, 2000, at 21:31:45
In reply to concur: caffeine bad w/Parnate(Re: Amisulpride...) » Seamus2, posted by S.D. on June 12, 2000, at 4:34:49
>I eventually figured out that it was a BAD >combination.
Thanks for the feedback. I have a cup every other day now, and the withdrawal headaches are almost gone.
I really like not being so tense, and my frustration tolerance is almost normal now.
Seamus
Posted by iris2 on October 1, 2004, at 17:15:54
In reply to Re: Amisulpride, Andrew and all, posted by Ant-Rock on June 6, 2000, at 10:47:10
> > > Andrew:
> > >
> > > Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
> > >
> > Peter,
> >
> > Can amisulpride be combined with an MAOI? That is an important question. I think I can get an answer but give me some time. Keep checking back.
> >
> > AndrewB
> Hello everyone,
> I am currently taking 40mg Parnate, 25mg Amisulpride, and between 20-30mg Ritalin/day. I just added the amisulpride to the mix yesterday in hopes of giving me back some sex drive. My first trial of amisulpride @50mg and eventually 100mg didn't have any effect, but this was done without the Parnate. If there are any surprises(good or bad)with this combo I will let you know.
>
> Best wishes to all,
> Anthony
>
>Anthony,
I know this is a very old thread but perhaps I will get a response. I started taking 50mg AMisulpride a couple of months ago. THe only med that ever really helped me was Parnate but after many years it pooped out. I also take ritalin. So I was wondering how this mix was for you and if you thought that if I combined the Parnate with Amisulpride if it might work for me again?
irene
Posted by michael on October 1, 2004, at 21:16:10
In reply to Re: Amisulpride, Andrew and all » Ant-Rock, posted by iris2 on October 1, 2004, at 17:15:54
> > > > Andrew:
> > > >
> > > > Thanks for the information and advice. I have never heard of amisulpride being used with a MAOI but admittedly I've never done any research in the area. Has any research been done that demonstrates the safety and effectiveness of doing this? I'm going to check Medline and see what I come up with. I'm curious to see how Seamus does with it. Anyway thanks again.
> > > >
> > > Peter,
> > >
> > > Can amisulpride be combined with an MAOI? That is an important question. I think I can get an answer but give me some time. Keep checking back.
> > >
> > > AndrewB
> > Hello everyone,
> > I am currently taking 40mg Parnate, 25mg Amisulpride, and between 20-30mg Ritalin/day. I just added the amisulpride to the mix yesterday in hopes of giving me back some sex drive. My first trial of amisulpride @50mg and eventually 100mg didn't have any effect, but this was done without the Parnate. If there are any surprises(good or bad)with this combo I will let you know.
> >
> > Best wishes to all,
> > Anthony
> >
> >
>
> Anthony,
>
> I know this is a very old thread but perhaps I will get a response. I started taking 50mg AMisulpride a couple of months ago. THe only med that ever really helped me was Parnate but after many years it pooped out. I also take ritalin. So I was wondering how this mix was for you and if you thought that if I combined the Parnate with Amisulpride if it might work for me again?
>
> ireneHi Irene,
I had a question that I'd like to ask you off of PB... if you feel comfortable, could you drop me a line at [email protected] ? And we can continue off of the board?
If you're not comfortable with that, I understand, but I hope you'll drop me a quick line.
I'm kind of an "old-timer" in that I posted a lot back when this thread was current... and just check in occasionally these days.
Thanks.
michael
This is the end of the thread.
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